FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891680869> ?p ?o ?g. }

• W2891680869 endingPage "3659" @default.
• W2891680869 startingPage "3651" @default.
• W2891680869 abstract "Purpose: The aim of this study was to generate a novel miRNA expression signature to effectively assess nodal metastasis, distant metastasis and predict prognosis for patients with kidney renal clear cell carcinoma (KIRC) and explore its potential mechanism of affecting the prognosis. Method: Using expression profiles downloaded from the Cancer Genome Atlas database, we identified multiple miRNAs with differential expression between KIRC and paired normal tissues. The diagnostic values of the differentially expressed miRNAs for nodal metastasis and distant metastasis were evaluated by Receiver Operating Characteristic (ROC) curve analysis. Then, we evaluated the impact of miRNAs on overall survival (OS) by univariate and multivariate COX regression analyzes. This analysis was ultimately used to construct a miRNA signature that effectively assessed nodal metastasis, distant metastasis and predicted prognosis. The functional enrichment analysis of the miRNAs included in the signatures was used to explore its potential molecular mechanism in KIRC. Results: Based on our cutoff criteria (P < 0.05 and |log2FC| > 1.0), we identified 104 differentially expressed microRNAs (miRNAs), including 43 that were up-regulated in KIRC tissues and 61 that were down-regulated. We found 12 miRNAs were potentially diagnostic biomarkers of nodal metastasis and distant metastasis by ROC curve analysis. Two miRNAs (miRNA-21 and miRNA-223) were significant miRNAs independently associated with OS based on Cox univariate and multivariate analysis. We generated a signature index based on expression of these two miRNAs, and the two-miRNA signature is promising as a biomarker for diagnosing nodal metastasis, distant metastasis and predicting 5-year survival rate of KIRC with areas under the curve (AUC)=0.738, 0.659 and 0.731, respectively. Patients were stratified into high-risk and low-risk groups, according to median of the signature prognosis indexes. Patients in the high-risk group had significantly shorter survival times than those in the low-risk group (P = 0.000). The functional enrichment analysis suggested that the target genes of two miRNAs may be involved in various pathways related to cancer, p53 signaling pathway, apoptosis, and MAPK signaling pathway. Conclusion: The two-miRNA signature could assess nodal metastasis, distant metastasis and predict survival of KIRC. As a promising prediction tool, the mechanism of the two miRNAs in KIRC deserves further study." @default.
• W2891680869 created "2018-09-27" @default.
• W2891680869 creator A5017108072 @default.
• W2891680869 creator A5022244759 @default.
• W2891680869 creator A5035640493 @default.
• W2891680869 creator A5036645166 @default.
• W2891680869 creator A5037881843 @default.
• W2891680869 creator A5058205856 @default.
• W2891680869 creator A5064803348 @default.
• W2891680869 creator A5072809229 @default.
• W2891680869 creator A5083316180 @default.
• W2891680869 creator A5084894800 @default.
• W2891680869 creator A5088326920 @default.
• W2891680869 date "2018-01-01" @default.
• W2891680869 modified "2023-10-17" @default.
• W2891680869 title "miRNA-21 and miRNA-223 expression signature as a predictor for lymph node metastasis, distant metastasis and survival in kidney renal clear cell carcinoma" @default.
• W2891680869 cites W1915855266 @default.
• W2891680869 cites W1974254202 @default.
• W2891680869 cites W1981859869 @default.
• W2891680869 cites W1983922487 @default.
• W2891680869 cites W1997952673 @default.
• W2891680869 cites W2006617902 @default.
• W2891680869 cites W2012647532 @default.
• W2891680869 cites W2021964072 @default.
• W2891680869 cites W2036572356 @default.
• W2891680869 cites W2064072638 @default.
• W2891680869 cites W2069480574 @default.
• W2891680869 cites W2094720383 @default.
• W2891680869 cites W2098215003 @default.
• W2891680869 cites W2123664981 @default.
