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- W2891696518 abstract "How tumor microenvironmental forces shape plasticity of cancer cell morphology is poorly understood. Here, we conduct automated histology image and spatial statistical analyses in 514 high grade serous ovarian samples to define cancer morphological diversification within the spatial context of the microenvironment. Tumor spatial zones, where cancer cell nuclei diversify in shape, are mapped in each tumor. Integration of this spatially explicit analysis with omics and clinical data reveals a relationship between morphological diversification and the dysregulation of DNA repair, loss of nuclear integrity, and increased disease mortality. Within the Immunoreactive subtype, spatial analysis further reveals significantly lower lymphocytic infiltration within diversified zones compared with other tumor zones, suggesting that even immune-hot tumors contain cells capable of immune escape. Our findings support a model whereby a subpopulation of morphologically plastic cancer cells with dysregulated DNA repair promotes ovarian cancer progression through positive selection by immune evasion." @default.
- W2891696518 created "2018-09-27" @default.
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- W2891696518 date "2018-09-25" @default.
- W2891696518 modified "2023-10-16" @default.
- W2891696518 title "Microenvironmental niche divergence shapes BRCA1-dysregulated ovarian cancer morphological plasticity" @default.
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- W2891696518 doi "https://doi.org/10.1038/s41467-018-06130-3" @default.
- W2891696518 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6156340" @default.
- W2891696518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30254278" @default.
- W2891696518 hasPublicationYear "2018" @default.
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