FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891727343> ?p ?o ?g. }

• W2891727343 endingPage "199" @default.
• W2891727343 startingPage "188" @default.
• W2891727343 abstract "With fast development and high pace life in modern society, autoimmune diseases like inflammatory bowel disease had become increasingly common. Bu-Zhong-Yi-Qi-Tang (BZYQT), a famous traditional Chinese medicine prescription (TCMP), has been used for 700 years mainly in Eastern Asia countries for the treatment of gastrointestinal and respiratory disorder, and weakness after serious diseases. These diseases were proved to be closely related to human immune system, among which, mucosal immune system is the largest immune system. So it is necessary to discover the mucosal immune related bioactive components of BZYQT.To evaluate the mucosal immunomodulatory bioactivity of BZYQT and ingredients.Peyer's patches were collected from mice administrated orally with BZYQT, its related Octadecylsilane (ODS) fractions and polysaccharide part. Productions of several cytokines including IL-2, IL-4, IL-5, and IFN-γ from T lymphocytes were tested with enzyme linked immunosorbent assay (ELISA) by Peyer's patch cells ex vivo experiments. Chemical profile including low molecular part and polysaccharide part were investigated. Low molecular part of BZYQT and related ODS fractions were analyzed by ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (UPLC-Q/TOF-MS) based on LC-MS information from self-established compound library. exclusion chromatography, and chemical property has been analyzed.Three-days' administration of BZYQT enhanced productions of IL-4 and IFN-γ in T lymphocytes of Peyer's patches in addition to IL-2. Some hydrophobic low molecular weight fractions (30%, 70% and 100% MeOH ODS fraction), which were fractionated from BZYQT by ODS column chromatography, showed enhancing or suppressive effects on productions of IL-2, IL-4 or IL-5 in T lymphocytes of Peyer's patches after oral administration. Besides, 161 components from hydrophobic low molecular weight fractions of BZYQT were unequivocally identified or tentatively characterized by UPLC-Q/TOF-MS according to retention time behaviors and fragments, and most of them were flavonoids and saponins from Glycyrrhizae Radix, Citri Reticulatae Pericarpium, and Cimicifugae Rhizoma. Polysaccharide part was separated and purified both by anion-exchange and size. BZYQT also contained at least one neutral and three weakly or strongly acidic polysaccharides, and analysis of their chemical properties indicated that a neutral polysaccharide was glucan, and acidic polysaccharides possessed heteroglycan and pectic arabinogalactan features. Murine administration of polysaccharide fractions of BZYQT induced different changes on functions of T lymphocytes in Peyer's patches from hydrophobic low molecular weight fractions. By experiment using intranasally-immunized mice, BZYQT negatively regulated antibody response in lung as combinatorial actions of its low molecular weight ingredients and polysaccharides.BZYQT contains several low and macromolecular weight ingredients, which affect to immune-function of T lymphocytes in Peyer's patches, and the formula expresses its regulative activity on lower respiratory immune system through combinatorial actions of these ingredients on immunocompetent cells in Peyer's patches." @default.
• W2891727343 created "2018-09-27" @default.
• W2891727343 creator A5011590619 @default.
• W2891727343 creator A5036634199 @default.
• W2891727343 creator A5044291823 @default.
• W2891727343 creator A5048896828 @default.
• W2891727343 creator A5062959444 @default.
• W2891727343 creator A5064105976 @default.
• W2891727343 creator A5067861098 @default.
• W2891727343 creator A5069973483 @default.
• W2891727343 creator A5070052227 @default.
• W2891727343 date "2019-01-01" @default.
• W2891727343 modified "2023-10-16" @default.
• W2891727343 title "Mucosal immunomodulatory evaluation and chemical profile elucidation of a classical traditional Chinese formula, Bu-Zhong-Yi-Qi-Tang" @default.
• W2891727343 cites W187964413 @default.
• W2891727343 cites W1968017397 @default.
• W2891727343 cites W1968834637 @default.
• W2891727343 cites W1990366290 @default.
• W2891727343 cites W1991042586 @default.
• W2891727343 cites W1995596552 @default.
• W2891727343 cites W1997681610 @default.
• W2891727343 cites W2000704760 @default.
• W2891727343 cites W2008813014 @default.
• W2891727343 cites W2015973523 @default.
• W2891727343 cites W2034629289 @default.
