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• W2891746936 abstract "Introduction A variety of add-on devices and new-generation endoscopes have the potential to detect lesions ‘hidden’ behind colonic folds. We measured the effect of these new modalities on colonoscopy’s lesions miss rates by a meta-analysis of data from individual studies. Materials and methods We performed literature searches in Medline and Cochrane Library for back-to-back randomized-controlled trials evaluating colonoscope add-on devices and new endoscopes in terms of lesions miss rates. The effect size on study outcomes is shown as relative risk (95% confidence interval). Results We identified nine tandem studies with 1594 patients: seven evaluating add-on devices (one with cap, two with Endocuff, one with Endorings, one with Third-Eye Retroscope, two with G-EYE endoscope) and two evaluating the full-spectrum endoscopy system (FUSE) in comparison with conventional colonoscopy (CC). Overall, adenoma miss rate (AMR) was significantly lower with add-on devices/FUSE [0.33 (0.22–0.50), P <0.00001] compared with CC, the effect being similar among the add-on devices [0.35 (0.22–0.57), P <0.0001] and the FUSE [0.26 (0.15–0.46), P <0.00001] studies, respectively. Advanced AMR and polyp miss rate (PMR) were also significantly lower using add-on devices/FUSE [0.30 (0.21–0.44), P <0.0001 and 0.31 (0.13–0.79), P =0.01, respectively]. Use of add-on devices/FUSE scope was associated with significantly lower AMR and PMR in the proximal colon and it was associated with shortening of the colonoscopy surveillance interval. Conclusion Our meta-analysis provides evidence that AMR, advanced AMR, and PMR are significantly lower using add-on to colonoscope devices and the full-spectrum endoscopy systems compared with CC. Heterogeneity among the included studies and the small number of detected advanced adenomas call for cautious interpretation of the results." @default.
• W2891746936 created "2018-09-27" @default.
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• W2891746936 date "2018-12-01" @default.
• W2891746936 modified "2023-10-14" @default.
• W2891746936 title "Meta-analysis indicates that add-on devices and new endoscopes reduce colonoscopy adenoma miss rate" @default.
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• W2891746936 doi "https://doi.org/10.1097/meg.0000000000001245" @default.
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