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- W2891713052 endingPage "33" @default.
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- W2891713052 abstract "Stroke is the second leading cause of death globally and represents a major cause of devastating long-term disability. Despite sustained efforts to develop clinically effective neuroprotective therapies, presently there is no clinically available neuroprotective agent for stroke. As a central mediator of neurodamaging events in stroke, mitochondria are recognised as a critical neuroprotective target, and as such, provide a focus for developing mitochondrial-targeted therapeutics. In recent years, cationic arginine-rich peptides (CARPs) have been identified as a novel class of neuroprotective agent with several demonstrated mechanisms of action, including their ability to target mitochondria and exert positive effects on the organelle. This review provides an overview on neuronal mitochondrial dysfunction in ischaemic stroke pathophysiology and highlights the potential beneficial effects of CARPs on mitochondria in the ischaemic brain following stroke." @default.
- W2891713052 created "2018-09-27" @default.
- W2891713052 creator A5008704373 @default.
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- W2891713052 creator A5039389525 @default.
- W2891713052 creator A5049716242 @default.
- W2891713052 creator A5084014102 @default.
- W2891713052 date "2019-01-01" @default.
- W2891713052 modified "2023-09-26" @default.
- W2891713052 title "Mitochondria and neuroprotection in stroke: Cationic arginine-rich peptides (CARPs) as a novel class of mitochondria-targeted neuroprotective therapeutics" @default.
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