• W2891727343 cites W2045340028 @default.
• W2891727343 cites W2055699589 @default.
• W2891727343 cites W2072029917 @default.
• W2891727343 cites W2083682903 @default.
• W2891727343 cites W2086089196 @default.
• W2891727343 cites W2098802696 @default.
• W2891727343 cites W2100383726 @default.
• W2891727343 cites W2116743189 @default.
• W2891727343 cites W2144665855 @default.
• W2891727343 cites W2165508443 @default.
• W2891727343 cites W2166756963 @default.
• W2891727343 cites W2292249423 @default.
• W2891727343 cites W2332657012 @default.
• W2891727343 cites W2523489454 @default.
• W2891727343 cites W2562978431 @default.
• W2891727343 cites W2774507445 @default.
• W2891727343 cites W4293247451 @default.
• W2891727343 cites W744321331 @default.
• W2891727343 doi "https://doi.org/10.1016/j.jep.2018.08.003" @default.
• W2891727343 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30195569" @default.
• W2891727343 hasPublicationYear "2019" @default.
• W2891727343 type Work @default.
• W2891727343 sameAs 2891727343 @default.
• W2891727343 citedByCount "15" @default.
• W2891727343 countsByYear W28917273432019 @default.
• W2891727343 countsByYear W28917273432021 @default.
• W2891727343 countsByYear W28917273432022 @default.
• W2891727343 countsByYear W28917273432023 @default.
• W2891727343 crossrefType "journal-article" @default.
• W2891727343 hasAuthorship W2891727343A5011590619 @default.
• W2891727343 hasAuthorship W2891727343A5036634199 @default.
• W2891727343 hasAuthorship W2891727343A5044291823 @default.
• W2891727343 hasAuthorship W2891727343A5048896828 @default.
• W2891727343 hasAuthorship W2891727343A5062959444 @default.
• W2891727343 hasAuthorship W2891727343A5064105976 @default.
• W2891727343 hasAuthorship W2891727343A5067861098 @default.
• W2891727343 hasAuthorship W2891727343A5069973483 @default.
• W2891727343 hasAuthorship W2891727343A5070052227 @default.
• W2891727343 hasConcept C142724271 @default.
• W2891727343 hasConcept C185592680 @default.
• W2891727343 hasConcept C188947578 @default.
• W2891727343 hasConcept C203014093 @default.
• W2891727343 hasConcept C204787440 @default.
• W2891727343 hasConcept C2777056448 @default.
• W2891727343 hasConcept C2778019737 @default.
• W2891727343 hasConcept C556039675 @default.
• W2891727343 hasConcept C71924100 @default.
• W2891727343 hasConcept C8891405 @default.
• W2891727343 hasConcept C98274493 @default.
• W2891727343 hasConceptScore W2891727343C142724271 @default.
• W2891727343 hasConceptScore W2891727343C185592680 @default.
• W2891727343 hasConceptScore W2891727343C188947578 @default.
• W2891727343 hasConceptScore W2891727343C203014093 @default.
• W2891727343 hasConceptScore W2891727343C204787440 @default.
• W2891727343 hasConceptScore W2891727343C2777056448 @default.
• W2891727343 hasConceptScore W2891727343C2778019737 @default.
• W2891727343 hasConceptScore W2891727343C556039675 @default.
• W2891727343 hasConceptScore W2891727343C71924100 @default.
• W2891727343 hasConceptScore W2891727343C8891405 @default.
• W2891727343 hasConceptScore W2891727343C98274493 @default.
• W2891727343 hasFunder F4320324324 @default.
• W2891727343 hasLocation W28917273431 @default.
• W2891727343 hasLocation W28917273432 @default.
• W2891727343 hasOpenAccess W2891727343 @default.
• W2891727343 hasPrimaryLocation W28917273431 @default.
• W2891727343 hasRelatedWork W2056385328 @default.
• W2891727343 hasRelatedWork W2220102944 @default.
• W2891727343 hasRelatedWork W2348691329 @default.
• W2891727343 hasRelatedWork W2378851198 @default.
• W2891727343 hasRelatedWork W2577548098 @default.
• W2891727343 hasRelatedWork W2748952813 @default.
• W2891727343 hasRelatedWork W2899084033 @default.
• W2891727343 hasRelatedWork W2946432268 @default.

• next