FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891669949> ?p ?o ?g. }

• W2891669949 endingPage "960" @default.
• W2891669949 startingPage "953" @default.
• W2891669949 abstract "1. Leniolisib is a novel oral phosphatidylinositol-3-kinase (PI3K) delta inhibitor, currently in clinical development for the treatment of inflammatory and autoimmune diseases.2. We investigated the absorption, metabolism, and excretion of leniolisib in healthy subjects after a single oral 400 mg dose as part of a first-in-human clinical study. The parent drug and metabolites were quantified by 19F-NMR in plasma, urine and faeces after liquid chromatography separation, and structures were determined by liquid chromatography coupled to tandem mass spectrometry.3. Drug-related material was mainly excreted as oxidative metabolites in urine and faeces, providing evidence that elimination occurs mainly by metabolism. No metabolites were abundant in plasma relative to the parent drug. An average mass balance of 66% was obtained, demonstrating that relatively extensive elimination/excretion data can be obtained by 19F-NMR in a first in human clinical study without the use of a radiolabeled drug." @default.
• W2891669949 created "2018-09-27" @default.
• W2891669949 creator A5028579261 @default.
• W2891669949 creator A5057363726 @default.
• W2891669949 creator A5058612370 @default.
• W2891669949 creator A5065698906 @default.
• W2891669949 creator A5069713540 @default.
• W2891669949 date "2018-11-29" @default.
• W2891669949 modified "2023-10-10" @default.
• W2891669949 title "¹⁹F-NMR-based determination of the absorption, metabolism and excretion of the oral phosphatidylinositol-3-kinase (PI3K) delta inhibitor leniolisib (CDZ173) in healthy volunteers" @default.
• W2891669949 cites W1891390669 @default.
• W2891669949 cites W1976169212 @default.
• W2891669949 cites W1990938178 @default.
• W2891669949 cites W2005087793 @default.
• W2891669949 cites W2013688004 @default.
• W2891669949 cites W2015875316 @default.
• W2891669949 cites W2039054635 @default.
• W2891669949 cites W2087505156 @default.
• W2891669949 cites W2098176676 @default.
• W2891669949 cites W2133849435 @default.
• W2891669949 cites W2166512580 @default.
• W2891669949 cites W2318013894 @default.
• W2891669949 cites W2608523805 @default.
• W2891669949 cites W2619821219 @default.
• W2891669949 cites W2749370327 @default.
• W2891669949 cites W2761652334 @default.
• W2891669949 cites W2789021804 @default.
• W2891669949 cites W2799596524 @default.
• W2891669949 cites W2889287604 @default.
• W2891669949 doi "https://doi.org/10.1080/00498254.2018.1523488" @default.
• W2891669949 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30215545" @default.
• W2891669949 hasPublicationYear "2018" @default.
• W2891669949 type Work @default.
• W2891669949 sameAs 2891669949 @default.
• W2891669949 citedByCount "8" @default.
• W2891669949 countsByYear W28916699492019 @default.
• W2891669949 countsByYear W28916699492020 @default.
• W2891669949 countsByYear W28916699492022 @default.
• W2891669949 countsByYear W28916699492023 @default.
• W2891669949 crossrefType "journal-article" @default.
• W2891669949 hasAuthorship W2891669949A5028579261 @default.
• W2891669949 hasAuthorship W2891669949A5057363726 @default.
• W2891669949 hasAuthorship W2891669949A5058612370 @default.
• W2891669949 hasAuthorship W2891669949A5065698906 @default.
• W2891669949 hasAuthorship W2891669949A5069713540 @default.
• W2891669949 hasBestOaLocation W28916699492 @default.
• W2891669949 hasConcept C10146269 @default.
• W2891669949 hasConcept C112705442 @default.
• W2891669949 hasConcept C121332964 @default.
• W2891669949 hasConcept C125287762 @default.
• W2891669949 hasConcept C179998833 @default.
• W2891669949 hasConcept C184235292 @default.
• W2891669949 hasConcept C185592680 @default.
• W2891669949 hasConcept C24890656 @default.
• W2891669949 hasConcept C2777056448 @default.
• W2891669949 hasConcept C2780026642 @default.
• W2891669949 hasConcept C2780610907 @default.
• W2891669949 hasConcept C43617362 @default.
• W2891669949 hasConcept C55493867 @default.
• W2891669949 hasConcept C62231903 @default.
• W2891669949 hasConcept C71924100 @default.
• W2891669949 hasConcept C89311334 @default.
• W2891669949 hasConcept C98274493 @default.
• W2891669949 hasConceptScore W2891669949C10146269 @default.
• W2891669949 hasConceptScore W2891669949C112705442 @default.
• W2891669949 hasConceptScore W2891669949C121332964 @default.
• W2891669949 hasConceptScore W2891669949C125287762 @default.
• W2891669949 hasConceptScore W2891669949C179998833 @default.
• W2891669949 hasConceptScore W2891669949C184235292 @default.
• W2891669949 hasConceptScore W2891669949C185592680 @default.
• W2891669949 hasConceptScore W2891669949C24890656 @default.
• W2891669949 hasConceptScore W2891669949C2777056448 @default.
• W2891669949 hasConceptScore W2891669949C2780026642 @default.
• W2891669949 hasConceptScore W2891669949C2780610907 @default.
• W2891669949 hasConceptScore W2891669949C43617362 @default.
• W2891669949 hasConceptScore W2891669949C55493867 @default.
• W2891669949 hasConceptScore W2891669949C62231903 @default.
• W2891669949 hasConceptScore W2891669949C71924100 @default.
• W2891669949 hasConceptScore W2891669949C89311334 @default.
• W2891669949 hasConceptScore W2891669949C98274493 @default.
• W2891669949 hasIssue "8" @default.
• W2891669949 hasLocation W28916699491 @default.
• W2891669949 hasLocation W28916699492 @default.
• W2891669949 hasLocation W28916699493 @default.
• W2891669949 hasOpenAccess W2891669949 @default.
• W2891669949 hasPrimaryLocation W28916699491 @default.
• W2891669949 hasRelatedWork W1491964893 @default.
• W2891669949 hasRelatedWork W1925982542 @default.
• W2891669949 hasRelatedWork W1969876219 @default.
• W2891669949 hasRelatedWork W2009246547 @default.
• W2891669949 hasRelatedWork W2045937169 @default.
• W2891669949 hasRelatedWork W2124881865 @default.
• W2891669949 hasRelatedWork W2244507257 @default.
• W2891669949 hasRelatedWork W2318353920 @default.
• W2891669949 hasRelatedWork W2397907227 @default.
• W2891669949 hasRelatedWork W56168861 @default.
• W2891669949 hasVolume "49" @default.
• W2891669949 isParatext "false" @default.

• next