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• W2891758019 abstract "e23075 Background: Detection of androgen receptor splice variant 7 (AR-V7) in circulating tumor cells (CTCs) has been linked to primary resistance to ABI and enzalutamide (ENZ) (Antonarakis et al. N Engl J Med 2014). We have recently developed a RT-PCR assay for detecting prostate cancer (PCa)-associated transcripts in whole blood. Using this assay, which is not time sensitive and does not require CTC capture and enrichment, we correlated whole blood AR-V7 expression with outcomes on ABI. Methods: 2.5 ml whole blood was collected into PAXgene RNA tubes. RT-PCR was performed for the following genes: AR-V7, FOXA1, GRHL2, HOXB13, KLK2, KLK3 and TMPRSS2:ERG. For each gene, the highest CT value among 20 normal controls was set as the threshold for a positive (+) test. Gene expression was correlated with the following clinical endpoints: PSA50 response rate (RR) (PSA decline ≥ 50% confirmed ≥ 3 weeks later), PSA30 RR, time to PSA (PCWG2 criteria) or clinical progression (change in anti-cancer therapy or decline in ECOG performance status (PS) ≥ 2 levels due to PCa), and overall survival (OS). Results: 37 mCRPC patients commencing ABI were recruited from 2 Canadian academic centres. Median age was 70. 59% received prior docetaxel. All pts were ABI and ENZ naïve. PSA50 RR was 37% and PSA30 RR was 48%. Median progression-free survival (PFS) was 3.8 months (mos) and median OS was 21.0 mos. 11% (4/37) of pts were AR-V7+. AR-V7+ pts had higher ALP (P= 0.04; Χ2), higher LDH (P= 0.07) and were more likely to be ECOG PS ≥ 2 (P= 0.052). AR-V7+ disease was associated with lower PSA50 RR (0% vs. 42%, P= 0.10; Χ2) and PSA30 RR (0% vs. 52%, P= 0.051) plus shorter median PFS (0.7 mos vs. 4.0 mos, P< 0.001; log-rank) and median OS (5.5 mos vs. 22.1 mos, P< 0.001). Other factors associated with worse OS were high ALP (P= 0.02), liver metastases (P= 0.03), ≤ 36 mos on primary hormone therapy (P= 0.04), HOXB13+ (P= 0.03) and KLK2+ (P< 0.001). Conclusions: AR-V7 expression in whole blood was associated with very poor outcomes on ABI. Our data serve to reinforce the potential utility of AR-V7 as a prognostic and predictive biomarker for mCRPC. Validation of these findings in larger datasets is ongoing." @default.
• W2891758019 created "2018-09-27" @default.
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• W2891758019 date "2016-05-20" @default.
• W2891758019 modified "2023-10-02" @default.
• W2891758019 title "Correlation of AR-V7 expression in whole blood with efficacy of abiraterone acetate (ABI) in metastatic castration-resistant prostate cancer (mCRPC) patients (pts)." @default.
• W2891758019 doi "https://doi.org/10.1200/jco.2016.34.15_suppl.e23075" @default.
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