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- W2891764507 abstract "Telomeres and telomerase have become attractive targets for the development of anticancer therapeutics due to their involvement in cancer cell immortality. Currently, several therapeutics have been developed that directly target telomerase and telomeres, such as telomerase inhibitors and G-quadruplex stabilizing ligands. Telomere-specific oligonucleotides that reduce telomerase activity and disrupt telomere architecture are also in development as novel anticancer therapeutics. Specifically, GRN163L and T-oligos have demonstrated promising anticancer activity in multiple cancers types via induction of potent DNA damage responses. Currently, several miRNAs have been implicated in the regulation of telomerase activity and may prove to be valuable targets in the development of novel therapies by reducing expression of telomerase subunits. Targeting miRNAs that are known to increase expression of telomerase subunits may be another strategy to reduce carcinogenesis. This review aims to provide a comprehensive understanding of current oligonucleotide-based anticancer therapies that target telomeres and telomerase. These studies may help design novel therapeutic approaches to overcome the challenges of oligonucleotide therapy in a clinical setting." @default.
- W2891764507 created "2018-09-27" @default.
- W2891764507 creator A5006197733 @default.
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- W2891764507 creator A5082922376 @default.
- W2891764507 date "2018-09-05" @default.
- W2891764507 modified "2023-10-08" @default.
- W2891764507 title "Oligonucleotides Targeting Telomeres and Telomerase in Cancer" @default.
- W2891764507 cites W1483708050 @default.
- W2891764507 cites W1500005278 @default.
- W2891764507 cites W1540774389 @default.
- W2891764507 cites W1564838069 @default.
- W2891764507 cites W1648301895 @default.
- W2891764507 cites W1969863269 @default.
- W2891764507 cites W1970657463 @default.
- W2891764507 cites W1975397484 @default.
- W2891764507 cites W1979867463 @default.
- W2891764507 cites W1980320445 @default.
- W2891764507 cites W1981298996 @default.
- W2891764507 cites W198268697 @default.
- W2891764507 cites W1991098068 @default.
- W2891764507 cites W1993013702 @default.
- W2891764507 cites W2001933408 @default.
- W2891764507 cites W2003119703 @default.
- W2891764507 cites W2006606296 @default.
- W2891764507 cites W2009357228 @default.
- W2891764507 cites W2010731545 @default.
- W2891764507 cites W2011863374 @default.
- W2891764507 cites W2012398957 @default.
- W2891764507 cites W2015729243 @default.
- W2891764507 cites W2016199934 @default.
- W2891764507 cites W2017933374 @default.
- W2891764507 cites W2023833929 @default.
- W2891764507 cites W2026968102 @default.
- W2891764507 cites W2028296058 @default.
- W2891764507 cites W2028520651 @default.
- W2891764507 cites W2029399298 @default.
- W2891764507 cites W2033081825 @default.
- W2891764507 cites W2044126891 @default.
- W2891764507 cites W2056289454 @default.
- W2891764507 cites W2056427774 @default.
- W2891764507 cites W2057342950 @default.
- W2891764507 cites W2067685971 @default.
- W2891764507 cites W2072744580 @default.
- W2891764507 cites W2076361525 @default.
- W2891764507 cites W2076382848 @default.
- W2891764507 cites W2079538965 @default.
- W2891764507 cites W2080683596 @default.
- W2891764507 cites W2087513367 @default.
- W2891764507 cites W2097254970 @default.
- W2891764507 cites W2097342690 @default.
- W2891764507 cites W2100215079 @default.
- W2891764507 cites W2103899181 @default.
- W2891764507 cites W2104533892 @default.
- W2891764507 cites W2106625506 @default.
- W2891764507 cites W2107406849 @default.
- W2891764507 cites W2120086108 @default.
- W2891764507 cites W2122080063 @default.
- W2891764507 cites W2125343208 @default.
- W2891764507 cites W2125351886 @default.
- W2891764507 cites W2130211816 @default.
- W2891764507 cites W2132094180 @default.
- W2891764507 cites W2136345741 @default.
- W2891764507 cites W2143127631 @default.
- W2891764507 cites W2145320380 @default.
- W2891764507 cites W2146200359 @default.
- W2891764507 cites W2147997440 @default.
- W2891764507 cites W2148929244 @default.
- W2891764507 cites W2151468358 @default.
- W2891764507 cites W2154116432 @default.
- W2891764507 cites W2161277166 @default.
- W2891764507 cites W2163086395 @default.
- W2891764507 cites W2194006281 @default.
- W2891764507 cites W2265434753 @default.
- W2891764507 cites W2325637194 @default.
- W2891764507 cites W2339718724 @default.
- W2891764507 cites W2375799313 @default.
- W2891764507 cites W2464740767 @default.
- W2891764507 cites W2465907273 @default.
- W2891764507 cites W2490200714 @default.
- W2891764507 cites W2517426872 @default.
- W2891764507 cites W2567455584 @default.
- W2891764507 cites W2571691893 @default.
- W2891764507 cites W2577431949 @default.
- W2891764507 cites W2590353570 @default.
- W2891764507 cites W2595940044 @default.
- W2891764507 cites W2604337946 @default.
- W2891764507 cites W26284591 @default.
- W2891764507 cites W2735261399 @default.
- W2891764507 cites W2737016648 @default.
- W2891764507 cites W2767547341 @default.
- W2891764507 cites W2786455820 @default.