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- W2891663770 abstract "Notch signalling regulates a plethora of developmental processes and is also essential for the maintenance of tissue homeostasis in adults. Therefore, fine‐tuning of Notch signalling strength needs to be tightly regulated. Of key importance for the regulation of Notch signalling are O‐fucose, O‐GlcNAc and O‐glucose glycans attached to the extracellular domain of Notch receptors. The EGF repeats of the Notch receptor extracellular domain harbour consensus sites for addition of the different types of O‐glycan to Ser or Thr, which takes place in the endoplasmic reticulum. Studies from Drosophila to mammals have demonstrated the multifaceted roles of O‐glycosylation in regulating Notch signalling. O‐glycosylation modulates different aspects of Notch signalling including recognition by Notch ligands, the strength of ligand binding, Notch receptor trafficking, stability and activation at the cell surface. Defects in O‐glycosylation of Notch receptors give rise to pathologies in humans. This Review summarizes the nature of the O‐glycans on Notch receptors and their differential effects on Notch signalling." @default.
- W2891663770 created "2018-09-27" @default.
- W2891663770 creator A5008850684 @default.
- W2891663770 creator A5085697781 @default.
- W2891663770 date "2018-11-28" @default.
- W2891663770 modified "2023-10-16" @default.
- W2891663770 title "Multiple roles for O‐glycans in Notch signalling" @default.
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