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- W2891671105 abstract "Methanobacterium formicicum (Methanobacteriaceae family) is an endosymbiotic methanogenic Archaean found in the digestive tracts of ruminants and elsewhere. It has been significantly implicated in global CH4 emission during enteric fermentation processes. In this review, we discuss current genomic and metabolic aspects of this microorganism for the purpose of the discovery of novel veterinary therapeutics. This microorganism encompasses a typical H2 scavenging system, which facilitates a metabolic symbiosis across the H2 producing cellulolytic bacteria and fumarate reducing bacteria. To date, five genome-scale metabolic models (iAF692, iMG746, iMB745, iVS941 and iMM518) have been developed. These metabolic reconstructions revealed the cellular and metabolic behaviors of methanogenic archaea. The characteristics of its symbiotic behavior and metabolic crosstalk with competitive rumen anaerobes support understanding of the physiological function and metabolic fate of shared metabolites in the rumen ecosystem. Thus, systems biological characterization of this microorganism may provide a new insight to realize its metabolic significance for the development of a healthy microbiota in ruminants. An in-depth knowledge of this microorganism may allow us to ensure a long term sustainability of ruminant-based agriculture." @default.
- W2891671105 created "2018-09-27" @default.
- W2891671105 creator A5041438163 @default.
- W2891671105 creator A5046003810 @default.
- W2891671105 creator A5050336383 @default.
- W2891671105 creator A5057800074 @default.
- W2891671105 date "2018-12-01" @default.
- W2891671105 modified "2023-10-18" @default.
- W2891671105 title "Methanobacterium formicicum as a target rumen methanogen for the development of new methane mitigation interventions: A review" @default.
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