Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891688056> ?p ?o ?g. }
- W2891688056 startingPage "409854" @default.
- W2891688056 abstract "We previously identified 11 miRNAs which were significantly elevated in the plasma of mothers whose infants were affected by maternal alcohol consumption (Heavily Exposed Affected: HEa) compared to infants who were apparently unaffected by alcohol exposure (Heavily Exposed Unaffected: HEua) or unexposed (UE) controls. These HEa miRNAs were predicted to influence epithelial-mesenchymal transition (EMT), a pathway which is essential for fetal and placental growth and maturation. We now report that prenatal alcohol exposure (PAE) inhibits expression of placental EMT pathway members in rodent and non-human primate voluntary alcohol consumption models. Furthermore, in non-human primates, HEa miRNAs mediated effects of PAE on EMT pathway inhibition. To directly investigate the interaction between HEa miRNAs and ethanol on placenta, we assessed their effects on the cytotrophoblastic BeWO and extravillous/invasive HTR8 human trophoblast cell lines. When administered together, but not separately, HEa miRNAs retarded the cell cycle, significantly impaired expression of core EMT pathway members, and reduced the invasiveness of trophoblasts, pointing to their collective role in modulating the placental growth and invasion deficits seen in PAE. HEa miRNAs additionally interfered with maturation-dependent calcium dynamics, while promoting syncytialization-dependent increases in placental hormone expression. Finally, a single systemic administration of HEa miRNAs, together, to pregnant mice, resulted in decreased fetal and placental growth. Taken together, our data suggests that, following PAE, HEa miRNAs interfere with placental development and disrupt the EMT pathway, thereby contributing to the pathology of Fetal Alcohol Spectrum Disorders." @default.
- W2891688056 created "2018-09-27" @default.
- W2891688056 creator A5003632722 @default.
- W2891688056 creator A5007438752 @default.
- W2891688056 creator A5011464744 @default.
- W2891688056 creator A5026143344 @default.
- W2891688056 creator A5029374094 @default.
- W2891688056 creator A5030987510 @default.
- W2891688056 creator A5039924691 @default.
- W2891688056 creator A5052321572 @default.
- W2891688056 creator A5058299306 @default.
- W2891688056 creator A5074640629 @default.
- W2891688056 creator A5080100227 @default.
- W2891688056 creator A5086539840 @default.
- W2891688056 creator A5086638451 @default.
- W2891688056 creator A5090167927 @default.
- W2891688056 date "2018-09-06" @default.
- W2891688056 modified "2023-09-26" @default.
- W2891688056 title "Maternal Circulating MicroRNAs Control the Placental Response to Alcohol" @default.
- W2891688056 cites W1486010693 @default.
- W2891688056 cites W1494430288 @default.
- W2891688056 cites W1570638334 @default.
- W2891688056 cites W1583945683 @default.
- W2891688056 cites W1665517288 @default.
- W2891688056 cites W1967695018 @default.
- W2891688056 cites W1974527643 @default.
- W2891688056 cites W1975384905 @default.
- W2891688056 cites W1982228076 @default.
- W2891688056 cites W1982254799 @default.
- W2891688056 cites W1982596125 @default.
- W2891688056 cites W1985118237 @default.
- W2891688056 cites W1989207860 @default.
- W2891688056 cites W1992420161 @default.
- W2891688056 cites W1992549746 @default.
- W2891688056 cites W1996455877 @default.
- W2891688056 cites W1999513172 @default.
- W2891688056 cites W2004964281 @default.
- W2891688056 cites W2020366122 @default.
- W2891688056 cites W2023918126 @default.
- W2891688056 cites W2024510213 @default.
- W2891688056 cites W2024893989 @default.
- W2891688056 cites W2025689601 @default.
- W2891688056 cites W2029317114 @default.
- W2891688056 cites W2036015212 @default.
- W2891688056 cites W2036739721 @default.
- W2891688056 cites W2040498637 @default.
- W2891688056 cites W2042871312 @default.
- W2891688056 cites W2052050297 @default.
- W2891688056 cites W2055698030 @default.
- W2891688056 cites W2056807152 @default.
- W2891688056 cites W2062700681 @default.
- W2891688056 cites W2068399828 @default.
- W2891688056 cites W2070363305 @default.
- W2891688056 cites W2074229592 @default.
- W2891688056 cites W2075968335 @default.
- W2891688056 cites W2076422661 @default.
- W2891688056 cites W2080716798 @default.
- W2891688056 cites W2085121027 @default.
- W2891688056 cites W2085719911 @default.
- W2891688056 cites W2088987346 @default.
- W2891688056 cites W2089437140 @default.
- W2891688056 cites W2092023996 @default.
- W2891688056 cites W2108839779 @default.
- W2891688056 cites W2109998353 @default.
- W2891688056 cites W2110292482 @default.
- W2891688056 cites W2112189831 @default.
- W2891688056 cites W2112857121 @default.
- W2891688056 cites W2113511096 @default.
- W2891688056 cites W2114082078 @default.
- W2891688056 cites W2131752910 @default.
- W2891688056 cites W2135973311 @default.
- W2891688056 cites W2136322496 @default.
- W2891688056 cites W2145203015 @default.
- W2891688056 cites W2147371503 @default.
- W2891688056 cites W2149755517 @default.
- W2891688056 cites W2152948116 @default.
- W2891688056 cites W2157916750 @default.
- W2891688056 cites W2160348817 @default.
- W2891688056 cites W2161029943 @default.
- W2891688056 cites W2161729767 @default.
- W2891688056 cites W2164754340 @default.
- W2891688056 cites W2165450984 @default.
- W2891688056 cites W2167279371 @default.
- W2891688056 cites W2167924668 @default.
- W2891688056 cites W2167950650 @default.
- W2891688056 cites W2168524173 @default.
- W2891688056 cites W2175048491 @default.
- W2891688056 cites W2189664213 @default.
- W2891688056 cites W2226494969 @default.
- W2891688056 cites W2258017452 @default.
- W2891688056 cites W2264552698 @default.
- W2891688056 cites W2275623647 @default.
- W2891688056 cites W2288353973 @default.
- W2891688056 cites W2314149200 @default.
- W2891688056 cites W2329824431 @default.
- W2891688056 cites W2336209849 @default.
- W2891688056 cites W2340348123 @default.
- W2891688056 cites W2347038466 @default.
- W2891688056 cites W2347185908 @default.