Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891661090> ?p ?o ?g. }
- W2891661090 endingPage "1976" @default.
- W2891661090 startingPage "1963" @default.
- W2891661090 abstract "Ceramide synthases (CerS) synthesize chain length specific ceramides (Cer), which mediate cellular processes in a chain length-dependent manner. In experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), we observed that the genetic deletion of CerS2 suppresses EAE pathology by interaction with granulocyte-colony stimulating factor (G-CSF) signaling and CXC motif chemokine receptor 2 (CXCR2) expression, leading to impaired neutrophil migration. In the present study, we investigated the importance of Cers and their synthesizing/metabolizing enzymes in MS. For this purpose, a longitudinal study with 72 MS patients and 25 healthy volunteers was performed. Blood samples were collected from healthy controls and MS patients over 1- or 3-year periods, respectively. Immune cells were counted using flow cytometry, ceramide levels were determined using liquid chromatography-tandem mass spectrometry, and mRNA expression was analyzed using quantitative PCR. In white blood cells, C16-LacCer and C24-Cer were down-regulated in MS patients in comparison with healthy controls. In plasma, C16-Cer, C24:1-Cer, C16-GluCer, and C24:1-GluCer were up-regulated and C16-LacCer was down-regulated in MS patients in comparison with healthy controls. Blood samples from MS patients were characterized by an increased B-cell number. However, there was no correlation between B-cell number and Cer levels. mRNA expression of Cer metabolizing enzymes and G-CSF signaling enzymes was significantly increased in MS patients. Interestingly, G-CSF receptor (G-CSFR) and CXCR2 mRNA expression correlated with CerS2 and UDP-glucose Cer glucosyltransferase (UGCG) mRNA expression. In conclusion, our results indicate that Cer metabolism is linked to G-CSF signaling in MS." @default.
- W2891661090 created "2018-09-27" @default.
- W2891661090 creator A5001346000 @default.
- W2891661090 creator A5002588358 @default.
- W2891661090 creator A5017526919 @default.
- W2891661090 creator A5022659881 @default.
- W2891661090 creator A5027230471 @default.
- W2891661090 creator A5031935590 @default.
- W2891661090 creator A5035883898 @default.
- W2891661090 creator A5039928935 @default.
- W2891661090 creator A5070863764 @default.
- W2891661090 creator A5078612562 @default.
- W2891661090 creator A5089223522 @default.
- W2891661090 date "2018-09-14" @default.
- W2891661090 modified "2023-10-16" @default.
- W2891661090 title "The relevance of ceramides and their synthesizing enzymes for multiple sclerosis" @default.
- W2891661090 cites W1494035906 @default.
- W2891661090 cites W1828576284 @default.
- W2891661090 cites W1983522573 @default.
- W2891661090 cites W1989482880 @default.
- W2891661090 cites W1997333990 @default.
- W2891661090 cites W1997601709 @default.
- W2891661090 cites W2007652184 @default.
- W2891661090 cites W2009454655 @default.
- W2891661090 cites W2010883684 @default.
- W2891661090 cites W2019339732 @default.
- W2891661090 cites W2030311333 @default.
- W2891661090 cites W2032227357 @default.
- W2891661090 cites W2040550995 @default.
- W2891661090 cites W2059783305 @default.
- W2891661090 cites W2069382959 @default.
- W2891661090 cites W2087968417 @default.
- W2891661090 cites W2088941906 @default.
- W2891661090 cites W2092122072 @default.
- W2891661090 cites W2105490558 @default.
- W2891661090 cites W2112165124 @default.
- W2891661090 cites W2119764013 @default.
- W2891661090 cites W2121725913 @default.
- W2891661090 cites W2155366992 @default.
- W2891661090 cites W2169599832 @default.
- W2891661090 cites W2298753429 @default.
- W2891661090 cites W2378519629 @default.
- W2891661090 cites W2518704280 @default.
- W2891661090 cites W2538330619 @default.
- W2891661090 cites W2548228770 @default.
- W2891661090 cites W2610021535 @default.
- W2891661090 cites W2624260673 @default.
- W2891661090 cites W2777074421 @default.
- W2891661090 cites W2789390897 @default.
- W2891661090 cites W2790525888 @default.
- W2891661090 cites W2801069891 @default.
- W2891661090 cites W2801291179 @default.
- W2891661090 cites W4211254511 @default.
- W2891661090 cites W4292474425 @default.
- W2891661090 doi "https://doi.org/10.1042/cs20180506" @default.
- W2891661090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30219773" @default.
- W2891661090 hasPublicationYear "2018" @default.
- W2891661090 type Work @default.
- W2891661090 sameAs 2891661090 @default.
- W2891661090 citedByCount "32" @default.
- W2891661090 countsByYear W28916610902019 @default.
- W2891661090 countsByYear W28916610902020 @default.
- W2891661090 countsByYear W28916610902021 @default.
- W2891661090 countsByYear W28916610902022 @default.
- W2891661090 countsByYear W28916610902023 @default.
- W2891661090 crossrefType "journal-article" @default.
- W2891661090 hasAuthorship W2891661090A5001346000 @default.
- W2891661090 hasAuthorship W2891661090A5002588358 @default.
- W2891661090 hasAuthorship W2891661090A5017526919 @default.
- W2891661090 hasAuthorship W2891661090A5022659881 @default.
- W2891661090 hasAuthorship W2891661090A5027230471 @default.
- W2891661090 hasAuthorship W2891661090A5031935590 @default.
- W2891661090 hasAuthorship W2891661090A5035883898 @default.
- W2891661090 hasAuthorship W2891661090A5039928935 @default.
- W2891661090 hasAuthorship W2891661090A5070863764 @default.
- W2891661090 hasAuthorship W2891661090A5078612562 @default.
- W2891661090 hasAuthorship W2891661090A5089223522 @default.
- W2891661090 hasConcept C126322002 @default.
- W2891661090 hasConcept C12823836 @default.
- W2891661090 hasConcept C13373296 @default.
- W2891661090 hasConcept C134018914 @default.
- W2891661090 hasConcept C153911025 @default.
- W2891661090 hasConcept C170493617 @default.
- W2891661090 hasConcept C185592680 @default.
- W2891661090 hasConcept C190283241 @default.
- W2891661090 hasConcept C203014093 @default.
- W2891661090 hasConcept C2777851122 @default.
- W2891661090 hasConcept C2778488018 @default.
- W2891661090 hasConcept C2780640218 @default.
- W2891661090 hasConcept C553184892 @default.
- W2891661090 hasConcept C55493867 @default.
- W2891661090 hasConcept C71924100 @default.
- W2891661090 hasConcept C84913492 @default.
- W2891661090 hasConcept C86803240 @default.
- W2891661090 hasConcept C8891405 @default.
- W2891661090 hasConceptScore W2891661090C126322002 @default.
- W2891661090 hasConceptScore W2891661090C12823836 @default.
- W2891661090 hasConceptScore W2891661090C13373296 @default.