FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891649293> ?p ?o ?g. }

• W2891649293 endingPage "332" @default.
• W2891649293 startingPage "323" @default.
• W2891649293 abstract "Abstract Radiolabeling of nanobodies with radiometals by chelation has the advantage of being simple, fast and easy to implement in clinical routine. In this study, we validated 68 Ga/ 111 In-labeled anti-VCAM-1 nanobodies as potential radiometal-based tracers for molecular imaging of atherosclerosis. Both showed specific targeting of atherosclerotic lesions in ApoE −/− mice. Nevertheless, uptake in lesions and constitutively VCAM-1 expressing organs was lower than previously reported for the 99m Tc-labeled analog. We further investigated the impact of different radiolabeling strategies on the in vivo biodistribution of nanobody-based tracers. Comparison of the pharmacokinetics between 68 Ga-, 18 F-, 111 In- and 99m Tc-labeled anti-VCAM-1 nanobodies showed highest specific uptake for 99m Tc-nanobody at all time-points, followed by the 68 Ga-, 111 In- and 18 F-labeled tracer. No correlation was found with the estimated number of radioisotopes per nanobody, and mimicking specific activity of other radiolabeling methods did not result in an analogous biodistribution. We also demonstrated specificity of the tracer using mice with a VCAM-1 knocked-down phenotype, while showing for the first time the in vivo visualization of a protein knock-down using intrabodies. Conclusively, the chosen radiochemistry does have an important impact on the biodistribution of nanobodies, in particular on the specific targeting, but differences are not purely due to the tracer’s specific activity." @default.
• W2891649293 created "2018-09-27" @default.
• W2891649293 creator A5002859621 @default.
• W2891649293 creator A5013509696 @default.
• W2891649293 creator A5023832801 @default.
• W2891649293 creator A5033536985 @default.
• W2891649293 creator A5038774090 @default.
• W2891649293 creator A5043280562 @default.
• W2891649293 creator A5054733696 @default.
• W2891649293 creator A5055775770 @default.
• W2891649293 creator A5057600219 @default.
• W2891649293 creator A5062972228 @default.
• W2891649293 creator A5067597833 @default.
• W2891649293 creator A5076475427 @default.
• W2891649293 creator A5076659429 @default.
• W2891649293 creator A5086513966 @default.
• W2891649293 creator A5086606052 @default.
• W2891649293 date "2018-09-21" @default.
• W2891649293 modified "2023-09-26" @default.
• W2891649293 title "Radiometal-labeled anti-VCAM-1 nanobodies as molecular tracers for atherosclerosis – impact of radiochemistry on pharmacokinetics" @default.
• W2891649293 cites W1520088546 @default.
• W2891649293 cites W1966335626 @default.
• W2891649293 cites W1970639304 @default.
• W2891649293 cites W2000278109 @default.
• W2891649293 cites W2001002356 @default.
• W2891649293 cites W2016016353 @default.
• W2891649293 cites W2056804961 @default.
• W2891649293 cites W2059650522 @default.
• W2891649293 cites W2067574572 @default.
• W2891649293 cites W2083416749 @default.
• W2891649293 cites W2098210920 @default.
• W2891649293 cites W2098231819 @default.
• W2891649293 cites W2107937036 @default.
• W2891649293 cites W2134212200 @default.
• W2891649293 cites W2145704311 @default.
• W2891649293 cites W2147077679 @default.
• W2891649293 cites W2158621028 @default.
• W2891649293 cites W2180627929 @default.
• W2891649293 cites W2226721696 @default.
• W2891649293 cites W2239740340 @default.
• W2891649293 cites W2253004405 @default.
• W2891649293 cites W2323389052 @default.
• W2891649293 cites W2325393979 @default.
• W2891649293 cites W2346602773 @default.
• W2891649293 cites W2346679845 @default.
• W2891649293 cites W2409577528 @default.
• W2891649293 cites W2555890824 @default.
• W2891649293 cites W2591767961 @default.
• W2891649293 cites W2593112982 @default.
• W2891649293 cites W2726555694 @default.
• W2891649293 cites W2734584386 @default.
• W2891649293 cites W2740293623 @default.
• W2891649293 cites W2752741458 @default.
• W2891649293 cites W2765676383 @default.
• W2891649293 cites W2766761160 @default.
• W2891649293 cites W2768168176 @default.
• W2891649293 cites W2791476909 @default.
• W2891649293 cites W2792254882 @default.
• W2891649293 cites W4240900378 @default.
• W2891649293 doi "https://doi.org/10.1515/hsz-2018-0330" @default.
• W2891649293 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30240352" @default.
• W2891649293 hasPublicationYear "2018" @default.
• W2891649293 type Work @default.
• W2891649293 sameAs 2891649293 @default.
• W2891649293 citedByCount "19" @default.
• W2891649293 countsByYear W28916492932019 @default.
• W2891649293 countsByYear W28916492932020 @default.
• W2891649293 countsByYear W28916492932021 @default.
• W2891649293 countsByYear W28916492932022 @default.
• W2891649293 countsByYear W28916492932023 @default.
• W2891649293 crossrefType "journal-article" @default.
• W2891649293 hasAuthorship W2891649293A5002859621 @default.
• W2891649293 hasAuthorship W2891649293A5013509696 @default.
• W2891649293 hasAuthorship W2891649293A5023832801 @default.
• W2891649293 hasAuthorship W2891649293A5033536985 @default.
• W2891649293 hasAuthorship W2891649293A5038774090 @default.
• W2891649293 hasAuthorship W2891649293A5043280562 @default.
• W2891649293 hasAuthorship W2891649293A5054733696 @default.
• W2891649293 hasAuthorship W2891649293A5055775770 @default.
• W2891649293 hasAuthorship W2891649293A5057600219 @default.
• W2891649293 hasAuthorship W2891649293A5062972228 @default.
• W2891649293 hasAuthorship W2891649293A5067597833 @default.
• W2891649293 hasAuthorship W2891649293A5076475427 @default.
• W2891649293 hasAuthorship W2891649293A5076659429 @default.
• W2891649293 hasAuthorship W2891649293A5086513966 @default.
• W2891649293 hasAuthorship W2891649293A5086606052 @default.
• W2891649293 hasConcept C112705442 @default.
• W2891649293 hasConcept C121332964 @default.
• W2891649293 hasConcept C1491633281 @default.
• W2891649293 hasConcept C150903083 @default.
• W2891649293 hasConcept C177322064 @default.
• W2891649293 hasConcept C185544564 @default.
• W2891649293 hasConcept C185592680 @default.
• W2891649293 hasConcept C202751555 @default.
• W2891649293 hasConcept C207001950 @default.
• W2891649293 hasConcept C2776985958 @default.
• W2891649293 hasConcept C2777807558 @default.
• W2891649293 hasConcept C2778863792 @default.

• next