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- W2891669318 abstract "The real-time search for native RNA structure is essential for the operation of regulatory RNAs. We previously reported that a fraction of the Azoarcus ribozyme achieves a compact structure in less than a millisecond. To scrutinize the forces that drive initial folding steps, we used time-resolved SAXS to compare the folding dynamics of this ribozyme in thermodynamically isostable concentrations of different counterions. The results show that the size of the fast-folding population increases with the number of available counterions and correlates with the flexibility of initial RNA structures. Within 1 ms of folding, Mg2+ exhibits a smaller preferential interaction coefficient per charge, ΔΓ+/ Z, than Na+ or [Co(NH3)6]3+. The lower ΔΓ+/ Z corresponds to a smaller yield of folded RNA, although Mg2+ stabilizes native RNA more efficiently than other ions at equilibrium. These results suggest that strong Mg2+-RNA interactions impede the search for globally native structure during early folding stages." @default.
- W2891669318 created "2018-09-27" @default.
- W2891669318 creator A5024679686 @default.
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- W2891669318 creator A5055168582 @default.
- W2891669318 creator A5078281937 @default.
- W2891669318 creator A5087892164 @default.
- W2891669318 date "2018-09-13" @default.
- W2891669318 modified "2023-10-03" @default.
- W2891669318 title "Effects of Preferential Counterion Interactions on the Specificity of RNA Folding" @default.
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- W2891669318 doi "https://doi.org/10.1021/acs.jpclett.8b02086" @default.
- W2891669318 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6351067" @default.
- W2891669318 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30211556" @default.
- W2891669318 hasPublicationYear "2018" @default.
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