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• W2891713270 endingPage "953" @default.
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• W2891713270 abstract "Hox proteins are master regulatory transcription factors controlling differential morphogenesis in development and evolution. In doing so, each Hox protein displays unique and specific regulatory activities. Recent studies highlight biological processes where Hox proteins are largely interchangeable indicating that nonspecific (generic) action is an as-yet largely unexplored facet of Hox protein activity. Hox generic action is found in multiple tissues, in the embryo and adult, and from Drosophila to vertebrates. The available examples further suggest that generic and specific functions constitute a continuum rather than separable functional entities, in some instances occurring in the same biological context and sharing molecular modalities. Hox transcription factors are essential to promote morphological diversification of the animal body. A substantial number of studies have focused on how Hox proteins reach functional specificity, an issue that arises from the fact that these transcription factors control distinct developmental functions despite sharing similar molecular properties. In this review, we highlight that, besides specific functions, for which these transcription factors are renowned, Hox proteins also often have nonspecific functions. We next discuss some emerging principles of these generic functions and how they relate to specific functions and explore our current grasp of the underlying molecular mechanisms. Hox transcription factors are essential to promote morphological diversification of the animal body. A substantial number of studies have focused on how Hox proteins reach functional specificity, an issue that arises from the fact that these transcription factors control distinct developmental functions despite sharing similar molecular properties. In this review, we highlight that, besides specific functions, for which these transcription factors are renowned, Hox proteins also often have nonspecific functions. We next discuss some emerging principles of these generic functions and how they relate to specific functions and explore our current grasp of the underlying molecular mechanisms. The Generic Facet of Hox Protein Function: (Trends in Genetics , 941–953, 2018)Saurin et al.Trends in GeneticsDecember 7, 2018In BriefIn a previously published version and in the printed version two boxes representing HoxA6 and HoxA7 were missing from Figure 1. These have now been added to a corrected Figure 1 in the online version. Full-Text PDF" @default.
• W2891713270 created "2018-09-27" @default.
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• W2891713270 date "2018-12-01" @default.
• W2891713270 modified "2023-10-12" @default.
• W2891713270 title "The Generic Facet of Hox Protein Function" @default.
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• W2891713270 doi "https://doi.org/10.1016/j.tig.2018.08.006" @default.
• W2891713270 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30241969" @default.
• W2891713270 hasPublicationYear "2018" @default.
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