FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891666803> ?p ?o ?g. }

• W2891666803 abstract "To compare efficacy and safety of tapentadol prolonged release (PR) vs oxycodone controlled release (CR) in younger patients (<65 years of age) and in elderly patients (≥65 and ≥75 years of age) in the treatment of moderate-to-severe chronic osteoarthritis (OA) knee pain.Data from two double-blind, randomized, placebo-, and oxycodone CR-controlled phase 3 trials were pooled and stratified by age. Primary efficacy end-points were change from baseline in average pain intensity at week 12 (US end-point) and over the entire maintenance period (non-US end-point).A total of 1357 patients <65 years, 653 patients ≥65 years, and 176 patients ≥75 years of age were assessed. The comparison between tapentadol PR and oxycodone CR showed numerically better pain relief under tapentadol PR for both primary end-points in all three age groups. More favorable improvements were also observed for patient global impression of change, the Short Form-36 physical component score, and EuroQoL-5Dimensions health status index. In the elderly, incidences of dizziness and somnolence were comparable between active treatments, but incidences of nausea, vomiting, and constipation were considerably lower under tapentadol PR. Treatment completion rates were lowest under oxycodone CR; > 50% of elderly oxycodone CR patients named side-effects as the main reason for discontinuation.Tapentadol PR was effective in the treatment of moderate-to-severe chronic OA pain in elderly and younger patients. Compared to oxycodone CR, the overall and the gastrointestinal tolerability profile in particular were better in all tapentadol PR groups, regardless of age." @default.
• W2891666803 created "2018-09-27" @default.
• W2891666803 creator A5011351278 @default.
• W2891666803 creator A5043813679 @default.
• W2891666803 creator A5059702360 @default.
• W2891666803 creator A5086306975 @default.
• W2891666803 date "2018-09-17" @default.
• W2891666803 modified "2023-09-27" @default.
• W2891666803 title "Efficacy and safety of tapentadol prolonged release formulation in the treatment of elderly patients with moderate-to-severe chronic osteoarthritis knee pain: a pooled analysis of two double-blind, randomized, placebo-, and active-controlled trials" @default.
• W2891666803 cites W1494229485 @default.
• W2891666803 cites W1562338169 @default.
• W2891666803 cites W1575211640 @default.
• W2891666803 cites W1857966818 @default.
• W2891666803 cites W1984271619 @default.
• W2891666803 cites W2003069609 @default.
• W2891666803 cites W2010818945 @default.
• W2891666803 cites W2032624822 @default.
• W2891666803 cites W2036491373 @default.
• W2891666803 cites W2054069591 @default.
• W2891666803 cites W2063137468 @default.
• W2891666803 cites W2071441738 @default.
• W2891666803 cites W2075558793 @default.
• W2891666803 cites W2083213461 @default.
• W2891666803 cites W2129650714 @default.
• W2891666803 cites W2135956897 @default.
• W2891666803 cites W2137971952 @default.
• W2891666803 cites W2161736885 @default.
• W2891666803 cites W2169426067 @default.
• W2891666803 cites W2341767059 @default.
• W2891666803 cites W2473786944 @default.
• W2891666803 cites W2567289819 @default.
• W2891666803 cites W2618485516 @default.
• W2891666803 cites W2620545124 @default.
• W2891666803 cites W2765096927 @default.
• W2891666803 cites W4245966879 @default.
• W2891666803 cites W4292806894 @default.
• W2891666803 doi "https://doi.org/10.1080/03007995.2018.1520085" @default.
• W2891666803 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30200781" @default.
• W2891666803 hasPublicationYear "2018" @default.
• W2891666803 type Work @default.
• W2891666803 sameAs 2891666803 @default.
• W2891666803 citedByCount "9" @default.
• W2891666803 countsByYear W28916668032018 @default.
• W2891666803 countsByYear W28916668032019 @default.
• W2891666803 countsByYear W28916668032020 @default.
• W2891666803 countsByYear W28916668032021 @default.
• W2891666803 countsByYear W28916668032022 @default.
• W2891666803 crossrefType "journal-article" @default.
• W2891666803 hasAuthorship W2891666803A5011351278 @default.
• W2891666803 hasAuthorship W2891666803A5043813679 @default.
• W2891666803 hasAuthorship W2891666803A5059702360 @default.
• W2891666803 hasAuthorship W2891666803A5086306975 @default.
• W2891666803 hasConcept C126322002 @default.
• W2891666803 hasConcept C142724271 @default.
• W2891666803 hasConcept C168563851 @default.
• W2891666803 hasConcept C170493617 @default.
• W2891666803 hasConcept C197934379 @default.
• W2891666803 hasConcept C203092338 @default.
• W2891666803 hasConcept C204787440 @default.
• W2891666803 hasConcept C27081682 @default.
• W2891666803 hasConcept C2776029756 @default.
• W2891666803 hasConcept C2776164576 @default.
• W2891666803 hasConcept C2778375690 @default.
• W2891666803 hasConcept C2778715236 @default.
• W2891666803 hasConcept C2780505013 @default.
• W2891666803 hasConcept C2780580376 @default.
• W2891666803 hasConcept C2781063702 @default.
• W2891666803 hasConcept C42219234 @default.
• W2891666803 hasConcept C71924100 @default.
• W2891666803 hasConceptScore W2891666803C126322002 @default.
• W2891666803 hasConceptScore W2891666803C142724271 @default.
• W2891666803 hasConceptScore W2891666803C168563851 @default.
• W2891666803 hasConceptScore W2891666803C170493617 @default.
• W2891666803 hasConceptScore W2891666803C197934379 @default.
• W2891666803 hasConceptScore W2891666803C203092338 @default.
• W2891666803 hasConceptScore W2891666803C204787440 @default.
• W2891666803 hasConceptScore W2891666803C27081682 @default.
• W2891666803 hasConceptScore W2891666803C2776029756 @default.
• W2891666803 hasConceptScore W2891666803C2776164576 @default.
• W2891666803 hasConceptScore W2891666803C2778375690 @default.
• W2891666803 hasConceptScore W2891666803C2778715236 @default.
• W2891666803 hasConceptScore W2891666803C2780505013 @default.
• W2891666803 hasConceptScore W2891666803C2780580376 @default.
• W2891666803 hasConceptScore W2891666803C2781063702 @default.
• W2891666803 hasConceptScore W2891666803C42219234 @default.
• W2891666803 hasConceptScore W2891666803C71924100 @default.
• W2891666803 hasLocation W28916668031 @default.
• W2891666803 hasLocation W28916668032 @default.
• W2891666803 hasOpenAccess W2891666803 @default.
• W2891666803 hasPrimaryLocation W28916668031 @default.
• W2891666803 hasRelatedWork W1562338169 @default.
• W2891666803 hasRelatedWork W1966031956 @default.
• W2891666803 hasRelatedWork W2029032162 @default.
• W2891666803 hasRelatedWork W2072869449 @default.
• W2891666803 hasRelatedWork W2341767059 @default.
• W2891666803 hasRelatedWork W3035431056 @default.
• W2891666803 hasRelatedWork W4255344021 @default.
• W2891666803 hasRelatedWork W4255832339 @default.
• W2891666803 hasRelatedWork W2340667129 @default.
• W2891666803 hasRelatedWork W2625609475 @default.

• next