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• W2891737239 startingPage "71" @default.
• W2891737239 abstract "Antibody Fc effector functions contribute to HIV control and have been implicated in the partial efficacy seen in the RV144 vaccine trial. Fc-mediated trogocytosis has been previously described for anti-cancer antibodies and results in the removal of membrane fragments from target cells. Here we developed a flow cytometry-based assay which measures the transfer of membrane fragments from a gp120-coated CD4+ lymphocytic cell line (CEM.NKR-CCR5 cells stained with a membrane dye PKH26) to monocytic cells (THP-1 cells stained with CFSE). We showed that this transfer occurred rapidly, within 1 h, and was mediated through engagement of the FcγRIIa/b receptors on the THP-1 cells. HIV-specific IgG as well as gp120 and CD4 could be detected on the surface of THP-1 cells in a process that we demonstrated was distinct from phagocytosis. Furthermore, while the THP-1 effector cells remained intact following the receipt of new membrane proteins, the viability of the target CEM.NKR-CCR5 cells decreased over time. Analysis of HIV-specific plasma revealed that antibodies with trogocytic activity were common in acute and chronic HIV infection but were higher in individuals with broadly neutralizing antibody responses We also examined trogocytosis mediated by broadly neutralizing antibodies (bNAbs) targeting multiple epitopes on the BG505.SOSIP.664 trimer and show that levels of binding correlated with the trogocytosis score. Overall, our data describe a new antiviral Fc effector function mediated by HIV-specific antibodies that could be harnessed for vaccination and cure strategies." @default.
• W2891737239 created "2018-09-27" @default.
• W2891737239 creator A5034459408 @default.
• W2891737239 creator A5038341964 @default.
• W2891737239 creator A5046502364 @default.
• W2891737239 creator A5089017889 @default.
• W2891737239 date "2018-12-01" @default.
• W2891737239 modified "2023-10-15" @default.
• W2891737239 title "Measuring the ability of HIV-specific antibodies to mediate trogocytosis" @default.
• W2891737239 cites W1483917899 @default.
• W2891737239 cites W1505046337 @default.
• W2891737239 cites W1580026313 @default.
• W2891737239 cites W1604450591 @default.
• W2891737239 cites W1610114835 @default.
• W2891737239 cites W1619850380 @default.
• W2891737239 cites W1656961899 @default.
• W2891737239 cites W1658565633 @default.
• W2891737239 cites W1666706706 @default.
• W2891737239 cites W1796142965 @default.
• W2891737239 cites W1887985700 @default.
• W2891737239 cites W1935886040 @default.
• W2891737239 cites W1952288345 @default.
• W2891737239 cites W1966754722 @default.
• W2891737239 cites W1976681938 @default.
• W2891737239 cites W1985136634 @default.
• W2891737239 cites W1986610204 @default.
• W2891737239 cites W1995589036 @default.
• W2891737239 cites W1996299884 @default.
• W2891737239 cites W1999184001 @default.
• W2891737239 cites W1999194653 @default.
• W2891737239 cites W2012521762 @default.
• W2891737239 cites W2012923599 @default.
• W2891737239 cites W2020930943 @default.
• W2891737239 cites W2030129290 @default.
• W2891737239 cites W2041083837 @default.
• W2891737239 cites W2045188517 @default.
• W2891737239 cites W2047198040 @default.
• W2891737239 cites W2047663369 @default.
• W2891737239 cites W2049301826 @default.
• W2891737239 cites W2049456898 @default.
• W2891737239 cites W2051258912 @default.
• W2891737239 cites W2052149946 @default.
• W2891737239 cites W2057706762 @default.
• W2891737239 cites W2058141973 @default.
• W2891737239 cites W2061321162 @default.
• W2891737239 cites W2067336798 @default.
• W2891737239 cites W2081305632 @default.
• W2891737239 cites W2083002978 @default.
• W2891737239 cites W2085988761 @default.
• W2891737239 cites W2094480838 @default.
• W2891737239 cites W2105208620 @default.
• W2891737239 cites W2105350254 @default.
• W2891737239 cites W2106329623 @default.
• W2891737239 cites W2113168129 @default.
• W2891737239 cites W2114273761 @default.
• W2891737239 cites W2116693509 @default.
• W2891737239 cites W2118600609 @default.
• W2891737239 cites W2120755075 @default.
• W2891737239 cites W2122427042 @default.
• W2891737239 cites W2122786380 @default.
• W2891737239 cites W2122909018 @default.
• W2891737239 cites W2126654882 @default.
• W2891737239 cites W2130839386 @default.
• W2891737239 cites W2143421242 @default.
• W2891737239 cites W2143728536 @default.
• W2891737239 cites W2150897358 @default.
• W2891737239 cites W2154468886 @default.
• W2891737239 cites W2164119431 @default.
• W2891737239 cites W2165456522 @default.
• W2891737239 cites W2167867167 @default.
• W2891737239 cites W2169656611 @default.
• W2891737239 cites W2170341917 @default.
• W2891737239 cites W2178827573 @default.
• W2891737239 cites W2229789789 @default.
• W2891737239 cites W2288720547 @default.
• W2891737239 cites W2295265813 @default.
• W2891737239 cites W2332167798 @default.
• W2891737239 cites W2347047438 @default.
• W2891737239 cites W2397170433 @default.
• W2891737239 cites W2552150025 @default.
• W2891737239 cites W2579165473 @default.
• W2891737239 cites W2733120775 @default.
• W2891737239 cites W2764340845 @default.
• W2891737239 cites W2768263828 @default.
• W2891737239 cites W2768973669 @default.
• W2891737239 cites W2775556957 @default.
• W2891737239 cites W2779871467 @default.
• W2891737239 cites W2792654187 @default.
• W2891737239 cites W2798055237 @default.
• W2891737239 cites W320510261 @default.
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• W2891737239 doi "https://doi.org/10.1016/j.jim.2018.09.009" @default.
• W2891737239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30240705" @default.
• W2891737239 hasPublicationYear "2018" @default.
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