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- W2891691975 abstract "Abstract The application of phosphorodiamidate technology to pyrimidine and purine nucleosides with anticancer activity to potentially overcome the resistance mechanisms associated with parent nucleosides is reported. Sixteen symmetrical phosphorodiamidates were prepared from the natural amino acids l ‐alanine and glycine. All the compounds were evaluated for their cytotoxic activity against a wide panel of solid and leukaemic tumour cell lines. In addition, a carboxypeptidase Y assay was performed on a representative phosphorodiamidate in order to reveal the putative bioactivation pathway for the reported phosphorodiamidate‐type prodrugs." @default.
- W2891691975 created "2018-09-27" @default.
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- W2891691975 date "2018-11-06" @default.
- W2891691975 modified "2023-09-27" @default.
- W2891691975 title "Symmetrical Diamidates as a Class of Phosphate Prodrugs to Deliver the 5′‐Monophosphate Forms of Anticancer Nucleoside Analogues" @default.
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- W2891691975 doi "https://doi.org/10.1002/cmdc.201800504" @default.
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