FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891652125> ?p ?o ?g. }

• W2891652125 endingPage "e13834" @default.
• W2891652125 startingPage "e13834" @default.
• W2891652125 abstract "Aging is associated with pulmonary vascular remodeling and reduced distensibility. We investigated the influence of aging on changes in cardiac output (Q), mean pulmonary artery pressure (mPAP), and lung diffusing capacity in response to alterations in thoracic blood volume. The role of pulmonary smooth muscle tone was also interrogated via pulmonary vasodilation. Nine younger (27 ± 4 years) and nine older (71 ± 4 years) healthy adults reached steady-state in a Supine (0°), Upright (+20°), or Head-down (-20°) position in order to alter thoracic blood volume. In each position, echocardiography was performed to calculate mPAP and Q, and lung diffusing capacity for carbon monoxide (DLCO) and nitric oxide (DLNO) was assessed. Next, 100 mg sildenafil was administered to reduce pulmonary smooth muscle tone, after which the protocol was repeated. mPAP (P ≤ 0.029) and Q (P ≤ 0.032) were lower in the Upright versus Supine and Head-down positions, and mPAP was reduced following sildenafil administration (P = 0.019), in older adults only. SV was lower in the Upright versus Supine and Head-down positions in both younger (P ≤ 0.008) and older (P ≤ 0.003) adults. DLCO and DLNO were not greatly altered by position changes or sildenafil administration. However, the DLNO/DLCO ratio was lower in the Supine and/or Head-down positions (P ≤ 0.05), but higher following sildenafil administration (P ≤ 0.007), in both younger and older adults. In conclusion, older adults experience greater cardiopulmonary alterations following thoracic blood volume changes, and pulmonary smooth muscle tone plays a role in resting mPAP in older adults only. Furthermore, mPAP is an important determinant of pulmonary capillary blood volume distribution (DLNO/DLCO), regardless of age." @default.
• W2891652125 created "2018-09-27" @default.
• W2891652125 creator A5009510630 @default.
• W2891652125 creator A5017952950 @default.
• W2891652125 creator A5018968404 @default.
• W2891652125 creator A5019595381 @default.
• W2891652125 date "2018-09-01" @default.
• W2891652125 modified "2023-10-12" @default.
• W2891652125 title "Age-dependent effects of thoracic and capillary blood volume distribution on pulmonary artery pressure and lung diffusing capacity" @default.
• W2891652125 cites W1522752367 @default.
• W2891652125 cites W1540988288 @default.
• W2891652125 cites W163500459 @default.
• W2891652125 cites W1986064139 @default.
• W2891652125 cites W2000198726 @default.
• W2891652125 cites W2037336807 @default.
• W2891652125 cites W2037693298 @default.
• W2891652125 cites W2038542706 @default.
• W2891652125 cites W2040077761 @default.
• W2891652125 cites W2041017713 @default.
• W2891652125 cites W2051134201 @default.
• W2891652125 cites W2051173440 @default.
• W2891652125 cites W2051655002 @default.
• W2891652125 cites W2058593962 @default.
• W2891652125 cites W2083565359 @default.
• W2891652125 cites W2101667804 @default.
• W2891652125 cites W2108678383 @default.
• W2891652125 cites W2112789217 @default.
• W2891652125 cites W2113669722 @default.
• W2891652125 cites W2120303646 @default.
• W2891652125 cites W2122337883 @default.
• W2891652125 cites W2125078269 @default.
• W2891652125 cites W2128761283 @default.
• W2891652125 cites W2132394822 @default.
• W2891652125 cites W2133212072 @default.
• W2891652125 cites W2147446910 @default.
• W2891652125 cites W2158458235 @default.
• W2891652125 cites W2163296746 @default.
• W2891652125 cites W2171024790 @default.
• W2891652125 cites W2253339331 @default.
• W2891652125 cites W2270419734 @default.
• W2891652125 cites W2294466415 @default.
• W2891652125 cites W2405075670 @default.
• W2891652125 cites W2413616926 @default.
• W2891652125 cites W2419369008 @default.
• W2891652125 cites W2424508788 @default.
• W2891652125 cites W2467895234 @default.
• W2891652125 cites W2600101189 @default.
• W2891652125 cites W2792943581 @default.
• W2891652125 cites W2891652125 @default.
• W2891652125 doi "https://doi.org/10.14814/phy2.13834" @default.
• W2891652125 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6119697" @default.
• W2891652125 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30175463" @default.
• W2891652125 hasPublicationYear "2018" @default.
• W2891652125 type Work @default.
• W2891652125 sameAs 2891652125 @default.
• W2891652125 citedByCount "8" @default.
• W2891652125 countsByYear W28916521252020 @default.
• W2891652125 countsByYear W28916521252022 @default.
• W2891652125 countsByYear W28916521252023 @default.
• W2891652125 crossrefType "journal-article" @default.
• W2891652125 hasAuthorship W2891652125A5009510630 @default.
• W2891652125 hasAuthorship W2891652125A5017952950 @default.
• W2891652125 hasAuthorship W2891652125A5018968404 @default.
• W2891652125 hasAuthorship W2891652125A5019595381 @default.
• W2891652125 hasBestOaLocation W28916521251 @default.
• W2891652125 hasConcept C125567185 @default.
• W2891652125 hasConcept C126322002 @default.
• W2891652125 hasConcept C16020263 @default.
• W2891652125 hasConcept C164705383 @default.
• W2891652125 hasConcept C165637977 @default.
• W2891652125 hasConcept C27101514 @default.
• W2891652125 hasConcept C2776768464 @default.
• W2891652125 hasConcept C2777714996 @default.
• W2891652125 hasConcept C2780940725 @default.
• W2891652125 hasConcept C2909063161 @default.
• W2891652125 hasConcept C3018587741 @default.
• W2891652125 hasConcept C37557685 @default.
• W2891652125 hasConcept C42219234 @default.
• W2891652125 hasConcept C55520419 @default.
• W2891652125 hasConcept C71924100 @default.
• W2891652125 hasConceptScore W2891652125C125567185 @default.
• W2891652125 hasConceptScore W2891652125C126322002 @default.
• W2891652125 hasConceptScore W2891652125C16020263 @default.
• W2891652125 hasConceptScore W2891652125C164705383 @default.
• W2891652125 hasConceptScore W2891652125C165637977 @default.
• W2891652125 hasConceptScore W2891652125C27101514 @default.
• W2891652125 hasConceptScore W2891652125C2776768464 @default.
• W2891652125 hasConceptScore W2891652125C2777714996 @default.
• W2891652125 hasConceptScore W2891652125C2780940725 @default.
• W2891652125 hasConceptScore W2891652125C2909063161 @default.
• W2891652125 hasConceptScore W2891652125C3018587741 @default.
• W2891652125 hasConceptScore W2891652125C37557685 @default.
• W2891652125 hasConceptScore W2891652125C42219234 @default.
• W2891652125 hasConceptScore W2891652125C55520419 @default.
• W2891652125 hasConceptScore W2891652125C71924100 @default.
• W2891652125 hasFunder F4320306143 @default.
• W2891652125 hasFunder F4320332161 @default.
• W2891652125 hasFunder F4320337472 @default.

• next