FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891664089> ?p ?o ?g. }

• W2891664089 abstract "Despite advances in diagnosing latent Mycobacterium tuberculosis infection (LTBI), we still lack a diagnostic test that differentiates LTBI from active tuberculosis (TB) or predicts the risk of progression to active disease. One reason for the absence of such a test may be the failure of current assays to capture the dynamic complexities of the immune responses associated with various stages of TB, since these assays measure only a single parameter (release of IFNγ) and rely on prolonged (overnight) T cell stimulation. We describe a novel, semi-automated RNA flow cytometry assay to determine whether immunological differences can be identified between LTBI and active TB. We analyzed antigen-induced expression of Th1 cytokine mRNA after short (2- and 6-hr) stimulation with antigen, in the context of memory T cell immunophenotyping. IFNG and TNFA mRNA induction was detectable in CD4+ T cells after only two hours of ex vivo stimulation. Moreover, IFNG- and TNFA-expressing CD4+ T cells (Th1 cells) were more frequent in active TB than in LTBI, a difference that is undetectable with conventional, protein-based cytokine assays. We also found that active TB was associated with higher ratios of effector memory to central memory Th1 cells than LTBI. This effector memory phenotype of active TB was associated with increased T cell differentiation, as defined by loss of the CD27 marker, but not with T cell exhaustion, as determined by PD-1 abundance. These results indicate that single-cell-based, mRNA measurements may help identify time-dependent, quantitative differences in T cell functional status between latent infection and active tuberculosis." @default.
• W2891664089 created "2018-09-27" @default.
• W2891664089 creator A5016820657 @default.
• W2891664089 creator A5019704297 @default.
• W2891664089 creator A5024623344 @default.
• W2891664089 creator A5030824397 @default.
• W2891664089 creator A5031322666 @default.
• W2891664089 creator A5040039042 @default.
• W2891664089 creator A5069419075 @default.
• W2891664089 creator A5076764205 @default.
• W2891664089 creator A5083062157 @default.
• W2891664089 creator A5086026022 @default.
• W2891664089 creator A5087865572 @default.
• W2891664089 date "2018-09-19" @default.
• W2891664089 modified "2023-10-14" @default.
• W2891664089 title "Active Tuberculosis Is Characterized by Highly Differentiated Effector Memory Th1 Cells" @default.
• W2891664089 cites W1574493485 @default.
• W2891664089 cites W1577972394 @default.
• W2891664089 cites W1721778868 @default.
• W2891664089 cites W1758071973 @default.
• W2891664089 cites W1818285885 @default.
• W2891664089 cites W1851889474 @default.
• W2891664089 cites W1928259156 @default.
• W2891664089 cites W1966646357 @default.
• W2891664089 cites W1969623044 @default.
• W2891664089 cites W1976123633 @default.
• W2891664089 cites W1979316802 @default.
• W2891664089 cites W1981480494 @default.
• W2891664089 cites W1986141714 @default.
• W2891664089 cites W2017173637 @default.
• W2891664089 cites W2027189611 @default.
• W2891664089 cites W2028462978 @default.
• W2891664089 cites W2031665177 @default.
• W2891664089 cites W2042903758 @default.
• W2891664089 cites W2042958357 @default.
• W2891664089 cites W2044061178 @default.
• W2891664089 cites W2045427095 @default.
• W2891664089 cites W2048019396 @default.
• W2891664089 cites W2056521763 @default.
• W2891664089 cites W2091480184 @default.
• W2891664089 cites W2095433947 @default.
• W2891664089 cites W2102099892 @default.
• W2891664089 cites W2102799596 @default.
• W2891664089 cites W2104486115 @default.
• W2891664089 cites W2113847305 @default.
• W2891664089 cites W2118527316 @default.
• W2891664089 cites W2123093300 @default.
• W2891664089 cites W2136209171 @default.
• W2891664089 cites W2138201323 @default.
• W2891664089 cites W2141090053 @default.
• W2891664089 cites W2153987199 @default.
• W2891664089 cites W2154501280 @default.
• W2891664089 cites W2158382118 @default.
• W2891664089 cites W2160129587 @default.
• W2891664089 cites W2160202077 @default.
• W2891664089 cites W2211897770 @default.
• W2891664089 cites W2436108958 @default.
• W2891664089 cites W2462273350 @default.
• W2891664089 cites W2468833422 @default.
• W2891664089 cites W2540385479 @default.
• W2891664089 cites W2578293828 @default.
• W2891664089 cites W2614154655 @default.
• W2891664089 cites W2620764135 @default.
• W2891664089 cites W2625798606 @default.
• W2891664089 cites W2744206105 @default.
• W2891664089 cites W2761586559 @default.
• W2891664089 cites W2762649195 @default.
• W2891664089 cites W2765354416 @default.
• W2891664089 cites W2918492503 @default.
• W2891664089 cites W4238473618 @default.
• W2891664089 doi "https://doi.org/10.3389/fimmu.2018.02127" @default.
• W2891664089 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6156157" @default.
• W2891664089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30283456" @default.
• W2891664089 hasPublicationYear "2018" @default.
• W2891664089 type Work @default.
• W2891664089 sameAs 2891664089 @default.
• W2891664089 citedByCount "23" @default.
• W2891664089 countsByYear W28916640892019 @default.
• W2891664089 countsByYear W28916640892020 @default.
• W2891664089 countsByYear W28916640892021 @default.
• W2891664089 countsByYear W28916640892022 @default.
• W2891664089 countsByYear W28916640892023 @default.
• W2891664089 crossrefType "journal-article" @default.
• W2891664089 hasAuthorship W2891664089A5016820657 @default.
• W2891664089 hasAuthorship W2891664089A5019704297 @default.
• W2891664089 hasAuthorship W2891664089A5024623344 @default.
• W2891664089 hasAuthorship W2891664089A5030824397 @default.
• W2891664089 hasAuthorship W2891664089A5031322666 @default.
• W2891664089 hasAuthorship W2891664089A5040039042 @default.
• W2891664089 hasAuthorship W2891664089A5069419075 @default.
• W2891664089 hasAuthorship W2891664089A5076764205 @default.
• W2891664089 hasAuthorship W2891664089A5083062157 @default.
• W2891664089 hasAuthorship W2891664089A5086026022 @default.
• W2891664089 hasAuthorship W2891664089A5087865572 @default.
• W2891664089 hasBestOaLocation W28916640891 @default.
• W2891664089 hasConcept C142724271 @default.
• W2891664089 hasConcept C147483822 @default.
• W2891664089 hasConcept C150903083 @default.
• W2891664089 hasConcept C151730666 @default.
• W2891664089 hasConcept C196166836 @default.

• next