Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891708608> ?p ?o ?g. }
- W2891708608 abstract "Abstract Phospholipids are asymmetrically distributed across mammalian plasma membrane with phosphatidylserine (PS) and phosphatidylethanolamine concentrated in the cytoplasmic leaflet of the membrane bilayer. This asymmetric distribution is dependent on a group of P4-ATPases named PS flippases. The proper transport and function of PS flippases require a β-subunit transmembrane protein 30 A (TMEM30A). Disruption of PS flippases led to several human diseases. However, the roles of TMEM30A in the central nervous system remain elusive. To investigate the role of Tmem30a in the cerebellum, we developed a Tmem30a Purkinje cell (PC)-specific knockout (KO) mouse model. The Tmem30a KO mice displayed early-onset ataxia and progressive PC death. Deficiency in Tmem30a led to an increased expression of Glial fibrillary acidic protein and astrogliosis in regions with PC loss. Elevated C/EBP homologous protein and BiP expression levels indicated the presence of endoplasmic reticulum stress in the PCs prior to visible cell loss. Terminal deoxynucleotidyl transferase dUTP nick end labeling ( TUNEL ) analysis suggested that apoptotic cell death occurred in the cerebellum. Our data demonstrate that loss of Tmem30a in PCs results in protein folding and transport defects, a substantial decrease in dendritic spine density, increased astrogliosis and PC death. Taken together, our data demonstrate an essential role of Tmem30a in the cerebellum PCs." @default.
- W2891708608 created "2018-09-27" @default.
- W2891708608 creator A5017304177 @default.
- W2891708608 creator A5032030472 @default.
- W2891708608 creator A5056614628 @default.
- W2891708608 creator A5057411027 @default.
- W2891708608 creator A5058440498 @default.
- W2891708608 creator A5060467128 @default.
- W2891708608 creator A5068508411 @default.
- W2891708608 creator A5075987977 @default.
- W2891708608 creator A5081307254 @default.
- W2891708608 creator A5088513008 @default.
- W2891708608 creator A5089515196 @default.
- W2891708608 date "2018-09-05" @default.
- W2891708608 modified "2023-10-11" @default.
- W2891708608 title "Disruption of Tmem30a results in cerebellar ataxia and degeneration of Purkinje cells" @default.
- W2891708608 cites W1560828533 @default.
- W2891708608 cites W1595798721 @default.
- W2891708608 cites W1968192565 @default.
- W2891708608 cites W1975464681 @default.
- W2891708608 cites W1975689297 @default.
- W2891708608 cites W1999034493 @default.
- W2891708608 cites W2002292732 @default.
- W2891708608 cites W2006831581 @default.
- W2891708608 cites W2007520287 @default.
- W2891708608 cites W2009084021 @default.
- W2891708608 cites W2021284579 @default.
- W2891708608 cites W2021882008 @default.
- W2891708608 cites W2035252238 @default.
- W2891708608 cites W2044345058 @default.
- W2891708608 cites W2046338633 @default.
- W2891708608 cites W2048898883 @default.
- W2891708608 cites W2055873401 @default.
- W2891708608 cites W2056451594 @default.
- W2891708608 cites W2057407467 @default.
- W2891708608 cites W2060119578 @default.
- W2891708608 cites W2060759428 @default.
- W2891708608 cites W2061539000 @default.
- W2891708608 cites W2063863785 @default.
- W2891708608 cites W2066287165 @default.
- W2891708608 cites W2068148220 @default.
- W2891708608 cites W2072179660 @default.
- W2891708608 cites W2074556650 @default.
- W2891708608 cites W2079181228 @default.
- W2891708608 cites W2084606607 @default.
- W2891708608 cites W2089121197 @default.
- W2891708608 cites W2099133435 @default.
- W2891708608 cites W2101690661 @default.
- W2891708608 cites W2104135721 @default.
- W2891708608 cites W2104519044 @default.
- W2891708608 cites W2104772632 @default.
- W2891708608 cites W2113286858 @default.
- W2891708608 cites W2113451302 @default.
- W2891708608 cites W2114916121 @default.
- W2891708608 cites W2129723413 @default.
- W2891708608 cites W2133529176 @default.
- W2891708608 cites W2138752468 @default.
- W2891708608 cites W2145492845 @default.
- W2891708608 cites W2147778357 @default.
- W2891708608 cites W2155955312 @default.
- W2891708608 cites W2165993789 @default.
- W2891708608 cites W2166840071 @default.
- W2891708608 cites W2179142653 @default.
- W2891708608 cites W2184070211 @default.
- W2891708608 cites W2274461262 @default.
- W2891708608 cites W2414848328 @default.
- W2891708608 cites W2749652970 @default.
- W2891708608 cites W2754044861 @default.
- W2891708608 cites W2793388835 @default.
- W2891708608 doi "https://doi.org/10.1038/s41419-018-0938-6" @default.
- W2891708608 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6125289" @default.
- W2891708608 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30185775" @default.
- W2891708608 hasPublicationYear "2018" @default.
- W2891708608 type Work @default.
- W2891708608 sameAs 2891708608 @default.
- W2891708608 citedByCount "21" @default.
- W2891708608 countsByYear W28917086082019 @default.
- W2891708608 countsByYear W28917086082020 @default.
- W2891708608 countsByYear W28917086082021 @default.
- W2891708608 countsByYear W28917086082022 @default.
- W2891708608 countsByYear W28917086082023 @default.
- W2891708608 crossrefType "journal-article" @default.
- W2891708608 hasAuthorship W2891708608A5017304177 @default.
- W2891708608 hasAuthorship W2891708608A5032030472 @default.
- W2891708608 hasAuthorship W2891708608A5056614628 @default.
- W2891708608 hasAuthorship W2891708608A5057411027 @default.
- W2891708608 hasAuthorship W2891708608A5058440498 @default.
- W2891708608 hasAuthorship W2891708608A5060467128 @default.
- W2891708608 hasAuthorship W2891708608A5068508411 @default.
- W2891708608 hasAuthorship W2891708608A5075987977 @default.
- W2891708608 hasAuthorship W2891708608A5081307254 @default.
- W2891708608 hasAuthorship W2891708608A5088513008 @default.
- W2891708608 hasAuthorship W2891708608A5089515196 @default.
- W2891708608 hasBestOaLocation W28917086081 @default.
- W2891708608 hasConcept C158617107 @default.
- W2891708608 hasConcept C169760540 @default.
- W2891708608 hasConcept C185592680 @default.
- W2891708608 hasConcept C190283241 @default.
- W2891708608 hasConcept C196795494 @default.
- W2891708608 hasConcept C203014093 @default.