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- W2891726812 abstract "INTRODUCTION:Dyslipidemias are an emerging global health challenge yet, they remain underdiagnosed and under treated. Many newer therapies are being discovered for treating these dyslipidemias. Studies have shown that Biotin a B complex vitamin has favourable effects on the plasma lipid profile of diabetic and non diabetic subjects. This study was conducted to find out the effect of pharmacological dosesof biotin on plasma lipid profile of patients with secondary dyslipidemias.AIM AND OBJECTIVES:The objective of this study was to determine and compare the percentage change from baseline in lipid parameters at weeks 1st, 2nd, 4th and 6th week between the two groups – control group which received Atorvastatin 20 mg per day and study group which received Atorvastatin 20 mg per day with Biotin 5mg/day.METHODOLOGY:60 subjects in the age group of 45-60 yrs with secondary dyslipidemia meeting the inclusion criteria were enrolled after getting a written informed consent. After performing baseline laboratory investigations and lipid profile they were randomized into two groupsThe control group. received Atorvastatin 20 mg alone and the study group received Biotin 5mg along with Atorvastatin 20 mg for 6 weeks. Both the groups were followed up till 12 weeks.RESULTS:As compared with monotherapy, combination therapy resulted in greater reduction in total cholesterol (36%) (p<0.001), greater reduction in LDL cholesterol (42%) (p<0.001), greater reduction in triglycerides (26.73%) (p<0.001) and greater reduction in VLDL (36%) (p=0.839) at 6 weeks. Addition of Biotin also resulted in greater rise in HDL (4.17%), but the difference was not statistically significant. The total cholesterol : HDL ratio became 3.54 in the combination group which was in the desirable level. Adverse events were also less in the combination therapy.CONCLUSION:Combination therapy of Biotin 5mg with Atorvastatin 20 mg is more efficacious than Atorvastatin alone in terms of reduction in Total cholesterol, LDL cholesterol and triglycerides. Biotin is a safe and well tolerated adjuvant hypolipidemic agent in secondary dyslipidemias." @default.
- W2891726812 created "2018-09-27" @default.
- W2891726812 creator A5039048622 @default.
- W2891726812 date "2015-04-01" @default.
- W2891726812 modified "2023-09-26" @default.
- W2891726812 title "Evaluation of the Effect of Biotin in Dyslipidemia" @default.
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