FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891652118> ?p ?o ?g. }

• W2891652118 abstract "Vancomycin-resistant Enterococcus faecium (VREfm) has emerged as a nosocomial pathogen worldwide. The dissemination of VREfm is due to both clonal spread and spread of mobile genetic elements (MGEs) such as transposons. We aimed to combine vanB-carrying transposon data with core-genome MLST (cgMLST) typing and epidemiological data to understand the pathways of transmission in nosocomial outbreaks. Retrospectively, 36 VREfm isolates obtained from 34 patients from seven VREfm outbreak investigations in 2014 were analysed. Isolates were sequenced on a MiSeq and a MinION instrument. De novo assembly was performed in CLC Genomics Workbench and the hybrid assemblies were obtained through Unicycler v0.4.1. Ridom SeqSphere+ was used to extract MLST and cgMLST data. Detailed analysis of each transposon and their integration points was performed using the Artemis Comparison Tool (ACT) and multiple blast analyses. Four different vanB transposons were found among the isolates. cgMLST divided ST80 isolates into three cluster types (CTs); CT16, CT104 and CT106. ST117 isolates were divided into CT24, CT103 and CT105. Within VREfm isolates belonging to CT103, two different vanB transposons were found. In contrast, VREfm isolates belonging to CT104 and CT106 harboured an identical vanB transposon. cgMLST provides a high discriminatory power for the epidemiological analysis of VREfm. However, additional transposon analysis is needed to detect horizontal gene transfer. Combining these two methods allows investigation of both clonal spread as well as the spread of MGEs. This leads to new insights and thereby better understanding of the complex transmission routes in VREfm outbreaks." @default.
• W2891652118 created "2018-09-27" @default.
• W2891652118 creator A5002027586 @default.
• W2891652118 creator A5016594007 @default.
• W2891652118 creator A5026819464 @default.
• W2891652118 creator A5028348105 @default.
• W2891652118 creator A5033444811 @default.
• W2891652118 creator A5052955378 @default.
• W2891652118 creator A5075796846 @default.
• W2891652118 creator A5081489723 @default.
• W2891652118 creator A5083910434 @default.
• W2891652118 date "2018-09-14" @default.
• W2891652118 modified "2023-09-27" @default.
• W2891652118 title "Elucidating vancomycin-resistant Enterococcus faecium outbreaks: the role of clonal spread and movement of mobile genetic elements" @default.
• W2891652118 cites W1254889717 @default.
• W2891652118 cites W1977394427 @default.
• W2891652118 cites W1990152860 @default.
• W2891652118 cites W2008775770 @default.
• W2891652118 cites W2016092245 @default.
• W2891652118 cites W2034447035 @default.
• W2891652118 cites W2055329336 @default.
• W2891652118 cites W2056898357 @default.
• W2891652118 cites W2078424316 @default.
• W2891652118 cites W2086731525 @default.
• W2891652118 cites W2104657177 @default.
• W2891652118 cites W2111502970 @default.
• W2891652118 cites W2113960960 @default.
• W2891652118 cites W2114374509 @default.
• W2891652118 cites W2117737102 @default.
• W2891652118 cites W2141040548 @default.
• W2891652118 cites W2141503271 @default.
• W2891652118 cites W2145898006 @default.
• W2891652118 cites W2148206504 @default.
• W2891652118 cites W2153325555 @default.
• W2891652118 cites W2155867629 @default.
• W2891652118 cites W2160089263 @default.
• W2891652118 cites W2169297879 @default.
• W2891652118 cites W2170488656 @default.
• W2891652118 cites W2238205617 @default.
• W2891652118 cites W2293013056 @default.
• W2891652118 cites W2325121750 @default.
• W2891652118 cites W2343763025 @default.
• W2891652118 cites W2516462310 @default.
• W2891652118 cites W2516641646 @default.
• W2891652118 cites W2516671866 @default.
• W2891652118 cites W2519272862 @default.
• W2891652118 cites W2523707616 @default.
• W2891652118 cites W2561512876 @default.
• W2891652118 cites W2590678387 @default.
• W2891652118 cites W2602853700 @default.
• W2891652118 cites W2625741716 @default.
• W2891652118 cites W2738575597 @default.
• W2891652118 cites W2753382261 @default.
• W2891652118 cites W2766658767 @default.
• W2891652118 cites W2790297307 @default.
• W2891652118 cites W2952167528 @default.
• W2891652118 doi "https://doi.org/10.1093/jac/dky349" @default.
• W2891652118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30219855" @default.
• W2891652118 hasPublicationYear "2018" @default.
• W2891652118 type Work @default.
• W2891652118 sameAs 2891652118 @default.
• W2891652118 citedByCount "13" @default.
• W2891652118 countsByYear W28916521182019 @default.
• W2891652118 countsByYear W28916521182020 @default.
• W2891652118 countsByYear W28916521182021 @default.
• W2891652118 countsByYear W28916521182023 @default.
• W2891652118 crossrefType "journal-article" @default.
• W2891652118 hasAuthorship W2891652118A5002027586 @default.
• W2891652118 hasAuthorship W2891652118A5016594007 @default.
• W2891652118 hasAuthorship W2891652118A5026819464 @default.
• W2891652118 hasAuthorship W2891652118A5028348105 @default.
• W2891652118 hasAuthorship W2891652118A5033444811 @default.
• W2891652118 hasAuthorship W2891652118A5052955378 @default.
• W2891652118 hasAuthorship W2891652118A5075796846 @default.
• W2891652118 hasAuthorship W2891652118A5081489723 @default.
• W2891652118 hasAuthorship W2891652118A5083910434 @default.
• W2891652118 hasBestOaLocation W28916521181 @default.
• W2891652118 hasConcept C104317684 @default.
• W2891652118 hasConcept C116675565 @default.
• W2891652118 hasConcept C132533263 @default.
• W2891652118 hasConcept C135763542 @default.
• W2891652118 hasConcept C141231307 @default.
• W2891652118 hasConcept C159047783 @default.
• W2891652118 hasConcept C2777677444 @default.
• W2891652118 hasConcept C28693550 @default.
• W2891652118 hasConcept C4918238 @default.
• W2891652118 hasConcept C501593827 @default.
• W2891652118 hasConcept C54355233 @default.
• W2891652118 hasConcept C77434933 @default.
• W2891652118 hasConcept C86803240 @default.
• W2891652118 hasConcept C89423630 @default.
• W2891652118 hasConceptScore W2891652118C104317684 @default.
• W2891652118 hasConceptScore W2891652118C116675565 @default.
• W2891652118 hasConceptScore W2891652118C132533263 @default.
• W2891652118 hasConceptScore W2891652118C135763542 @default.
• W2891652118 hasConceptScore W2891652118C141231307 @default.
• W2891652118 hasConceptScore W2891652118C159047783 @default.
• W2891652118 hasConceptScore W2891652118C2777677444 @default.
• W2891652118 hasConceptScore W2891652118C28693550 @default.
• W2891652118 hasConceptScore W2891652118C4918238 @default.

• next