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- W2891735660 abstract "Background: Major Depressive Disorder (MDD) is common and disabling, but its neural pathophysiology remains unclear. Functional brain network studies in MDD have largely had limited statistical power and data analysis approaches have varied widely. The REST-meta-MDD Project of resting-state fMRI (R-fMRI) addresses these issues. Methods: The 25 research groups in China composing the REST-meta-MDD Project contributed R-fMRI data of 1,300 patients with MDD and 1,128 normal controls (NCs). The data were preprocessed locally with a standardized protocol prior to aggregated group analyses. We focused on functional connectivity (FC) within the default mode network (DMN), frequently reported to show increased FC in MDD. Outcomes: We found decreased instead of increased DMN FC in MDD compared to NCs. We found FC reduction only in recurrent MDD, not in first-episode drug-naive MDD. Decreased DMN FC was associated with medication usage but not with MDD duration or severity. Exploratory analyses also revealed alterations of local intrinsic activity in MDD. Interpretation: We confirmed the key role of DMN in MDD but found reduced rather than increased FC within the DMN. Future studies should test whether decreased DMN FC mediates treatment response. The REST-meta-MDD model can be generalized to longitudinal MDD studies and to other psychiatric disorders. Funding: National Key R&D Program of China, National Natural Science Foundation of China and Chinese Academy of Sciences." @default.
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- W2891735660 date "2018-07-24" @default.
- W2891735660 modified "2023-10-17" @default.
- W2891735660 title "Twenty-Five Cohorts of Major Depressive Disorder in China: Evidence for Reduced but not Enhanced Default Mode Network Functional Connectivity" @default.
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