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- W2891685206 abstract "Here we review how immune activation and insulin resistance contribute to the metabolic alterations observed in HIV-infected patients, and how these alterations increase the risk of developing CVD. The introduction and evolution of antiretroviral drugs over the past 25 years has completely changed the clinical prognosis of HIV-infected patients. The deaths of these individuals are now related to atherosclerotic CVDs, rather than from the viral infection itself. However, HIV infection, cART and intestinal microbiota are associated with immune activation and insulin resistance, which can lead to the development of a variety of diseases and disorders, especially with regards to CVDs. The increase in LPS and proinflammatory cytokines circulating levels and intracellular mechanisms activate serine kinases, resulting in insulin receptor substrate-1 (IRS-1) serine phosphorylation and consequently a down regulation in insulin signaling. While lifestyle modifications and pharmaceutical interventions can be employed to treat these altered metabolic functions, the mechanisms involved in the development of these chronic complications remain largely unresolved. The elucidation and understanding of these mechanisms will give rise to new classes of drugs that will further improve the quality of life of HIV-infected patients, over the age of 50." @default.
- W2891685206 created "2018-09-27" @default.
- W2891685206 creator A5000950041 @default.
- W2891685206 creator A5011842474 @default.
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- W2891685206 creator A5061573170 @default.
- W2891685206 creator A5091119942 @default.
- W2891685206 date "2018-09-05" @default.
- W2891685206 modified "2023-10-18" @default.
- W2891685206 title "Insulin Resistance in HIV-Patients: Causes and Consequences" @default.
- W2891685206 cites W1141483185 @default.
- W2891685206 cites W151256503 @default.
- W2891685206 cites W1513634422 @default.
- W2891685206 cites W1534360145 @default.
- W2891685206 cites W1535373147 @default.
- W2891685206 cites W1565839478 @default.
- W2891685206 cites W1573558157 @default.
- W2891685206 cites W1574092316 @default.
- W2891685206 cites W1676263233 @default.
- W2891685206 cites W1807761446 @default.
- W2891685206 cites W1830386925 @default.
- W2891685206 cites W1964226592 @default.
- W2891685206 cites W1965102835 @default.
- W2891685206 cites W1965750048 @default.
- W2891685206 cites W1967548282 @default.
- W2891685206 cites W1968000667 @default.
- W2891685206 cites W1968072656 @default.
- W2891685206 cites W1969122535 @default.
- W2891685206 cites W1975233843 @default.
- W2891685206 cites W1976901934 @default.
- W2891685206 cites W1978444406 @default.
- W2891685206 cites W1981215835 @default.
- W2891685206 cites W1983327119 @default.
- W2891685206 cites W1983335996 @default.
- W2891685206 cites W1985065986 @default.
- W2891685206 cites W1992160694 @default.
- W2891685206 cites W1993015636 @default.
- W2891685206 cites W1994078672 @default.
- W2891685206 cites W1994827009 @default.
- W2891685206 cites W1998660799 @default.
- W2891685206 cites W2005226910 @default.
- W2891685206 cites W2007742356 @default.
- W2891685206 cites W2009172922 @default.
- W2891685206 cites W2011302772 @default.
- W2891685206 cites W2012622658 @default.
- W2891685206 cites W2019894676 @default.
- W2891685206 cites W2021113762 @default.
- W2891685206 cites W2023097793 @default.
- W2891685206 cites W2026616659 @default.
- W2891685206 cites W2028657303 @default.
- W2891685206 cites W2031637294 @default.
- W2891685206 cites W2036495967 @default.
- W2891685206 cites W2038018821 @default.
- W2891685206 cites W2038919513 @default.
- W2891685206 cites W2039340278 @default.
- W2891685206 cites W2042111590 @default.
- W2891685206 cites W2049905679 @default.
- W2891685206 cites W2050654184 @default.
- W2891685206 cites W2052769426 @default.
- W2891685206 cites W2055823448 @default.
- W2891685206 cites W2055833118 @default.
- W2891685206 cites W2058217770 @default.
- W2891685206 cites W2060210361 @default.
- W2891685206 cites W2066690947 @default.
- W2891685206 cites W2069988949 @default.
- W2891685206 cites W2072302043 @default.
- W2891685206 cites W2073552552 @default.
- W2891685206 cites W2073738273 @default.
- W2891685206 cites W2075480536 @default.
- W2891685206 cites W2075711155 @default.
- W2891685206 cites W2079862395 @default.
- W2891685206 cites W2082697314 @default.
- W2891685206 cites W2086163170 @default.
- W2891685206 cites W2088643134 @default.
- W2891685206 cites W2090561336 @default.
- W2891685206 cites W2093504308 @default.
- W2891685206 cites W2101344452 @default.
- W2891685206 cites W2102683312 @default.
- W2891685206 cites W2103266069 @default.
- W2891685206 cites W2110211918 @default.
- W2891685206 cites W2115118763 @default.
- W2891685206 cites W2115944543 @default.
- W2891685206 cites W2119843180 @default.
- W2891685206 cites W2124557952 @default.
- W2891685206 cites W21267726 @default.
- W2891685206 cites W2126892490 @default.
- W2891685206 cites W2127517680 @default.
- W2891685206 cites W2131370688 @default.
- W2891685206 cites W2131536322 @default.
- W2891685206 cites W2132113202 @default.
- W2891685206 cites W2135480835 @default.
- W2891685206 cites W2136683144 @default.
- W2891685206 cites W2136949091 @default.
- W2891685206 cites W2143094770 @default.
- W2891685206 cites W2144153442 @default.
- W2891685206 cites W2144768686 @default.