Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891690157> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2891690157 abstract "Abstract Pinosylvin (trans-3,5-dihydroxystilbene), a naturally occurring analogue of resveratrol (trans-3,5,4′-trihydoxystilbene), exhibited various beneficial pharmacological activities in pre-clinical studies. To further probe its potential medicinal application, a sensitive liquid chromatography–tandem mass spectrometry method (LC–MS/MS) was developed and validated for the quantification of pinosylvin in rat plasma. A simple protein precipitation procedure was used for plasma cleanup before analysis by LC–MS/MS with electrospray ionisation and multiple reaction monitoring in its negative ion mode. This LC–MS/MS method demonstrated good selectivity, accuracy (intra- and inter-day analytical recovery within 100 ± 7.7%), precision (intra- and inter-day coefficient of variation 0.99) over the range of 1–1000 ng/mL. The pharmacokinetic profiles of pinosylvin were subsequently assessed in Sprague–Dawley rats. Following intravenous administration (5 or 10 mg/kg), plasma levels of pinosylvin declined rapidly with a short half-life (t1/2" @default.
- W2891690157 created "2018-09-27" @default.
- W2891690157 creator A5004129071 @default.
- W2891690157 creator A5012065320 @default.
- W2891690157 creator A5024239797 @default.
- W2891690157 creator A5049617665 @default.
- W2891690157 creator A5089519952 @default.
- W2891690157 date "2013-01-01" @default.
- W2891690157 modified "2023-10-07" @default.
- W2891690157 title "Quantification of pinosylvin in rat plasma by liquid chromatography–tandem mass spectrometry: Application to a pre-clinical pharmacokinetic study" @default.
- W2891690157 hasPublicationYear "2013" @default.
- W2891690157 type Work @default.
- W2891690157 sameAs 2891690157 @default.
- W2891690157 citedByCount "0" @default.
- W2891690157 crossrefType "journal-article" @default.
- W2891690157 hasAuthorship W2891690157A5004129071 @default.
- W2891690157 hasAuthorship W2891690157A5012065320 @default.
- W2891690157 hasAuthorship W2891690157A5024239797 @default.
- W2891690157 hasAuthorship W2891690157A5049617665 @default.
- W2891690157 hasAuthorship W2891690157A5089519952 @default.
- W2891690157 hasConcept C112705442 @default.
- W2891690157 hasConcept C162356407 @default.
- W2891690157 hasConcept C185592680 @default.
- W2891690157 hasConcept C194451485 @default.
- W2891690157 hasConcept C31827203 @default.
- W2891690157 hasConcept C40684141 @default.
- W2891690157 hasConcept C43617362 @default.
- W2891690157 hasConcept C64489805 @default.
- W2891690157 hasConcept C71043704 @default.
- W2891690157 hasConcept C71924100 @default.
- W2891690157 hasConcept C74774607 @default.
- W2891690157 hasConcept C98274493 @default.
- W2891690157 hasConceptScore W2891690157C112705442 @default.
- W2891690157 hasConceptScore W2891690157C162356407 @default.
- W2891690157 hasConceptScore W2891690157C185592680 @default.
- W2891690157 hasConceptScore W2891690157C194451485 @default.
- W2891690157 hasConceptScore W2891690157C31827203 @default.
- W2891690157 hasConceptScore W2891690157C40684141 @default.
- W2891690157 hasConceptScore W2891690157C43617362 @default.
- W2891690157 hasConceptScore W2891690157C64489805 @default.
- W2891690157 hasConceptScore W2891690157C71043704 @default.
- W2891690157 hasConceptScore W2891690157C71924100 @default.
- W2891690157 hasConceptScore W2891690157C74774607 @default.
- W2891690157 hasConceptScore W2891690157C98274493 @default.
- W2891690157 hasLocation W28916901571 @default.
- W2891690157 hasOpenAccess W2891690157 @default.
- W2891690157 hasPrimaryLocation W28916901571 @default.
- W2891690157 hasRelatedWork W1245148186 @default.
- W2891690157 hasRelatedWork W1629121594 @default.
- W2891690157 hasRelatedWork W2035502897 @default.
- W2891690157 hasRelatedWork W2087607192 @default.
- W2891690157 hasRelatedWork W2087628927 @default.
- W2891690157 hasRelatedWork W2203508937 @default.
- W2891690157 hasRelatedWork W2374827345 @default.
- W2891690157 hasRelatedWork W2742732685 @default.
- W2891690157 hasRelatedWork W2769320636 @default.
- W2891690157 hasRelatedWork W2771979038 @default.
- W2891690157 hasRelatedWork W2788748104 @default.
- W2891690157 hasRelatedWork W2900612272 @default.
- W2891690157 hasRelatedWork W2906270633 @default.
- W2891690157 hasRelatedWork W2921734589 @default.
- W2891690157 hasRelatedWork W2947016621 @default.
- W2891690157 hasRelatedWork W2972546838 @default.
- W2891690157 hasRelatedWork W3020954155 @default.
- W2891690157 hasRelatedWork W3027741071 @default.
- W2891690157 hasRelatedWork W3110875240 @default.
- W2891690157 hasRelatedWork W3170800012 @default.
- W2891690157 isParatext "false" @default.
- W2891690157 isRetracted "false" @default.
- W2891690157 magId "2891690157" @default.
- W2891690157 workType "article" @default.