Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891663149> ?p ?o ?g. }
- W2891663149 endingPage "1065" @default.
- W2891663149 startingPage "1053" @default.
- W2891663149 abstract "The discovery of RNA interference (RNAi) earned the 2006 Nobel Prize in Physiology or Medicine for its biological significance and potential for developing novel therapeutics. The small interfering RNA (siRNA) is the most promising tool for translating RNAi to clinical use. Efforts are ongoing to improve siRNA delivery through developing novel biomaterials and delivery strategies. Given time, it appears that siRNA drugs will eventually become a reality.The currently used approaches for siRNA delivery are discussed with a focus on siRNA therapeutics currently in clinical testing. A comparison of advantageous aspects of currently available platforms and the possibility of further optimization for increased efficiency and safety are presented. Future directions in siRNA delivery are also highlighted.The recent success in the field of siRNA delivery is based mainly on developing new biomaterials with extraordinarily high activities. Notably, the introduction of ionizable lipids and novel targeting ligands represent two huge steps for realizing siRNA therapy. The currently available systems are largely directed to the liver and the new challenge is to extend their applicability for treating diseases of other organs. Active targeting to different organs is the most promising approach for developing new siRNA-based therapeutics." @default.
- W2891663149 created "2018-09-27" @default.
- W2891663149 creator A5004654599 @default.
- W2891663149 creator A5006918664 @default.
- W2891663149 creator A5045866529 @default.
- W2891663149 date "2018-09-25" @default.
- W2891663149 modified "2023-09-29" @default.
- W2891663149 title "Optimization of siRNA delivery to target sites: issues and future directions" @default.
- W2891663149 cites W1093133732 @default.
- W2891663149 cites W1504561806 @default.
- W2891663149 cites W1511669342 @default.
- W2891663149 cites W1611419331 @default.
- W2891663149 cites W1647075334 @default.
- W2891663149 cites W1675450733 @default.
- W2891663149 cites W1743672919 @default.
- W2891663149 cites W1963680025 @default.
- W2891663149 cites W1964543312 @default.
- W2891663149 cites W1967660067 @default.
- W2891663149 cites W1967765481 @default.
- W2891663149 cites W1971290197 @default.
- W2891663149 cites W1972243884 @default.
- W2891663149 cites W1974303227 @default.
- W2891663149 cites W1974752722 @default.
- W2891663149 cites W1975581901 @default.
- W2891663149 cites W1976463496 @default.
- W2891663149 cites W1981956388 @default.
- W2891663149 cites W1982902233 @default.
- W2891663149 cites W1983275470 @default.
- W2891663149 cites W1986157095 @default.
- W2891663149 cites W1988313934 @default.
- W2891663149 cites W1988771204 @default.
- W2891663149 cites W1993387264 @default.
- W2891663149 cites W1998908425 @default.
- W2891663149 cites W2000678720 @default.
- W2891663149 cites W2000959104 @default.
- W2891663149 cites W2002050544 @default.
- W2891663149 cites W2012931740 @default.
- W2891663149 cites W2019387053 @default.
- W2891663149 cites W2019631541 @default.
- W2891663149 cites W2026198085 @default.
- W2891663149 cites W2026889244 @default.
- W2891663149 cites W2028156849 @default.
- W2891663149 cites W2029827106 @default.
- W2891663149 cites W2030652381 @default.
- W2891663149 cites W2031630601 @default.
- W2891663149 cites W2033711847 @default.
- W2891663149 cites W2034139519 @default.
- W2891663149 cites W2035342960 @default.
- W2891663149 cites W2036928635 @default.
- W2891663149 cites W2040564031 @default.
- W2891663149 cites W2042546793 @default.
- W2891663149 cites W2043069157 @default.
- W2891663149 cites W2046962658 @default.
- W2891663149 cites W2048369172 @default.
- W2891663149 cites W2048809853 @default.
- W2891663149 cites W2049233124 @default.
- W2891663149 cites W2051091654 @default.
- W2891663149 cites W2053515735 @default.
- W2891663149 cites W2054745605 @default.
- W2891663149 cites W2055714377 @default.
- W2891663149 cites W2058841557 @default.
- W2891663149 cites W2060058804 @default.
- W2891663149 cites W2060170811 @default.
- W2891663149 cites W2060221489 @default.
- W2891663149 cites W2060956312 @default.
- W2891663149 cites W2064808830 @default.
- W2891663149 cites W2073244815 @default.
- W2891663149 cites W2078377919 @default.
- W2891663149 cites W2078890343 @default.
- W2891663149 cites W2079321730 @default.
- W2891663149 cites W2079445254 @default.
- W2891663149 cites W2081557929 @default.
- W2891663149 cites W2083249633 @default.
- W2891663149 cites W2083710155 @default.
- W2891663149 cites W2084671299 @default.
- W2891663149 cites W2086919915 @default.
- W2891663149 cites W2091878182 @default.
- W2891663149 cites W2091993321 @default.
- W2891663149 cites W2094503153 @default.
- W2891663149 cites W2095151181 @default.
- W2891663149 cites W2095317094 @default.
- W2891663149 cites W2097131232 @default.
- W2891663149 cites W2099753372 @default.
- W2891663149 cites W2100181290 @default.
- W2891663149 cites W2105364677 @default.
- W2891663149 cites W2106885643 @default.
- W2891663149 cites W2108882170 @default.
- W2891663149 cites W2116424844 @default.
- W2891663149 cites W2117698690 @default.
- W2891663149 cites W2120847624 @default.
- W2891663149 cites W2124018243 @default.
- W2891663149 cites W2126002712 @default.
- W2891663149 cites W2127409621 @default.
- W2891663149 cites W2127509551 @default.
- W2891663149 cites W2134254622 @default.
- W2891663149 cites W2135286723 @default.
- W2891663149 cites W2135314242 @default.
- W2891663149 cites W2138331126 @default.