• W2891680869 cites W2130876393 @default.
• W2891680869 cites W2130979840 @default.
• W2891680869 cites W2137970869 @default.
• W2891680869 cites W2146512944 @default.
• W2891680869 cites W2148741545 @default.
• W2891680869 cites W2150610487 @default.
• W2891680869 cites W2157120864 @default.
• W2891680869 cites W2158025958 @default.
• W2891680869 cites W2159675211 @default.
• W2891680869 cites W2171296186 @default.
• W2891680869 cites W2173254139 @default.
• W2891680869 cites W2235523093 @default.
• W2891680869 cites W2341117915 @default.
• W2891680869 cites W2515333140 @default.
• W2891680869 cites W2524588048 @default.
• W2891680869 cites W2543054850 @default.
• W2891680869 cites W2570618306 @default.
• W2891680869 cites W2573152477 @default.
• W2891680869 cites W2731860601 @default.
• W2891680869 doi "https://doi.org/10.7150/jca.27117" @default.
• W2891680869 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6216006" @default.
• W2891680869 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30405833" @default.
• W2891680869 hasPublicationYear "2018" @default.
• W2891680869 type Work @default.
• W2891680869 sameAs 2891680869 @default.
• W2891680869 citedByCount "25" @default.
• W2891680869 countsByYear W28916808692019 @default.
• W2891680869 countsByYear W28916808692020 @default.
• W2891680869 countsByYear W28916808692021 @default.
• W2891680869 countsByYear W28916808692022 @default.
• W2891680869 countsByYear W28916808692023 @default.
• W2891680869 crossrefType "journal-article" @default.
• W2891680869 hasAuthorship W2891680869A5017108072 @default.
• W2891680869 hasAuthorship W2891680869A5022244759 @default.
• W2891680869 hasAuthorship W2891680869A5035640493 @default.
• W2891680869 hasAuthorship W2891680869A5036645166 @default.
• W2891680869 hasAuthorship W2891680869A5037881843 @default.
• W2891680869 hasAuthorship W2891680869A5058205856 @default.
• W2891680869 hasAuthorship W2891680869A5064803348 @default.
• W2891680869 hasAuthorship W2891680869A5072809229 @default.
• W2891680869 hasAuthorship W2891680869A5083316180 @default.
• W2891680869 hasAuthorship W2891680869A5084894800 @default.
• W2891680869 hasAuthorship W2891680869A5088326920 @default.
• W2891680869 hasBestOaLocation W28916808691 @default.
• W2891680869 hasConcept C104317684 @default.
• W2891680869 hasConcept C10515644 @default.
• W2891680869 hasConcept C121608353 @default.
• W2891680869 hasConcept C126322002 @default.
• W2891680869 hasConcept C142724271 @default.
• W2891680869 hasConcept C143998085 @default.
• W2891680869 hasConcept C145059251 @default.
• W2891680869 hasConcept C2777472916 @default.
• W2891680869 hasConcept C2779013556 @default.
• W2891680869 hasConcept C2781197716 @default.
• W2891680869 hasConcept C2781278892 @default.
• W2891680869 hasConcept C502942594 @default.
• W2891680869 hasConcept C50382708 @default.
• W2891680869 hasConcept C54355233 @default.
• W2891680869 hasConcept C58471807 @default.
• W2891680869 hasConcept C71924100 @default.
• W2891680869 hasConcept C86803240 @default.
• W2891680869 hasConceptScore W2891680869C104317684 @default.
• W2891680869 hasConceptScore W2891680869C10515644 @default.
• W2891680869 hasConceptScore W2891680869C121608353 @default.
• W2891680869 hasConceptScore W2891680869C126322002 @default.
• W2891680869 hasConceptScore W2891680869C142724271 @default.
• W2891680869 hasConceptScore W2891680869C143998085 @default.
• W2891680869 hasConceptScore W2891680869C145059251 @default.

• next