FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891674619> ?p ?o ?g. }

• W2891674619 endingPage "1624" @default.
• W2891674619 startingPage "1614" @default.
• W2891674619 abstract "Recent experimental studies of the role of microtubule sliding in neurite outgrowth suggested a qualitative model, according to which kinesin-1 motors push the minus-end-out microtubules against the cell membrane and generate the early cell processes. At the later stage, dynein takes over the sliding, expels the minus-end-out microtubules from the neurites, and pulls in the plus-end-out microtubules that continue to elongate the nascent axon. This model leaves unanswered a number of questions: why is dynein unable to generate the processes alone, whereas kinesin-1 can? What is the role of microtubule dynamics in process initiation and growth? Can the model correctly predict the rates of process growth in control and dynein-inhibited cases? What triggers the transition from kinesin-driven to dynein-driven sliding? To answer these questions, we combine computational modeling of a network of elastic dynamic microtubules and kinesin-1 and dynein motors with measurements of the process growth kinetics and pharmacological perturbations in Drosophila S2 cells. The results verify quantitatively the qualitative model of the microtubule polarity sorting and suggest that dynein-powered elongation is effective only when the processes are longer than a threshold length, which explains why kinesin-1 alone, but not dynein, is sufficient for the process growth. Furthermore, we show that the mechanism of process elongation depends critically on microtubule dynamic instability. Both modeling and experimental measurements show, surprisingly, that dynein inhibition accelerates the process extension. We discuss implications of the model for the general problems of cell polarization, cytoskeletal polarity emergence, and cell process protrusion." @default.
• W2891674619 created "2018-09-27" @default.
• W2891674619 creator A5033899417 @default.
• W2891674619 creator A5038860915 @default.
• W2891674619 creator A5053378640 @default.
• W2891674619 creator A5079796040 @default.
• W2891674619 date "2018-10-01" @default.
• W2891674619 modified "2023-10-06" @default.
• W2891674619 title "Microtubule Dynamics, Kinesin-1 Sliding, and Dynein Action Drive Growth of Cell Processes" @default.
• W2891674619 cites W1503265874 @default.
• W2891674619 cites W1565036272 @default.
• W2891674619 cites W1968393513 @default.
• W2891674619 cites W1970797137 @default.
• W2891674619 cites W1974380358 @default.
• W2891674619 cites W1985663248 @default.
• W2891674619 cites W1992045321 @default.
• W2891674619 cites W2001280618 @default.
• W2891674619 cites W2009368968 @default.
• W2891674619 cites W2011924132 @default.
• W2891674619 cites W2014019038 @default.
• W2891674619 cites W2018325420 @default.
• W2891674619 cites W2026750744 @default.
• W2891674619 cites W2038523703 @default.
• W2891674619 cites W2043415140 @default.
• W2891674619 cites W2045066968 @default.
• W2891674619 cites W2047512850 @default.
• W2891674619 cites W2049285713 @default.
• W2891674619 cites W2072335754 @default.
• W2891674619 cites W2073510453 @default.
• W2891674619 cites W2074393382 @default.
• W2891674619 cites W2075376229 @default.
• W2891674619 cites W2079175432 @default.
• W2891674619 cites W2081531192 @default.
• W2891674619 cites W2092078018 @default.
• W2891674619 cites W2095148733 @default.
• W2891674619 cites W2098956081 @default.
• W2891674619 cites W2114194300 @default.
• W2891674619 cites W2115378800 @default.
• W2891674619 cites W2126581291 @default.
• W2891674619 cites W2138378914 @default.
• W2891674619 cites W2145230026 @default.
• W2891674619 cites W2145602847 @default.
• W2891674619 cites W2146444505 @default.
• W2891674619 cites W2149762749 @default.
• W2891674619 cites W2151512547 @default.
• W2891674619 cites W2158190317 @default.
• W2891674619 cites W2160749505 @default.
• W2891674619 cites W2162643935 @default.
• W2891674619 cites W2162984490 @default.
• W2891674619 cites W2173897519 @default.
• W2891674619 cites W2188534067 @default.
• W2891674619 cites W2201989124 @default.
• W2891674619 cites W2209140502 @default.
• W2891674619 cites W2248624084 @default.
• W2891674619 cites W2263074113 @default.
• W2891674619 cites W2265915648 @default.
• W2891674619 cites W2276736055 @default.
• W2891674619 cites W2290132634 @default.
• W2891674619 cites W2294670569 @default.
• W2891674619 cites W2336101489 @default.
• W2891674619 cites W2345410528 @default.
• W2891674619 cites W2462955862 @default.
• W2891674619 cites W2474358850 @default.
• W2891674619 cites W2481400385 @default.
• W2891674619 cites W2502130428 @default.
• W2891674619 cites W2527190224 @default.
• W2891674619 cites W2530922389 @default.
• W2891674619 cites W2593246002 @default.
• W2891674619 cites W2601548771 @default.
• W2891674619 cites W2618261562 @default.
• W2891674619 cites W2625130610 @default.
• W2891674619 cites W2758801732 @default.
• W2891674619 cites W2761613006 @default.
• W2891674619 cites W2771928043 @default.
• W2891674619 cites W2772529720 @default.
• W2891674619 cites W3104551298 @default.
• W2891674619 doi "https://doi.org/10.1016/j.bpj.2018.08.046" @default.
• W2891674619 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6260207" @default.
• W2891674619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30268540" @default.
• W2891674619 hasPublicationYear "2018" @default.
• W2891674619 type Work @default.
• W2891674619 sameAs 2891674619 @default.
• W2891674619 citedByCount "16" @default.
• W2891674619 countsByYear W28916746192019 @default.
• W2891674619 countsByYear W28916746192020 @default.
• W2891674619 countsByYear W28916746192021 @default.
• W2891674619 countsByYear W28916746192022 @default.
• W2891674619 countsByYear W28916746192023 @default.
• W2891674619 crossrefType "journal-article" @default.
• W2891674619 hasAuthorship W2891674619A5033899417 @default.
• W2891674619 hasAuthorship W2891674619A5038860915 @default.
• W2891674619 hasAuthorship W2891674619A5053378640 @default.
• W2891674619 hasAuthorship W2891674619A5079796040 @default.
• W2891674619 hasBestOaLocation W28916746191 @default.
• W2891674619 hasConcept C106987784 @default.
• W2891674619 hasConcept C12554922 @default.
• W2891674619 hasConcept C20418707 @default.
• W2891674619 hasConcept C59006786 @default.

• next