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• W2891748259 abstract "A feeding trial was conducted to investigate the effects of differently processed yeast products (hydrolyzed or non-hydrolyzed) derived from Kluyveromyces fragilis on immunological parameters of piglets in an early phase post weaning (d 1–14). A total of 48 male and female piglets (6.17 ± 0.32 kg BW, weaned at d 25) were allocated to three dietary groups (n = 8 replicates with two piglets each) receiving a control diet (CON) or diets with 1% non-hydrolyzed yeast (Diet NHY) or 1% hydrolyzed yeast (Diet HY). The piglets were fed isoenergetic and isonitrogenous diets and had ad-libitum access to feed (mash form) and drinking water. Blood samples were taken at d 1 and d 14 for differential blood count and phenotyping of lymphocytes and at d 1, d 3 and d 14 for analysis of phagocytic activity of leukocytes. Eight animals per treatment were sacrificed 2 weeks after weaning for jejunal and colonal tissue sampling for mRNA extraction and gene expression analysis of cytokines (TNFα, IL-6, IL-10, IL-12) and of tight junction proteins. Different treatments had no effect on piglet growth rate. Fecal scores were improved at d 8 after weaning in the yeast supplemented Groups HY and NHY (P < 0.05). Differential blood count, phenotyping of lymphocytes, and mRNA expression of cytokines and tight junction proteins were not affected by dietary treatment. Significant time-dependent effects on the blood concentrations (G/L) of leucocytes, lymphocytes, monocytes, and on phenotypes of peripheral lymphocytes (%) such as B-cells (P < 0.001), cytotoxic T-cells and monocytes (P < 0.01) have been observed. The difference between lymphocyte counts on d 1 and d 14 was highest in Group HY (P < 0.001). Compared with Group CON, the phagocytic activity of monocytes at d 3 after weaning was higher in Groups HY and NHY (P < 0.05). In conclusion, both yeast products (HY and NHY) had minor effects on adaptive immune parameters, but increased innate immune response such as phagocytosis activity at d 3. Changes in adaptive immune response were more time-dependent than diet-dependent." @default.
• W2891748259 created "2018-09-27" @default.
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• W2891748259 date "2018-11-01" @default.
• W2891748259 modified "2023-10-14" @default.
• W2891748259 title "Effect of time and dietary supplementation with processed yeasts (Kluyveromyces fragilis) on immunological parameters in weaned piglets" @default.
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• W2891748259 doi "https://doi.org/10.1016/j.anifeedsci.2018.09.008" @default.
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