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- W2891648272 abstract "Acute liver failure (ALF) is a life-threatening disorder of liver function. Kynurenic acid (KYNA), a tryptophan metabolite formed along the kynurenine metabolic pathway, possesses anti-inflammatory and antioxidant properties. Its presence in food and its potential role in the digestive system was recently reported. The aim of this study was to define the effect of KYNA on liver failure. The Wistar rat model of thioacetamide-induced liver injury was used. Morphological and biochemical analyses as well as the measurement of KYNA content in liver and hepatoprotective herbal remedies were conducted. The significant attenuation of morphological disturbances and aspartate and alanine transaminase activities, decrease of myeloperoxidase and tumor necrosis factor- α , and elevation of interleukin-10 levels indicating the protective effect of KYNA in thioacetamide (TAA) - induced liver injury were discovered. In conclusion, the hepatoprotective role of KYNA in an animal model of liver failure was documented and the use of KYNA in the treatment of ALF was suggested." @default.
- W2891648272 created "2018-09-27" @default.
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- W2891648272 date "2018-09-20" @default.
- W2891648272 modified "2023-10-06" @default.
- W2891648272 title "Kynurenic Acid Protects against Thioacetamide-Induced Liver Injury in Rats" @default.
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- W2891648272 doi "https://doi.org/10.1155/2018/1270483" @default.
- W2891648272 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6171262" @default.
- W2891648272 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30327755" @default.
- W2891648272 hasPublicationYear "2018" @default.
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