FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891648077> ?p ?o ?g. }

• W2891648077 abstract "4028 Background: The benefits and hazards of laparoscopic sentinel node oriented stomach-preserving surgery, compared to those of laparoscopic standard gastrectomy with lymph node dissection in early gastric cancer (EGC), are unknown. The SENORITA trial investigated the clinical impact of laparoscopic sentinel node oriented stomach-preserving surgery in EGC. Methods: Other than those with absolute indication for endoscopic resection, eligible patients had EGC confined to the mucosa and submucosa, with diameter ≤ 3cm, regardless of histology on preoperative evaluation. Patients were randomized for laparoscopic standard gastrectomy or laparoscopic stomach-preserving surgery. Patients were stratified based on depth (mucosa vs. submucosa) and size (≤ 2cm vs. 2 < ≤ 3cm) of the EGC and by participating institution. The primary endpoint was 3-year disease-free survival (3yDFS). The expected 3yDFS was 97% and non-inferior margin was 5%. 580 patients and 24 events were needed to show non-inferiority with 80% power. One interim analysis was planned after 12 events (50%) occurred. Using the O’Brien-Fleming error spending function, the two-sided nominal significance level for the interim analysis would be 0.0054. Results: From March 2013 to May 2016 462 patients were randomized; analysis was performed in 421 after a dropout of 41 patients. Laparoscopic stomach-preserving surgery was possible in 75.6% by study protocol. Interim analysis was conducted based on 12 events (median follow-up: 15.89 months). The 3yDFS in the laparoscopic standard gastrectomy arm was 96%; the 3yDFS in the laparoscopic stomach-preserving surgery arm was 93%, (99.46% CI: -3.18%, 9.18%). The postoperative complication rates were 15.0% and 12.9%, respectively (p = 0.542). Conclusions: In this interim analysis, laparoscopic sentinel node oriented stomach-preserving surgery did not show non-inferiority for 3yDFS. The follow-up time was not mature enough to evaluate non-inferiority. Further follow-up will elucidate the role of laparoscopic sentinel node oriented stomach-preserving surgery. Clinical trial information: NCT01804998." @default.
• W2891648077 created "2018-09-27" @default.
• W2891648077 creator A5000216660 @default.
• W2891648077 creator A5000217772 @default.
• W2891648077 creator A5000419851 @default.
• W2891648077 creator A5017735770 @default.
• W2891648077 creator A5018242338 @default.
• W2891648077 creator A5018729289 @default.
• W2891648077 creator A5021938664 @default.
• W2891648077 creator A5024761792 @default.
• W2891648077 creator A5024768100 @default.
• W2891648077 creator A5061052298 @default.
• W2891648077 creator A5066449485 @default.
• W2891648077 creator A5068541253 @default.
• W2891648077 creator A5072048377 @default.
• W2891648077 creator A5076132049 @default.
• W2891648077 creator A5079140720 @default.
• W2891648077 date "2017-05-20" @default.
• W2891648077 modified "2023-10-18" @default.
• W2891648077 title "Results of interim analysis of the multicenter randomized phase III SENORITA trial of laparoscopic sentinel node oriented, stomach-preserving surgery versus laparoscopic standard gastrectomy with lymph node dissection in early gastric cancer." @default.
• W2891648077 doi "https://doi.org/10.1200/jco.2017.35.15_suppl.4028" @default.
• W2891648077 hasPublicationYear "2017" @default.
• W2891648077 type Work @default.
• W2891648077 sameAs 2891648077 @default.
• W2891648077 citedByCount "4" @default.
• W2891648077 countsByYear W28916480772018 @default.
• W2891648077 countsByYear W28916480772019 @default.
• W2891648077 countsByYear W28916480772020 @default.
• W2891648077 countsByYear W28916480772021 @default.
• W2891648077 crossrefType "journal-article" @default.
• W2891648077 hasAuthorship W2891648077A5000216660 @default.
• W2891648077 hasAuthorship W2891648077A5000217772 @default.
• W2891648077 hasAuthorship W2891648077A5000419851 @default.
• W2891648077 hasAuthorship W2891648077A5017735770 @default.
• W2891648077 hasAuthorship W2891648077A5018242338 @default.
• W2891648077 hasAuthorship W2891648077A5018729289 @default.
• W2891648077 hasAuthorship W2891648077A5021938664 @default.
• W2891648077 hasAuthorship W2891648077A5024761792 @default.
• W2891648077 hasAuthorship W2891648077A5024768100 @default.
• W2891648077 hasAuthorship W2891648077A5061052298 @default.
• W2891648077 hasAuthorship W2891648077A5066449485 @default.
• W2891648077 hasAuthorship W2891648077A5068541253 @default.
• W2891648077 hasAuthorship W2891648077A5072048377 @default.
• W2891648077 hasAuthorship W2891648077A5076132049 @default.
• W2891648077 hasAuthorship W2891648077A5079140720 @default.
• W2891648077 hasConcept C121608353 @default.
• W2891648077 hasConcept C126322002 @default.
• W2891648077 hasConcept C141071460 @default.
• W2891648077 hasConcept C168563851 @default.
• W2891648077 hasConcept C179671157 @default.
• W2891648077 hasConcept C2775862295 @default.
• W2891648077 hasConcept C2776111594 @default.
• W2891648077 hasConcept C2779422922 @default.
• W2891648077 hasConcept C2779454504 @default.
• W2891648077 hasConcept C2780047204 @default.
• W2891648077 hasConcept C2780470880 @default.
• W2891648077 hasConcept C2780849966 @default.
• W2891648077 hasConcept C530470458 @default.
• W2891648077 hasConcept C61434518 @default.
• W2891648077 hasConcept C61943457 @default.
• W2891648077 hasConcept C71924100 @default.
• W2891648077 hasConceptScore W2891648077C121608353 @default.
• W2891648077 hasConceptScore W2891648077C126322002 @default.
• W2891648077 hasConceptScore W2891648077C141071460 @default.
• W2891648077 hasConceptScore W2891648077C168563851 @default.
• W2891648077 hasConceptScore W2891648077C179671157 @default.
• W2891648077 hasConceptScore W2891648077C2775862295 @default.
• W2891648077 hasConceptScore W2891648077C2776111594 @default.
• W2891648077 hasConceptScore W2891648077C2779422922 @default.
• W2891648077 hasConceptScore W2891648077C2779454504 @default.
• W2891648077 hasConceptScore W2891648077C2780047204 @default.
• W2891648077 hasConceptScore W2891648077C2780470880 @default.
• W2891648077 hasConceptScore W2891648077C2780849966 @default.
• W2891648077 hasConceptScore W2891648077C530470458 @default.
• W2891648077 hasConceptScore W2891648077C61434518 @default.
• W2891648077 hasConceptScore W2891648077C61943457 @default.
• W2891648077 hasConceptScore W2891648077C71924100 @default.
• W2891648077 hasLocation W28916480771 @default.
• W2891648077 hasOpenAccess W2891648077 @default.
• W2891648077 hasPrimaryLocation W28916480771 @default.
• W2891648077 isParatext "false" @default.
• W2891648077 isRetracted "false" @default.
• W2891648077 magId "2891648077" @default.
• W2891648077 workType "article" @default.