Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891719709> ?p ?o ?g. }
- W2891719709 abstract "Alternative splicing is a pervasive mechanism that molds the transcriptome to meet cell and organism needs. However, how this layer of gene expression regulation is coordinated with other aspects of the cell metabolism is still largely undefined. Glucose is the main energy and carbon source of the cell. Not surprisingly, its metabolism is finely tuned to satisfy growth requirements and in response to nutrient availability. A number of studies have begun to unveil the connections between glucose metabolism and splicing programs. Alternative splicing modulates the ratio between M1 and M2 isoforms of pyruvate kinase in this way determining the choice between aerobic glycolysis and complete glucose oxidation in the Krebs cycle. Reciprocally, intermediates in the Krebs cycle may impact splicing programs at different levels by modulating the activity of 2-oxoglutarate-dependent oxidases. In this review we discuss the molecular mechanisms that coordinate alternative splicing programs with glucose metabolism, two aspects with profound implications in human diseases." @default.
- W2891719709 created "2018-09-27" @default.
- W2891719709 creator A5021705710 @default.
- W2891719709 creator A5029445733 @default.
- W2891719709 creator A5084584707 @default.
- W2891719709 date "2018-09-26" @default.
- W2891719709 modified "2023-10-03" @default.
- W2891719709 title "The Krebs Cycle Connection: Reciprocal Influence Between Alternative Splicing Programs and Cell Metabolism" @default.
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