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- W2891763044 abstract "Abstract We examined interactions between Hsp83 and hsrω lncRNAs in hsrω 66 Hsp90GFP homozygotes, which almost completely lack hsrω lncRNAs but over-express Hsp83. All +/+; hsrω 66 Hsp90GFP progeny died before third instar. Rare Sp/CyO; hsrω 66 Hsp90GFP reached third instar stage but phenocopied l(2)gl mutants, dying after prolonged larval life, becoming progressively bulbous and transparent with enlarged brain. Additionally, ventral ganglia were elongated. However, hsrω 66 Hsp90GFP / TM6B heterozygotes, carrying +/+ or Sp/CyO second chromosomes, developed normally. Total RNA sequencing ( +/+, +/+ ; hsrω 66 /hsrω 66 , Sp/CyO; hsrω 66 /hsrω 66 , +/+; Hsp90GFP/Hsp90GFP , and Sp/CyO; hsrω 66 Hsp90GFP/hsrω 66 Hsp90GFP late third instar larvae) revealed similar effects on many genes in hsrω 66 and Hsp90GFP homozygotes. Besides additive effect on many of them, numerous additional genes were affected in Sp/CyO; hsrω 66 Hsp90GFP larvae, with l(2)gl and several genes regulating CNS being highly down-regulated in surviving Sp/CyO; hsrω 66 Hsp90GFP larvae, but not in hsrω 66 or Hsp90GFP single mutants. Hsp83 binds at these gene promoters. Several omega speckle associated hnRNPs too may bind with these genes and transcripts. Hsp83-hnRNP interactions are also known. Thus, elevated Hsp83 in altered hnRNP distribution and dynamics, following absence of hsr ω lncRNAs and omega speckles, background can severely perturb regulatory circuits with unexpected consequences, including down-regulation of tumor suppressor gene like l(2)gl ." @default.
- W2891763044 created "2018-09-27" @default.
- W2891763044 creator A5028828610 @default.
- W2891763044 creator A5050996878 @default.
- W2891763044 creator A5053732204 @default.
- W2891763044 creator A5089464658 @default.
- W2891763044 date "2018-09-18" @default.
- W2891763044 modified "2023-09-27" @default.
- W2891763044 title "Over-expression of Hsp83 in grossly depleted hsrω lncRNA background causes synthetic lethality and l(2)gl phenocopy in Drosophila" @default.
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