FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891752812> ?p ?o ?g. }

• W2891752812 abstract "Background Huntington’s disease (HD) is an autosomal dominantly inherited neurodegenerative disorder, caused by an expansion of a trinucleotide (CAG) repeat in the huntingtin gene. There is no cure and only sparse symptomatic treatment. Structural brain imaging is the most applied and well documented technique to demonstrate longitudinal structural changes in premanifest and manifest HD gene-expansion carriers. Changes in the striatum are registered as far as 15 years before symptom onset with MRI. PET studies have found hypometabolism in the Caudate nucleus, Putamen and the temporal and frontal cortex years before clinical diagnosis along with hypermetabolism in Thalamus prior to symptom onset. Aims By a hybrid brain PET-MRI using FDG, we wished to simultaneously characterize the structural and metabolic brain changes in premanifest HD gene-expansion carriers and address the question whether changes in the metabolism precede the structural changes. Methods We recruited 21 premanifest HD gene-expansion carriers and 17 controls from the Neurogenetics Clinic, Danish Dementia Research Centre, Rigshospitalet, Denmark. We included individuals with CAG repeat ≥39 and a Unified HD Rating scale total motor score ≤5. Results We found a significantly lower (p=0.028) striatal metabolism in the HD gene expansion carrier group compared to gene-negative controls, while there was no significant striatal volume difference. We found a significant correlation between both striatal metabolism and CAP score and striatal volume and CAP score. The higher the CAP score, the lower the metabolism and striatal volume. We also found a significant positive association between striatal metabolism and MRI volume. Conclusions Our results suggest that striatal hypometabolism precedes atrophy; however longitudinal studies on larger cohorts using hybrid FDG-PET/MRI are needed to precisely assess the changes and evolution in time." @default.
• W2891752812 created "2018-09-27" @default.
• W2891752812 creator A5007149982 @default.
• W2891752812 creator A5016536007 @default.
• W2891752812 creator A5017240332 @default.
• W2891752812 creator A5018818892 @default.
• W2891752812 creator A5023685151 @default.
• W2891752812 creator A5054072383 @default.
• W2891752812 creator A5064865113 @default.
• W2891752812 creator A5076236181 @default.
• W2891752812 creator A5080864601 @default.
• W2891752812 date "2018-09-01" @default.
• W2891752812 modified "2023-10-16" @default.
• W2891752812 title "E09 Hybrid brain positron emision tomography – magnetic resonance imaging using flurodeoxyglucose (FDG – PET/MRI) in premanifest huntingtons disease gene-expansion" @default.
• W2891752812 doi "https://doi.org/10.1136/jnnp-2018-ehdn.103" @default.
• W2891752812 hasPublicationYear "2018" @default.
• W2891752812 type Work @default.
• W2891752812 sameAs 2891752812 @default.
• W2891752812 citedByCount "0" @default.
• W2891752812 crossrefType "proceedings-article" @default.
• W2891752812 hasAuthorship W2891752812A5007149982 @default.
• W2891752812 hasAuthorship W2891752812A5016536007 @default.
• W2891752812 hasAuthorship W2891752812A5017240332 @default.
• W2891752812 hasAuthorship W2891752812A5018818892 @default.
• W2891752812 hasAuthorship W2891752812A5023685151 @default.
• W2891752812 hasAuthorship W2891752812A5054072383 @default.
• W2891752812 hasAuthorship W2891752812A5064865113 @default.
• W2891752812 hasAuthorship W2891752812A5076236181 @default.
• W2891752812 hasAuthorship W2891752812A5080864601 @default.
• W2891752812 hasConcept C104317684 @default.
• W2891752812 hasConcept C118552586 @default.
• W2891752812 hasConcept C126322002 @default.
• W2891752812 hasConcept C126838900 @default.
• W2891752812 hasConcept C134018914 @default.
• W2891752812 hasConcept C142724271 @default.
• W2891752812 hasConcept C143409427 @default.
• W2891752812 hasConcept C15744967 @default.
