FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891690089> ?p ?o ?g. }

• W2891690089 endingPage "34" @default.
• W2891690089 startingPage "28" @default.
• W2891690089 abstract "Members of Mas related G-protein coupled receptors (Mrgpr) are known to mediate itch. To date, several compounds have been shown to activate these receptors, including chloroquine, a common antimalarial drug, and peptides of the RF-amide family. However, specific ligands for these receptors are still lacking and there is a need for novel compounds that can be used to modulate the receptors in order to understand the cellular and molecular mechanism in which they mediate itch. Some cone snail venoms were previously shown to induce itch in mice. Here, we show that the venom of Conus textile induces itch through activation of itch-sensing sensory neurons, marked by their sensitivity to chloroquine. Two RF-amide peptides, CNF-Tx1 and CNF-Tx2, were identified in a C. textile venom gland transcriptome. These belong to the conorfamide family of peptides which includes previously described peptides from the venoms of Conus victoriae (CNF-Vc1) and Conus spurius (CNF-Sr1 and CNF-Sr2). We show that CNF-Vc1 and CNF-Sr1 activate MrgprC11 whereas CNF-Vc1 and CNF-Tx2 activate the human MrgprX1 (hMrgprX1). The peptides CNF-Tx1 and CNF-Sr2 do not activate MrgprC11 or hMrgprX1. Intradermal injection of CNF-Vc1 and CNF-Tx2 into the cheek of a transgenic mouse expressing hMrgprX1 instead of endogenous mouse Mrgprs resulted in itch-related scratching thus demonstrating the in vivo activity of these peptides. Using truncated analogues of CNF-Vc1, we identified amino acids at positions 7-14 as important for activity against hMrgprX1. The conopeptides reported here are tools that can be used to advance our understanding of the cellular and molecular mechanism of itch mediated by Mrgprs." @default.
• W2891690089 created "2018-09-27" @default.
• W2891690089 creator A5051488627 @default.
• W2891690089 creator A5061587018 @default.
• W2891690089 creator A5068637713 @default.
• W2891690089 creator A5071375088 @default.
• W2891690089 creator A5072082468 @default.
• W2891690089 creator A5072504942 @default.
• W2891690089 creator A5089494194 @default.
• W2891690089 date "2018-11-01" @default.
• W2891690089 modified "2023-09-26" @default.
• W2891690089 title "Conopeptides promote itch through human itch receptor hMgprX1" @default.
• W2891690089 cites W1482798859 @default.
• W2891690089 cites W1969655931 @default.
• W2891690089 cites W1979949060 @default.
• W2891690089 cites W1983205605 @default.
• W2891690089 cites W1990370343 @default.
• W2891690089 cites W1993960807 @default.
• W2891690089 cites W1995513272 @default.
• W2891690089 cites W2001343650 @default.
• W2891690089 cites W2003703108 @default.
• W2891690089 cites W2004490622 @default.
• W2891690089 cites W2030361493 @default.
• W2891690089 cites W2032529224 @default.
• W2891690089 cites W2047273197 @default.
• W2891690089 cites W2055706749 @default.
• W2891690089 cites W2061190936 @default.
• W2891690089 cites W2072653944 @default.
• W2891690089 cites W2081043810 @default.
• W2891690089 cites W2083566192 @default.
• W2891690089 cites W2087968966 @default.
• W2891690089 cites W2090905251 @default.
• W2891690089 cites W2096191613 @default.
• W2891690089 cites W2100517893 @default.
• W2891690089 cites W2102150987 @default.
• W2891690089 cites W2123046464 @default.
• W2891690089 cites W2128880918 @default.
• W2891690089 cites W2134571618 @default.
• W2891690089 cites W2135906456 @default.
• W2891690089 cites W2144269738 @default.
• W2891690089 cites W2145906584 @default.
• W2891690089 cites W2157848016 @default.
• W2891690089 cites W2157856809 @default.
• W2891690089 cites W2158302928 @default.
• W2891690089 cites W2606631328 @default.
• W2891690089 cites W2614730539 @default.
• W2891690089 cites W2742073754 @default.
• W2891690089 cites W2752151857 @default.
• W2891690089 cites W4239319745 @default.
• W2891690089 doi "https://doi.org/10.1016/j.toxicon.2018.09.002" @default.
• W2891690089 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6299835" @default.
• W2891690089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30243794" @default.
• W2891690089 hasPublicationYear "2018" @default.
• W2891690089 type Work @default.
• W2891690089 sameAs 2891690089 @default.
• W2891690089 citedByCount "13" @default.
• W2891690089 countsByYear W28916900892020 @default.
• W2891690089 countsByYear W28916900892021 @default.
• W2891690089 countsByYear W28916900892022 @default.
• W2891690089 countsByYear W28916900892023 @default.
• W2891690089 crossrefType "journal-article" @default.
• W2891690089 hasAuthorship W2891690089A5051488627 @default.
• W2891690089 hasAuthorship W2891690089A5061587018 @default.
• W2891690089 hasAuthorship W2891690089A5068637713 @default.
• W2891690089 hasAuthorship W2891690089A5071375088 @default.
• W2891690089 hasAuthorship W2891690089A5072082468 @default.
• W2891690089 hasAuthorship W2891690089A5072504942 @default.
• W2891690089 hasAuthorship W2891690089A5089494194 @default.
• W2891690089 hasBestOaLocation W28916900892 @default.
• W2891690089 hasConcept C170493617 @default.
• W2891690089 hasConcept C175234850 @default.
• W2891690089 hasConcept C185592680 @default.
• W2891690089 hasConcept C2779448229 @default.
• W2891690089 hasConcept C55493867 @default.
• W2891690089 hasConcept C86803240 @default.
• W2891690089 hasConcept C95444343 @default.
• W2891690089 hasConcept C98274493 @default.
• W2891690089 hasConceptScore W2891690089C170493617 @default.
• W2891690089 hasConceptScore W2891690089C175234850 @default.
• W2891690089 hasConceptScore W2891690089C185592680 @default.
• W2891690089 hasConceptScore W2891690089C2779448229 @default.
• W2891690089 hasConceptScore W2891690089C55493867 @default.
• W2891690089 hasConceptScore W2891690089C86803240 @default.
• W2891690089 hasConceptScore W2891690089C95444343 @default.
• W2891690089 hasConceptScore W2891690089C98274493 @default.
• W2891690089 hasFunder F4320332161 @default.
• W2891690089 hasLocation W28916900891 @default.
• W2891690089 hasLocation W28916900892 @default.
• W2891690089 hasLocation W28916900893 @default.
• W2891690089 hasLocation W28916900894 @default.
• W2891690089 hasOpenAccess W2891690089 @default.
• W2891690089 hasPrimaryLocation W28916900891 @default.
• W2891690089 hasRelatedWork W1591373153 @default.
• W2891690089 hasRelatedWork W1930766375 @default.
• W2891690089 hasRelatedWork W1988508746 @default.
• W2891690089 hasRelatedWork W2005660925 @default.
• W2891690089 hasRelatedWork W2028390868 @default.
• W2891690089 hasRelatedWork W2073529085 @default.

• next