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- W2891704798 endingPage "1011" @default.
- W2891704798 startingPage "996" @default.
- W2891704798 abstract "Background & aim The results of studies about the effect of soy products on serum highly sensitive C-reactive protein (hs-CRP) are inconsistent. The aim of this systematic review and meta-analysis of randomized clinical trials (RCTs) was to investigate the effect of soy products intake on serum hs-CRP concentration. Methods We searched PubMed, EMBASE, Science Direct, ISI Web of Science, Google Scholar and Cochrane Central Register of Controlled Trials up to December 2016 without language restrictions. Random-effect model was used for quantitative data synthesis. Results Thirty-six studies were included in our analyses. A meta-analysis revealed a non-significant reduction in serum hs-CRP concentrations following soy products consumption, −0.19 (mg/L) (95% CI: −0.49 to 0.09; I2 = 95.6%). Subgroup analyses suggested that natural soya products may reduce plasma levels of CRP by −0.18 mg/L (95% CI: −0.28 to −0.08; I2: 11.6) in comparison to other source of isoflavones (soya extracts, supplements). Moreover, the effect was stronger among subjects with baseline hs-CRP concentrations of less than 2.52 mg/L, −0.15 (95% CI: −0.27 to −0.02; I2: 34.6). A meta-regression analysis revealed that dosage of isoflavones seems to be a strong predictor of the effect of soya on serum hs-CRP levels. Conclusion Present review of RCTs published up to December 2016 did not provide strong evidence regarding the beneficial effect of soya products consumption on blood hs-CRP concentrations. However, it appears that natural soya products may reduce plasma levels of hs-CRP in comparison to other source of isoflavones. Large and well-designed studies are recommended to confirm this conclusion. Systematic review registration PROSPERO CRD42018069371." @default.
- W2891704798 created "2018-09-27" @default.
- W2891704798 creator A5003659871 @default.
- W2891704798 creator A5010639009 @default.
- W2891704798 creator A5030187319 @default.
- W2891704798 creator A5040188320 @default.
- W2891704798 date "2019-06-01" @default.
- W2891704798 modified "2023-09-23" @default.
- W2891704798 title "A systematic review and meta-analysis of the effects of soy on serum hs-CRP" @default.
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