FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891684226> ?p ?o ?g. }

• W2891684226 abstract "High-dose radiation-induced tissue damage is a major limiting factor in the medical application of nuclear technology. Herein, we tested 28-day repeated-dose toxicity of KMRC011, an agonist of toll-like receptor (TLR) 5, which is being developed as a medical countermeasure for radiation, using cynomolgus monkeys. KMRC011 (0.01, 0.02 or 0.04 mg/kg/day) was intramuscularly injected once daily for 4 weeks, and each two monkeys in both control and 0.04 mg/kg/day group were observed for an additional 2-week recovery period. There were no dose-related toxicological changes in mortality, clinical observations, body weight, food consumption, ophthalmological findings, electrocardiographs, coagulation, serum chemistry, organ weights, or urinalysis and urine chemistry. Although treatment-related changes, such as increased white blood cells, increased absolute and relative neutrophils, decreased relative lymphocytes and inflammatory lesions, were noted in the maximum dose group, these findings were not observed after the 2-week recovery period. Further, we considered that the kidneys and heart may be target organs of TLR5 agonists, as well as the spleen, and that autophagic signals can be triggered in tissue damage and the repair process. Importantly, accumulation of p62 protein, an indicator of autophagy, and a decrease of caveolin-1 protein, a regulator of TLR5 protein half-life, were found in both tissues from the highest dose group. Therefore, we conclude that the no-observed-adverse-effect level for KMRC011 may be greater than 0.04 mg/kg/day in male and female monkeys. Additionally, we propose that further studies are needed to identify the molecular signals, which are related to KMRC011-induced adverse effects." @default.
• W2891684226 created "2018-09-27" @default.
• W2891684226 creator A5004888873 @default.
• W2891684226 creator A5013508257 @default.
• W2891684226 creator A5015438596 @default.
• W2891684226 creator A5019131632 @default.
• W2891684226 creator A5020227806 @default.
• W2891684226 creator A5027989015 @default.
• W2891684226 creator A5038976110 @default.
• W2891684226 creator A5051110035 @default.
• W2891684226 creator A5065169581 @default.
• W2891684226 creator A5087664139 @default.
• W2891684226 date "2018-09-11" @default.
• W2891684226 modified "2023-09-24" @default.
• W2891684226 title "Repeated injection of KMRC011, a medical countermeasure for radiation, can cause adverse health effects in cynomolgus monkeys" @default.
• W2891684226 cites W1486395196 @default.
• W2891684226 cites W1543695514 @default.
• W2891684226 cites W1780653824 @default.
• W2891684226 cites W1971254854 @default.
• W2891684226 cites W1973988617 @default.
• W2891684226 cites W1976770085 @default.
• W2891684226 cites W1992750070 @default.
• W2891684226 cites W1993865500 @default.
• W2891684226 cites W2017237401 @default.
• W2891684226 cites W2023493127 @default.
• W2891684226 cites W2027423197 @default.
• W2891684226 cites W2033591730 @default.
• W2891684226 cites W2039874643 @default.
• W2891684226 cites W2044655200 @default.
• W2891684226 cites W2046564053 @default.
• W2891684226 cites W2076603535 @default.
• W2891684226 cites W2093955093 @default.
• W2891684226 cites W2119431208 @default.
• W2891684226 cites W2136093891 @default.
• W2891684226 cites W2142585879 @default.
• W2891684226 cites W2147100699 @default.
• W2891684226 cites W2149598489 @default.
• W2891684226 cites W2149780938 @default.
• W2891684226 cites W2183193379 @default.
• W2891684226 cites W2548078838 @default.
• W2891684226 cites W2556145730 @default.
• W2891684226 cites W2600785752 @default.
• W2891684226 cites W2607012424 @default.
• W2891684226 cites W2771789368 @default.
• W2891684226 cites W2783982610 @default.
• W2891684226 cites W2803744378 @default.
• W2891684226 cites W2805053653 @default.
• W2891684226 doi "https://doi.org/10.1002/jat.3719" @default.
• W2891684226 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30277593" @default.
• W2891684226 hasPublicationYear "2018" @default.
• W2891684226 type Work @default.
• W2891684226 sameAs 2891684226 @default.
• W2891684226 citedByCount "4" @default.
• W2891684226 countsByYear W28916842262019 @default.
• W2891684226 countsByYear W28916842262020 @default.
• W2891684226 crossrefType "journal-article" @default.
• W2891684226 hasAuthorship W2891684226A5004888873 @default.
• W2891684226 hasAuthorship W2891684226A5013508257 @default.
• W2891684226 hasAuthorship W2891684226A5015438596 @default.
• W2891684226 hasAuthorship W2891684226A5019131632 @default.
• W2891684226 hasAuthorship W2891684226A5020227806 @default.
• W2891684226 hasAuthorship W2891684226A5027989015 @default.
• W2891684226 hasAuthorship W2891684226A5038976110 @default.
• W2891684226 hasAuthorship W2891684226A5051110035 @default.
• W2891684226 hasAuthorship W2891684226A5065169581 @default.
• W2891684226 hasAuthorship W2891684226A5087664139 @default.
• W2891684226 hasConcept C126322002 @default.
• W2891684226 hasConcept C197934379 @default.
• W2891684226 hasConcept C2779225474 @default.
• W2891684226 hasConcept C2780026642 @default.
• W2891684226 hasConcept C29730261 @default.
• W2891684226 hasConcept C42407357 @default.
• W2891684226 hasConcept C71924100 @default.
• W2891684226 hasConcept C98274493 @default.
• W2891684226 hasConceptScore W2891684226C126322002 @default.
• W2891684226 hasConceptScore W2891684226C197934379 @default.
• W2891684226 hasConceptScore W2891684226C2779225474 @default.
• W2891684226 hasConceptScore W2891684226C2780026642 @default.
• W2891684226 hasConceptScore W2891684226C29730261 @default.
• W2891684226 hasConceptScore W2891684226C42407357 @default.
• W2891684226 hasConceptScore W2891684226C71924100 @default.
• W2891684226 hasConceptScore W2891684226C98274493 @default.
• W2891684226 hasLocation W28916842261 @default.
• W2891684226 hasLocation W28916842262 @default.
• W2891684226 hasOpenAccess W2891684226 @default.
• W2891684226 hasPrimaryLocation W28916842261 @default.
• W2891684226 hasRelatedWork W1986113350 @default.
• W2891684226 hasRelatedWork W1993246187 @default.
• W2891684226 hasRelatedWork W2004003034 @default.
• W2891684226 hasRelatedWork W2025480341 @default.
• W2891684226 hasRelatedWork W2039378943 @default.
• W2891684226 hasRelatedWork W2071933152 @default.
• W2891684226 hasRelatedWork W2099626796 @default.
• W2891684226 hasRelatedWork W2132960688 @default.
• W2891684226 hasRelatedWork W2945522913 @default.
• W2891684226 hasRelatedWork W3200281013 @default.
• W2891684226 isParatext "false" @default.
• W2891684226 isRetracted "false" @default.
• W2891684226 magId "2891684226" @default.
• W2891684226 workType "article" @default.