FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891670573> ?p ?o ?g. }

• W2891670573 abstract "Dual antiplatelet therapy (DAPT) varies after placement of drug-eluting stents (DES) in patients presenting with acute coronary syndromes (ACS). Our aim was to study patient characteristics and predictors of switching, in-hospital or at discharge, from clopidogrel (CLO) to ticagrelor (TIC) or vice versa.The study population included patients with ACS who had DES and initially received either CLO or TIC between January 2011 and December 2017. Patients were divided into 4 groups based on initial DAPT choice and whether DAPT was switched in-hospital or during discharge. Clinical outcomes of interest were bleeding events, need for anticoagulation, and need for in-hospital coronary artery bypass graft (CABG).We identified 2837 patients who received DES and started on DAPT. DAPT switch from 1 P2Y12 inhibitor to another occurred in 9%, either in-hospital or at discharge. Of 1834 patients started on CLO, 112 were switched to TIC. Of 1003 patients started on TIC, 142 were switched to CLO. The need for in-hospital CABG was 7.8% in the TIC-CLO group compared to none in the CLO-TIC group (p = 0.002). Adjusted for covariates, the TIC-CLO group was 3 times more likely to need anticoagulation with warfarin than the CLO-CLO group (p < 0.001) and over 5 times more likely than the CLO-TIC group and the TIC-TIC group (p < 0.005 for both).Switching from 1 generation P2Y12 inhibitor to another does occur in ACS patients. Clinical needs such as in-hospital CABG or oral anticoagulation upon discharge are real and dictate the switch from TIC to CLO.A single-center observational study of 2837 patients with acute coronary syndromes treated with drug-eluting stents found that some do get switched from one generation P2Y12 inhibitor to another. The switch from clopidogrel to ticagrelor is driven by clinical needs such as in-hospital coronary artery bypass grafting or the need for oral anticoagulation upon discharge." @default.
• W2891670573 created "2018-09-27" @default.
• W2891670573 creator A5002279235 @default.
• W2891670573 creator A5007473059 @default.
• W2891670573 creator A5023256291 @default.
• W2891670573 creator A5032478554 @default.
• W2891670573 creator A5033532434 @default.
• W2891670573 creator A5037371281 @default.
• W2891670573 creator A5041078676 @default.
• W2891670573 creator A5044901123 @default.
• W2891670573 creator A5046457452 @default.
• W2891670573 creator A5049224966 @default.
• W2891670573 creator A5051975336 @default.
• W2891670573 creator A5052993534 @default.
• W2891670573 creator A5087218118 @default.
• W2891670573 date "2018-12-01" @default.
• W2891670573 modified "2023-10-18" @default.
• W2891670573 title "The impact of in-hospital P2Y12 inhibitor switch in patients with acute coronary syndrome" @default.
• W2891670573 cites W1553345686 @default.
• W2891670573 cites W1985354955 @default.
• W2891670573 cites W2017059309 @default.
• W2891670573 cites W2046973755 @default.
• W2891670573 cites W2053379248 @default.
• W2891670573 cites W2087150869 @default.
• W2891670573 cites W2087629782 @default.
• W2891670573 cites W2105397247 @default.
• W2891670573 cites W2112380741 @default.
• W2891670573 cites W2136085304 @default.
• W2891670573 cites W2140501627 @default.
• W2891670573 cites W2141358924 @default.
• W2891670573 cites W2149011208 @default.
• W2891670573 cites W2166950143 @default.
• W2891670573 cites W2169387542 @default.
• W2891670573 cites W2754054868 @default.
• W2891670573 cites W2756990792 @default.
• W2891670573 cites W2806396098 @default.
• W2891670573 doi "https://doi.org/10.1016/j.carrev.2018.09.007" @default.
• W2891670573 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30243963" @default.
• W2891670573 hasPublicationYear "2018" @default.
• W2891670573 type Work @default.
• W2891670573 sameAs 2891670573 @default.
• W2891670573 citedByCount "5" @default.
• W2891670573 countsByYear W28916705732018 @default.
• W2891670573 countsByYear W28916705732020 @default.
• W2891670573 countsByYear W28916705732022 @default.
• W2891670573 crossrefType "journal-article" @default.
• W2891670573 hasAuthorship W2891670573A5002279235 @default.
• W2891670573 hasAuthorship W2891670573A5007473059 @default.
• W2891670573 hasAuthorship W2891670573A5023256291 @default.
• W2891670573 hasAuthorship W2891670573A5032478554 @default.
• W2891670573 hasAuthorship W2891670573A5033532434 @default.
• W2891670573 hasAuthorship W2891670573A5037371281 @default.
• W2891670573 hasAuthorship W2891670573A5041078676 @default.
• W2891670573 hasAuthorship W2891670573A5044901123 @default.
• W2891670573 hasAuthorship W2891670573A5046457452 @default.
• W2891670573 hasAuthorship W2891670573A5049224966 @default.
• W2891670573 hasAuthorship W2891670573A5051975336 @default.
• W2891670573 hasAuthorship W2891670573A5052993534 @default.
• W2891670573 hasAuthorship W2891670573A5087218118 @default.
• W2891670573 hasConcept C126322002 @default.
• W2891670573 hasConcept C164705383 @default.
• W2891670573 hasConcept C2776301958 @default.
• W2891670573 hasConcept C2777698277 @default.
• W2891670573 hasConcept C2777849778 @default.
• W2891670573 hasConcept C2779161974 @default.
• W2891670573 hasConcept C2780890252 @default.
• W2891670573 hasConcept C2908647359 @default.
• W2891670573 hasConcept C3017624810 @default.
• W2891670573 hasConcept C49059817 @default.
• W2891670573 hasConcept C500558357 @default.
• W2891670573 hasConcept C71924100 @default.
• W2891670573 hasConcept C99454951 @default.
• W2891670573 hasConceptScore W2891670573C126322002 @default.
• W2891670573 hasConceptScore W2891670573C164705383 @default.
• W2891670573 hasConceptScore W2891670573C2776301958 @default.
• W2891670573 hasConceptScore W2891670573C2777698277 @default.
• W2891670573 hasConceptScore W2891670573C2777849778 @default.
• W2891670573 hasConceptScore W2891670573C2779161974 @default.
• W2891670573 hasConceptScore W2891670573C2780890252 @default.
• W2891670573 hasConceptScore W2891670573C2908647359 @default.
• W2891670573 hasConceptScore W2891670573C3017624810 @default.
• W2891670573 hasConceptScore W2891670573C49059817 @default.
• W2891670573 hasConceptScore W2891670573C500558357 @default.
• W2891670573 hasConceptScore W2891670573C71924100 @default.
• W2891670573 hasConceptScore W2891670573C99454951 @default.
• W2891670573 hasFunder F4320309139 @default.
• W2891670573 hasFunder F4320310567 @default.
• W2891670573 hasFunder F4320325446 @default.
• W2891670573 hasFunder F4320333259 @default.
• W2891670573 hasLocation W28916705731 @default.
• W2891670573 hasLocation W28916705732 @default.
• W2891670573 hasOpenAccess W2891670573 @default.
• W2891670573 hasPrimaryLocation W28916705731 @default.
• W2891670573 hasRelatedWork W1995953692 @default.
• W2891670573 hasRelatedWork W2060841228 @default.
• W2891670573 hasRelatedWork W2154453645 @default.
• W2891670573 hasRelatedWork W2412620152 @default.
• W2891670573 hasRelatedWork W2434380400 @default.
• W2891670573 hasRelatedWork W2970212640 @default.
• W2891670573 hasRelatedWork W2978445477 @default.

• next