FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891654423> ?p ?o ?g. }

• W2891654423 abstract "Abstract Background Chronic intestinal pseudo‐obstruction (CIPO) and enteric dysmotility (ED) are severe intestinal motility disorders usually associated with underlying neuromuscular abnormalities. Objective To evaluate the in vitro neuromuscular function of patients with severe intestinal motility disorders. Methods Full‐thickness intestinal biopsies (16 jejunum and 3 ileum) obtained from patients with CIPO (n = 10) and ED (n = 9) were studied using muscle bath and microelectrode techniques. Control samples (n = 6 ileum and n = 6 jejunum) were used to establish the range of normality. Key Results Fourteen parameters were defined to assess muscle contractility and nerve‐muscle interaction: five to evaluate smooth muscle and interstitial cells of Cajal (ICC) and nine to evaluate inhibitory neuromuscular transmission. For each sample, a parameter was scored 0 if the value was inside the normal range or a value of 1 if it was outside. Patients’ samples (CIPO/ED) had more abnormal parameters than controls ( P < 0.001 for both jejunum and ileum). Functional abnormalities were found to be heterogeneous. The most prevalent abnormality was a decreased purinergic neuromuscular transmission, which was detected in 43.8% of jejunal samples. Conclusions and Inferences Abnormalities of neuromuscular intestinal function are detected in vitro in severe intestinal dysmotility. However, consistent with the heterogeneity of the disease pathophysiology, functional impairment cannot be attributed to a single mechanism. Specifically, defects of purinergic neuromuscular transmission may have an important role in motility disorders of the gastrointestinal tract." @default.
• W2891654423 created "2018-09-27" @default.
• W2891654423 creator A5007119829 @default.
• W2891654423 creator A5018799854 @default.
• W2891654423 creator A5033362809 @default.
• W2891654423 creator A5036381515 @default.
• W2891654423 creator A5056579004 @default.
• W2891654423 creator A5082448644 @default.
• W2891654423 creator A5082521715 @default.
• W2891654423 creator A5085838719 @default.
• W2891654423 date "2018-09-03" @default.
• W2891654423 modified "2023-10-05" @default.
• W2891654423 title "Functional neuromuscular impairment in severe intestinal dysmotility" @default.
• W2891654423 cites W1483144158 @default.
• W2891654423 cites W1515733047 @default.
• W2891654423 cites W1530088271 @default.
• W2891654423 cites W1583009778 @default.
• W2891654423 cites W1777935804 @default.
• W2891654423 cites W1914897265 @default.
• W2891654423 cites W1969087066 @default.
• W2891654423 cites W1973270602 @default.
• W2891654423 cites W1974732699 @default.
• W2891654423 cites W1979412100 @default.
• W2891654423 cites W1999847499 @default.
• W2891654423 cites W2003020093 @default.
• W2891654423 cites W2005996120 @default.
• W2891654423 cites W2009402224 @default.
• W2891654423 cites W2046307158 @default.
• W2891654423 cites W2051649066 @default.
• W2891654423 cites W2064524187 @default.
• W2891654423 cites W2087048554 @default.
• W2891654423 cites W2099022492 @default.
• W2891654423 cites W2110367384 @default.
• W2891654423 cites W2117281710 @default.
• W2891654423 cites W2129655287 @default.
• W2891654423 cites W2131289313 @default.
• W2891654423 cites W2136628620 @default.
• W2891654423 cites W2149388915 @default.
• W2891654423 cites W2156998940 @default.
• W2891654423 cites W2165299563 @default.
• W2891654423 cites W2184697282 @default.
• W2891654423 cites W2284857870 @default.
• W2891654423 cites W2525468837 @default.
• W2891654423 cites W2758585860 @default.
• W2891654423 cites W4294183732 @default.
• W2891654423 cites W4300620835 @default.
• W2891654423 doi "https://doi.org/10.1111/nmo.13458" @default.
• W2891654423 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30178519" @default.
• W2891654423 hasPublicationYear "2018" @default.
• W2891654423 type Work @default.
• W2891654423 sameAs 2891654423 @default.
• W2891654423 citedByCount "5" @default.
• W2891654423 countsByYear W28916544232019 @default.
• W2891654423 countsByYear W28916544232020 @default.
• W2891654423 countsByYear W28916544232021 @default.
• W2891654423 countsByYear W28916544232023 @default.
• W2891654423 crossrefType "journal-article" @default.
• W2891654423 hasAuthorship W2891654423A5007119829 @default.
• W2891654423 hasAuthorship W2891654423A5018799854 @default.
• W2891654423 hasAuthorship W2891654423A5033362809 @default.
• W2891654423 hasAuthorship W2891654423A5036381515 @default.
• W2891654423 hasAuthorship W2891654423A5056579004 @default.
• W2891654423 hasAuthorship W2891654423A5082448644 @default.
• W2891654423 hasAuthorship W2891654423A5082521715 @default.
• W2891654423 hasAuthorship W2891654423A5085838719 @default.
• W2891654423 hasConcept C10162356 @default.
• W2891654423 hasConcept C126322002 @default.
• W2891654423 hasConcept C134018914 @default.
• W2891654423 hasConcept C201539569 @default.
• W2891654423 hasConcept C204232928 @default.
• W2891654423 hasConcept C2776356852 @default.
• W2891654423 hasConcept C2776366702 @default.
• W2891654423 hasConcept C2776809568 @default.
• W2891654423 hasConcept C2776907353 @default.
• W2891654423 hasConcept C2777226302 @default.
• W2891654423 hasConcept C2780512811 @default.
• W2891654423 hasConcept C3020341438 @default.
• W2891654423 hasConcept C35147842 @default.
• W2891654423 hasConcept C54355233 @default.
• W2891654423 hasConcept C58207958 @default.
• W2891654423 hasConcept C71924100 @default.
• W2891654423 hasConcept C86803240 @default.
• W2891654423 hasConcept C90924648 @default.
• W2891654423 hasConceptScore W2891654423C10162356 @default.
• W2891654423 hasConceptScore W2891654423C126322002 @default.
• W2891654423 hasConceptScore W2891654423C134018914 @default.
• W2891654423 hasConceptScore W2891654423C201539569 @default.
• W2891654423 hasConceptScore W2891654423C204232928 @default.
• W2891654423 hasConceptScore W2891654423C2776356852 @default.
• W2891654423 hasConceptScore W2891654423C2776366702 @default.
• W2891654423 hasConceptScore W2891654423C2776809568 @default.
• W2891654423 hasConceptScore W2891654423C2776907353 @default.
• W2891654423 hasConceptScore W2891654423C2777226302 @default.
• W2891654423 hasConceptScore W2891654423C2780512811 @default.
• W2891654423 hasConceptScore W2891654423C3020341438 @default.
• W2891654423 hasConceptScore W2891654423C35147842 @default.
• W2891654423 hasConceptScore W2891654423C54355233 @default.
• W2891654423 hasConceptScore W2891654423C58207958 @default.
• W2891654423 hasConceptScore W2891654423C71924100 @default.
• W2891654423 hasConceptScore W2891654423C86803240 @default.

• next