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- W2891651490 abstract "Metastases are the major cause of cancer patients' mortality and can occur years and even decades following apparently successful treatment of the primary tumor. Early dissemination of cancer cells, followed by a protracted period of dormancy at distant sites, has been recently recognized as the clinical explanation for this very-long latency. The mechanisms that govern tumor dormancy at distant sites and their reactivation to proliferating metastases are just beginning to be unraveled. Tumor cells, that survive the immune surveillance and hemodynamic forces along their journey in the circulation and successfully colonize and adopt to the new and hostile microenvironment and survive in a quiescent dormant state for years before emerging to proliferative state, must display high plasticity. Here we will discuss whether the plasticity of dormant tumor cells is required for their long-term survival and outgrowth. Specifically, we will focus on whether epithelial mesenchymal transition and acquisition of stem-like properties can dictate their quiescent and or their proliferative fate. Deeper understanding of these intertwining processes may facilitate in the future the development of novel therapies." @default.
- W2891651490 created "2018-09-27" @default.
- W2891651490 creator A5001532850 @default.
- W2891651490 creator A5017021161 @default.
- W2891651490 date "2018-09-12" @default.
- W2891651490 modified "2023-10-15" @default.
- W2891651490 title "EMT and Stemness in Tumor Dormancy and Outgrowth: Are They Intertwined Processes?" @default.
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- W2891651490 doi "https://doi.org/10.3389/fonc.2018.00381" @default.
- W2891651490 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6145010" @default.
- W2891651490 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30258818" @default.
- W2891651490 hasPublicationYear "2018" @default.
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