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• W2891754900 startingPage "583" @default.
• W2891754900 abstract "When DNA is unwound during replication, it becomes overtwisted and forms positive supercoils in front of the translocating DNA polymerase. Unless removed or dissipated, this superhelical tension can impede replication elongation. Topoisomerases, including gyrase and topoisomerase IV in bacteria, are required to relax positive supercoils ahead of DNA polymerase but may not be sufficient for replication. Here, we find that GapR, a chromosome structuring protein in Caulobacter crescentus, is required to complete DNA replication. GapR associates in vivo with positively supercoiled chromosomal DNA, and our biochemical and structural studies demonstrate that GapR forms a dimer-of-dimers that fully encircles overtwisted DNA. Further, we show that GapR stimulates gyrase and topo IV to relax positive supercoils, thereby enabling DNA replication. Analogous chromosome structuring proteins that locate to the overtwisted DNA in front of replication forks may be present in other organisms, similarly helping to recruit and stimulate topoisomerases during DNA replication." @default.
• W2891754900 created "2018-09-27" @default.
• W2891754900 creator A5035590732 @default.
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• W2891754900 date "2018-10-01" @default.
• W2891754900 modified "2023-10-10" @default.
• W2891754900 title "A Bacterial Chromosome Structuring Protein Binds Overtwisted DNA to Stimulate Type II Topoisomerases and Enable DNA Replication" @default.
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• W2891754900 doi "https://doi.org/10.1016/j.cell.2018.08.029" @default.
• W2891754900 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6173638" @default.
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• W2891754900 hasPublicationYear "2018" @default.
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