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- W2891752284 abstract "Introduction: Retaining DNA integrity is essential to induced-pluripotent stem cells. p53 regulates a wide range of cellular processes including cell death and cell cycle progression, cell metabolism and DNA damage and repair. p53 is composed of transactivation domain (TAD), proline-rich region, DNA-binding domain, tetramerization domain and extreme carboxyl domain. The role of p53 in DNA damage and repair mechanisms has been studied extensively in various somatic cells. However, the role of p53 TAD, a multifunctional and dynamic domain, on DNA damage repair and retaining DNA integrity in human cardiac fibroblast derived induced-pluripotent stem cells (hiPS) cells has not been studied. Methods: The transactivation domain of p53 was knocked out using CRISPR/Cas9 system. Both, hiPS cells expressing wild type p53 (p53WT) and p53 TAD knockout (p53TADKO) were exposed to low dose of doxorubicin to induce oxidative stress and DNA damage. DNA damage was assessed by comet assay utilizing OxiSelect Comet Assay kit ..." @default.
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- W2891752284 date "2016-11-11" @default.
- W2891752284 modified "2023-10-06" @default.
- W2891752284 title "Abstract 19566: Transactivation Domain of P53 Regulates DNA Integrity in Human Cardiac Fibroblast Derived iPS Cells" @default.
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