FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891654939> ?p ?o ?g. }

• W2891654939 endingPage "e0203460" @default.
• W2891654939 startingPage "e0203460" @default.
• W2891654939 abstract "Elevated levels of FGF23 in individuals with chronic kidney disease (CKD) are associated with adverse health outcomes, such as increased mortality, large vessel disease, and reduced white matter volume, cardiovascular and cerebrovascular events. Apart from the well-known link between cardiovascular (CV) risk factors, especially diabetes and hypertension, and cerebrovascular damage, elevated FGF23 is also postulated to be associated with cerebrovascular damage independently of CKD. Elevated FGF23 predisposes to vascular calcification and is associated with vascular stiffness and endothelial dysfunction in the general population with normal renal function. These factors may lead to microangiopathic changes in the brain, cumulative ischemia, and eventually to the loss of white matter fibers. The relationship between FGF23 and brain integrity in individuals without CKD has hitherto not been investigated. In this study, we aimed to determine the association between FGF23, and white matter integrity in a cohort of 50 participants with varying degrees of CV risk burden, using high resolution structural human brain connectomes constructed from MRI diffusion images. We observed that increased FGF23 was associated with axonal loss in the frontal lobe, leading to a fragmentation of white matter network organization. This study provides the first description of the relationship between elevated levels of FGF23, white matter integrity, and brain health. We suggest a synergistic interaction of CV risk factors and FGF23 as a potentially novel determinant of brain health." @default.
• W2891654939 created "2018-09-27" @default.
• W2891654939 creator A5008906136 @default.
• W2891654939 creator A5013427003 @default.
• W2891654939 creator A5020781568 @default.
• W2891654939 creator A5038861511 @default.
• W2891654939 creator A5051033644 @default.
• W2891654939 creator A5060161230 @default.
• W2891654939 creator A5087174224 @default.
• W2891654939 date "2018-09-07" @default.
• W2891654939 modified "2023-10-12" @default.
• W2891654939 title "Fibroblast growth factor23 is associated with axonal integrity and neural network architecture in the human frontal lobes" @default.
• W2891654939 cites W1026628557 @default.
• W2891654939 cites W1983485726 @default.
• W2891654939 cites W2000133863 @default.
• W2891654939 cites W2000445173 @default.
• W2891654939 cites W2015668150 @default.
• W2891654939 cites W2037498463 @default.
• W2891654939 cites W2082108703 @default.
• W2891654939 cites W2095293504 @default.
• W2891654939 cites W2125079553 @default.
• W2891654939 cites W2127309075 @default.
• W2891654939 cites W2143729965 @default.
• W2891654939 cites W2157448600 @default.
• W2891654939 cites W2167822639 @default.
• W2891654939 cites W2168322307 @default.
• W2891654939 cites W2285075937 @default.
• W2891654939 cites W2296207885 @default.
• W2891654939 cites W2475261460 @default.
• W2891654939 cites W2527550773 @default.
• W2891654939 cites W2792583460 @default.
• W2891654939 doi "https://doi.org/10.1371/journal.pone.0203460" @default.
• W2891654939 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6128563" @default.
• W2891654939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30192823" @default.
• W2891654939 hasPublicationYear "2018" @default.
• W2891654939 type Work @default.
• W2891654939 sameAs 2891654939 @default.
• W2891654939 citedByCount "10" @default.
• W2891654939 countsByYear W28916549392020 @default.
• W2891654939 countsByYear W28916549392021 @default.
• W2891654939 countsByYear W28916549392023 @default.
• W2891654939 crossrefType "journal-article" @default.
• W2891654939 hasAuthorship W2891654939A5008906136 @default.
• W2891654939 hasAuthorship W2891654939A5013427003 @default.
• W2891654939 hasAuthorship W2891654939A5020781568 @default.
• W2891654939 hasAuthorship W2891654939A5038861511 @default.
• W2891654939 hasAuthorship W2891654939A5051033644 @default.
• W2891654939 hasAuthorship W2891654939A5060161230 @default.
• W2891654939 hasAuthorship W2891654939A5087174224 @default.
• W2891654939 hasBestOaLocation W28916549391 @default.
• W2891654939 hasConcept C114276007 @default.
• W2891654939 hasConcept C118552586 @default.
• W2891654939 hasConcept C126322002 @default.
• W2891654939 hasConcept C126838900 @default.
• W2891654939 hasConcept C134018914 @default.
• W2891654939 hasConcept C142724271 @default.
• W2891654939 hasConcept C143409427 @default.
• W2891654939 hasConcept C164705383 @default.
• W2891654939 hasConcept C2777670902 @default.
• W2891654939 hasConcept C2778653478 @default.
• W2891654939 hasConcept C2781192897 @default.
• W2891654939 hasConcept C2781208988 @default.
• W2891654939 hasConcept C2908647359 @default.
• W2891654939 hasConcept C519063684 @default.
• W2891654939 hasConcept C555293320 @default.
• W2891654939 hasConcept C71924100 @default.
• W2891654939 hasConcept C99454951 @default.
• W2891654939 hasConceptScore W2891654939C114276007 @default.
• W2891654939 hasConceptScore W2891654939C118552586 @default.
• W2891654939 hasConceptScore W2891654939C126322002 @default.
• W2891654939 hasConceptScore W2891654939C126838900 @default.
• W2891654939 hasConceptScore W2891654939C134018914 @default.
• W2891654939 hasConceptScore W2891654939C142724271 @default.
• W2891654939 hasConceptScore W2891654939C143409427 @default.
• W2891654939 hasConceptScore W2891654939C164705383 @default.
• W2891654939 hasConceptScore W2891654939C2777670902 @default.
• W2891654939 hasConceptScore W2891654939C2778653478 @default.
• W2891654939 hasConceptScore W2891654939C2781192897 @default.
• W2891654939 hasConceptScore W2891654939C2781208988 @default.
• W2891654939 hasConceptScore W2891654939C2908647359 @default.
• W2891654939 hasConceptScore W2891654939C519063684 @default.
• W2891654939 hasConceptScore W2891654939C555293320 @default.
• W2891654939 hasConceptScore W2891654939C71924100 @default.
• W2891654939 hasConceptScore W2891654939C99454951 @default.
• W2891654939 hasFunder F4320306230 @default.
• W2891654939 hasIssue "9" @default.
• W2891654939 hasLocation W28916549391 @default.
• W2891654939 hasLocation W28916549392 @default.
• W2891654939 hasLocation W28916549393 @default.
• W2891654939 hasLocation W28916549394 @default.
• W2891654939 hasLocation W28916549395 @default.
• W2891654939 hasLocation W28916549396 @default.
• W2891654939 hasLocation W28916549397 @default.
• W2891654939 hasOpenAccess W2891654939 @default.
• W2891654939 hasPrimaryLocation W28916549391 @default.
• W2891654939 hasRelatedWork W1970951771 @default.
• W2891654939 hasRelatedWork W1978325888 @default.
• W2891654939 hasRelatedWork W1986444559 @default.

• next