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• W2891715275 abstract "Immune checkpoint inhibitors (ICIs) have unveiled a new era in the treatment of cancer with unprecedented survival data in multiple tumours [ [1] Thallinger C. Füreder T. Preusser M. Heller G. Müllauer L. Höller C. et al. Review of cancer treatment with immune checkpoint inhibitors : current concepts, expectations, limitations and pitfalls. Wien Klin Wochenschr. 2018; 130: 85-91https://doi.org/10.1007/s00508-017-1285-9 Crossref PubMed Scopus (72) Google Scholar ]. However, there remain a number of patients with only mediocre responses to ICIs, which prompted the investigation of ICI-based combinations to circumvent treatment resistance [ [2] Flynn M.J. Larkin J.M.G. Novel combination strategies for enhancing efficacy of immune checkpoint inhibitors in the treatment of metastatic solid malignancies. Expet Opin Pharmacother. 2017; 18: 1477-1490https://doi.org/10.1080/14656566.2017.1369956 Crossref PubMed Scopus (18) Google Scholar ]. Recent studies have shown that ICI-based combinations caused an increased risk of adverse events namely renal adverse events (rAEs) [ 3 Abdel-Rahman O. Fouad M. A network meta-analysis of the risk of immune-related renal toxicity in cancer patients treated with immune checkpoint inhibitors. Immunotherapy. 2016; 8: 665-674https://doi.org/10.2217/imt-2015-0020 Crossref PubMed Scopus (33) Google Scholar , 4 Wanchoo R. Karam S. Uppal N.N. Barta V.S. Deray G. Devoe C. et al. Adverse renal effects of immune checkpoint inhibitors: a narrative review. Am J Nephrol. 2017; 45: 160-169https://doi.org/10.1159/000455014 Crossref PubMed Scopus (216) Google Scholar ], which seem overall to be rare compared with the more common liver, gastrointestinal, skin and pulmonary toxicities [ [5] De Velasco G. Je Y. Bossé D. Awad M.M. Ott P.A. Moreira R.B. et al. Comprehensive meta-analysis of key immune-related adverse events from CTLA-4 and PD-1/PD-L1 inhibitors in cancer patients. Cancer Immunol Res. 2017; 5: 312-318https://doi.org/10.1158/2326-6066.CIR-16-0237 Crossref PubMed Scopus (297) Google Scholar ]. Despite being relatively rare, the detection and appropriate management of rAEs should be emphasised because the prognosis of cancer patients with kidney dysfunction has been previously shown to be poor [ [6] Kitai Y. Matsubara T. Yanagita M. Onco-nephrology: current concepts and future perspectives. Jpn J Clin Oncol. 2015; 45: 617-628https://doi.org/10.1093/jjco/hyv035 Crossref PubMed Scopus (32) Google Scholar ]. Because the characteristics of rAEs remain largely unknown, we detail a selected pooled analysis of rAEs reported in the melanoma, renal cell carcinoma (RCC) and non–small-cell lung cancer (NSCLC) trials of ICI-based combinations." @default.
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• W2891715275 date "2018-11-01" @default.
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• W2891715275 title "The nephrotoxicity of immune checkpoint inhibitor–based combinations" @default.
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• W2891715275 doi "https://doi.org/10.1016/j.ejca.2018.07.126" @default.
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