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• W2891716460 abstract "Chronic myeloid leukemia (CML) is defined by the presence of Philadelphia chromosome (Ph), resulting from a reciprocal translocation between chromosomes 9 and 22 [t(9;22] that gives rise to a BCR-ABL1 fusion gene. CML occurs in 3 different phases (chronic, accelerated, and blast phase) and is usually diagnosed in the chronic phase. Tyrosine kinase inhibitor (TKI) therapy is a highly effective first-line treatment option for all patients with newly diagnosed chronic phase CML (CP-CML). The selection TKI therapy should be based on the risk score, toxicity profile of TKI, patient's age, ability to tolerate therapy, and the presence of comorbid conditions. This manuscript discusses the recommendations outlined in the NCCN Guidelines for the diagnosis and management of patients with CP-CML." @default.
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• W2891716460 date "2018-09-01" @default.
• W2891716460 modified "2023-10-11" @default.
• W2891716460 title "Chronic Myeloid Leukemia, Version 1.2019, NCCN Clinical Practice Guidelines in Oncology" @default.
• W2891716460 doi "https://doi.org/10.6004/jnccn.2018.0071" @default.
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