• W2891752812 hasConcept C166252455 @default.
• W2891752812 hasConcept C169760540 @default.
• W2891752812 hasConcept C180754005 @default.
• W2891752812 hasConcept C2775842073 @default.
• W2891752812 hasConcept C2777464067 @default.
• W2891752812 hasConcept C2779134260 @default.
• W2891752812 hasConcept C2779246727 @default.
• W2891752812 hasConcept C2779714222 @default.
• W2891752812 hasConcept C2780062018 @default.
• W2891752812 hasConcept C2780647506 @default.
• W2891752812 hasConcept C2781423529 @default.
• W2891752812 hasConcept C2989005 @default.
• W2891752812 hasConcept C513476851 @default.
• W2891752812 hasConcept C55493867 @default.
• W2891752812 hasConcept C58693492 @default.
• W2891752812 hasConcept C71924100 @default.
• W2891752812 hasConcept C86803240 @default.
• W2891752812 hasConceptScore W2891752812C104317684 @default.
• W2891752812 hasConceptScore W2891752812C118552586 @default.
• W2891752812 hasConceptScore W2891752812C126322002 @default.
• W2891752812 hasConceptScore W2891752812C126838900 @default.
• W2891752812 hasConceptScore W2891752812C134018914 @default.
• W2891752812 hasConceptScore W2891752812C142724271 @default.
• W2891752812 hasConceptScore W2891752812C143409427 @default.
• W2891752812 hasConceptScore W2891752812C15744967 @default.
• W2891752812 hasConceptScore W2891752812C166252455 @default.
• W2891752812 hasConceptScore W2891752812C169760540 @default.
• W2891752812 hasConceptScore W2891752812C180754005 @default.
• W2891752812 hasConceptScore W2891752812C2775842073 @default.
• W2891752812 hasConceptScore W2891752812C2777464067 @default.
• W2891752812 hasConceptScore W2891752812C2779134260 @default.
• W2891752812 hasConceptScore W2891752812C2779246727 @default.
• W2891752812 hasConceptScore W2891752812C2779714222 @default.
• W2891752812 hasConceptScore W2891752812C2780062018 @default.
• W2891752812 hasConceptScore W2891752812C2780647506 @default.
• W2891752812 hasConceptScore W2891752812C2781423529 @default.
• W2891752812 hasConceptScore W2891752812C2989005 @default.
• W2891752812 hasConceptScore W2891752812C513476851 @default.
• W2891752812 hasConceptScore W2891752812C55493867 @default.
• W2891752812 hasConceptScore W2891752812C58693492 @default.
• W2891752812 hasConceptScore W2891752812C71924100 @default.
• W2891752812 hasConceptScore W2891752812C86803240 @default.
• W2891752812 hasLocation W28917528121 @default.
• W2891752812 hasOpenAccess W2891752812 @default.
• W2891752812 hasPrimaryLocation W28917528121 @default.
• W2891752812 hasRelatedWork W1978048848 @default.
• W2891752812 hasRelatedWork W2066704004 @default.
• W2891752812 hasRelatedWork W2072697147 @default.
• W2891752812 hasRelatedWork W2076272048 @default.
• W2891752812 hasRelatedWork W2082103528 @default.
• W2891752812 hasRelatedWork W2089937710 @default.
• W2891752812 hasRelatedWork W2103628198 @default.
• W2891752812 hasRelatedWork W2111423651 @default.
• W2891752812 hasRelatedWork W2158763379 @default.
• W2891752812 hasRelatedWork W2166171037 @default.
• W2891752812 hasRelatedWork W2194853407 @default.
• W2891752812 hasRelatedWork W2415480835 @default.
• W2891752812 hasRelatedWork W2417243807 @default.
• W2891752812 hasRelatedWork W2463691924 @default.
• W2891752812 hasRelatedWork W2826248240 @default.
• W2891752812 hasRelatedWork W2910582043 @default.
• W2891752812 hasRelatedWork W3007473460 @default.
• W2891752812 hasRelatedWork W3166962994 @default.

• next