FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891683224> ?p ?o ?g. }

• W2891683224 abstract "Abstract Processing incentive and drive is essential for control of goal-directed behavior. The limbic part of the basal ganglia has been emphasized in these processes, yet the exact neuronal mechanism has remained elusive. In this study, we examined the neuronal activity of the ventral pallidum (VP) and its upstream area, the rostromedial caudate (rmCD), while two male macaque monkeys performed an instrumental lever-release task, in which a visual cue indicated the forthcoming reward size. We found that the activity of some neurons in VP and rmCD reflected the expected reward-size transiently following the cue. Reward-size coding appeared earlier and stronger in VP than in rmCD. We also found that the activity in these areas was modulated by the satiation level of monkeys, which also occurred more frequently in VP than in rmCD. The information regarding reward-size and satiation-level was independently signaled in the neuronal populations of these areas. The data thus highlighted the neuronal coding of key variables for goal-directed behavior in VP. Furthermore, pharmacological inactivation of VP induced more severe deficit of goal-directed behavior than inactivation of rmCD, which was indicated by abnormal error repetition and diminished satiation effect on the performance. These results suggest that VP encodes incentive value and internal drive, and plays a pivotal role in the control of motivation to promote goal-directed behavior. Significance Statement The limbic part of the basal ganglia has been emphasized in the motivational control of goal-directed action. Here, we investigated how the ventral pallidum (VP) and the rostromedial caudate (rmCD) encode incentive value and internal drive, and control goal-directed behavior. Neuronal recording and subsequent pharmacological inactivation revealed that VP had stronger coding of reward size and satiation level than rmCD. Reward size and satiation level were independently encoded in the neuronal population of these areas. Furthermore, VP inactivation impaired goal-directed behavior more severely than rmCD inactivation. These results highlighted the central role of VP in the motivational control of goal-directed action." @default.
• W2891683224 created "2018-09-27" @default.
• W2891683224 creator A5005037544 @default.
• W2891683224 creator A5021482868 @default.
• W2891683224 creator A5048816474 @default.
• W2891683224 creator A5059642319 @default.
• W2891683224 creator A5066421492 @default.
• W2891683224 creator A5085282537 @default.
• W2891683224 creator A5085556975 @default.
• W2891683224 date "2018-09-18" @default.
• W2891683224 modified "2023-09-27" @default.
• W2891683224 title "Signaling incentive and drive in the primate ventral pallidum for motivational control of goal-directed action" @default.
• W2891683224 cites W1510847502 @default.
• W2891683224 cites W1511786579 @default.
• W2891683224 cites W1546234970 @default.
• W2891683224 cites W1766116129 @default.
• W2891683224 cites W1776740662 @default.
• W2891683224 cites W1893851251 @default.
• W2891683224 cites W1971359921 @default.
• W2891683224 cites W1973664608 @default.
• W2891683224 cites W1974058328 @default.
• W2891683224 cites W1986262823 @default.
• W2891683224 cites W1995214286 @default.
• W2891683224 cites W1996692756 @default.
• W2891683224 cites W2008486927 @default.
• W2891683224 cites W2020361904 @default.
• W2891683224 cites W2022104671 @default.
• W2891683224 cites W2023732657 @default.
• W2891683224 cites W2025507160 @default.
• W2891683224 cites W2034128529 @default.
• W2891683224 cites W2035803106 @default.
• W2891683224 cites W2047471489 @default.
• W2891683224 cites W2054749214 @default.
• W2891683224 cites W2060810779 @default.
• W2891683224 cites W2065445243 @default.
• W2891683224 cites W2070069117 @default.
• W2891683224 cites W2070485861 @default.
• W2891683224 cites W2073346596 @default.
• W2891683224 cites W2083537735 @default.
• W2891683224 cites W2092075435 @default.
• W2891683224 cites W2097552217 @default.
• W2891683224 cites W2101448098 @default.
• W2891683224 cites W2104822204 @default.
• W2891683224 cites W2112350022 @default.
• W2891683224 cites W2113616846 @default.
• W2891683224 cites W2115998792 @default.
• W2891683224 cites W2124103130 @default.
• W2891683224 cites W2127120806 @default.
• W2891683224 cites W2128472904 @default.
• W2891683224 cites W2129362735 @default.
• W2891683224 cites W2135505898 @default.
• W2891683224 cites W2144079442 @default.
• W2891683224 cites W2147878454 @default.
• W2891683224 cites W2154574407 @default.
• W2891683224 cites W2156952192 @default.
• W2891683224 cites W2170396337 @default.
• W2891683224 cites W2199533381 @default.
• W2891683224 cites W2334348929 @default.
• W2891683224 cites W2344289043 @default.
• W2891683224 cites W2399921396 @default.
• W2891683224 cites W2406024906 @default.
• W2891683224 cites W2437388468 @default.
• W2891683224 cites W2493630655 @default.
• W2891683224 cites W2529608724 @default.
• W2891683224 cites W2560387223 @default.
• W2891683224 cites W2793116051 @default.
• W2891683224 cites W2801790580 @default.
• W2891683224 cites W4241696300 @default.
• W2891683224 doi "https://doi.org/10.1101/420851" @default.
• W2891683224 hasPublicationYear "2018" @default.
• W2891683224 type Work @default.
• W2891683224 sameAs 2891683224 @default.
• W2891683224 citedByCount "0" @default.
• W2891683224 crossrefType "posted-content" @default.
• W2891683224 hasAuthorship W2891683224A5005037544 @default.
• W2891683224 hasAuthorship W2891683224A5021482868 @default.
• W2891683224 hasAuthorship W2891683224A5048816474 @default.
• W2891683224 hasAuthorship W2891683224A5059642319 @default.
• W2891683224 hasAuthorship W2891683224A5066421492 @default.
• W2891683224 hasAuthorship W2891683224A5085282537 @default.
• W2891683224 hasAuthorship W2891683224A5085556975 @default.
• W2891683224 hasBestOaLocation W28916832241 @default.
• W2891683224 hasConcept C15744967 @default.
• W2891683224 hasConcept C169760540 @default.
• W2891683224 hasConcept C2778187257 @default.
• W2891683224 hasConcept C2778738651 @default.
• W2891683224 hasConcept C2778950215 @default.
• W2891683224 hasConcept C2779305214 @default.
• W2891683224 hasConcept C2780278869 @default.
• W2891683224 hasConcept C529278444 @default.
• W2891683224 hasConcept C74254510 @default.
• W2891683224 hasConcept C77805123 @default.
• W2891683224 hasConcept C86803240 @default.
• W2891683224 hasConceptScore W2891683224C15744967 @default.
• W2891683224 hasConceptScore W2891683224C169760540 @default.
• W2891683224 hasConceptScore W2891683224C2778187257 @default.
• W2891683224 hasConceptScore W2891683224C2778738651 @default.
• W2891683224 hasConceptScore W2891683224C2778950215 @default.
• W2891683224 hasConceptScore W2891683224C2779305214 @default.
• W2891683224 hasConceptScore W2891683224C2780278869 @default.

• next