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- W2891702092 abstract "Cardiovascular (CV) diseases are the most frequent cause of death in patients with end-stage-renal-disease (ESRD). Increased arteries stiffness (AS) was found to be independent risk factor. In generalpopulation AS is determined by age and blood pressure (BP). In patients with chronic renal disease(CKD) it is influenced additionaly with derangements in phosphate and calcium homeostasis. Endemic(Balkan) nephropathy (EN) is a chronic tubulointerstitial nephropathy characterized by normal BP valuesin early stages of CKD and hypertension (HT) appears in advanced CKD stages. Obviously, BP in EN hasless impact on AS than in other CKD. The aim of this study was to analyze whether AS is lower in ENpatients compared to patients with other ESRD undergoing chronic hemodialysis. In this study, 186patients were included (90 EN, 96 non-EN) from three dialysis centers in Croatia and Bosnia andHerzegovina. After 25 months, control measurements were taken on 97 survived patients still treated withchronic hemodialysis. The obtained results confirmed the hypothesis that AS is lower in patients with EN.Prevalence of hypertension was lower in EN patients and they required less antihypertensives. Patientswith EN had significantly lower serum phosphate levels, calcium x phosphate, and parathormone. Allthese factors were predictors of AS, but in three models of linear regression EN was the strongest negativepredictor for AS. In logistic regression the ratio of AS was statistically significantly higher in patientswithout EN. The patients with EN were significantly older when they started their dialysis treatment,which indicates the slower progression of CKD. These patients had significantly lower CV mortality after25 months of follow-up. Endemic nephropathy is an independent predictor of lower AS values. ASdevelops slower due to later onset of HT in predialytic course, lower BP values and milder HT and bettercontrol during dialysis treatment. In addition, they had better control of calcium and phosphates, whichconsequently causes slower progression of kidney disease and lower CV mortality." @default.
- W2891702092 created "2018-09-27" @default.
- W2891702092 creator A5022964279 @default.
- W2891702092 date "2016-05-16" @default.
- W2891702092 modified "2023-09-27" @default.
- W2891702092 title "Krutost velikih arterija u terminalnoj fazi endemske nefropatije [Large-artery stiffness in end-stage Endemic nephropathy]" @default.
- W2891702092 hasPublicationYear "2016" @default.
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