Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891767248> ?p ?o ?g. }
- W2891767248 endingPage "5046" @default.
- W2891767248 startingPage "5036" @default.
- W2891767248 abstract "Abstract Neuropilins ( NRP s) have been described as receptors for class 3 semaphorins and coreceptors for a plethora of ligands, such as members of the vascular endothelial growth factor ( VEGF ) family of angiogenic cytokines and transforming growth factor ( TGF ). Initial studies using genetic models have indicated that neuropilin‐1 ( NRP ‐1) is essential for axonal guidance during neuronal and cardiovascular development, regulated via semaphorins and VEGF , respectively, whereas the other homolog of neuropilin, NRP ‐2, has been shown to play a more specific role in neuronal patterning and lymphangiogenesis. Pancreatic ductal adenocarcinoma ( PDAC ) remains a significant cause of cancer mortality with the lowest five‐year survival rate compared to other types of cancer. Recent findings have indicated that NRP s are abundantly expressed in pancreatic cancer cell lines and pancreatic tumor tissues, where they mediate several essential cancer‐initiating and cancer‐promoting functional responses through their unique ability to bind multiple ligands. Specifically, NRP s have been implicated in numerous biological processes such as cancer cell proliferation, survival, invasion, and tumor growth. More recently, several other protumorigenic roles mediated by NRP s have emerged, advocating NRP s as ideal therapeutic targets against PDAC ." @default.
- W2891767248 created "2018-09-27" @default.
- W2891767248 creator A5004575297 @default.
- W2891767248 creator A5011487319 @default.
- W2891767248 creator A5026371597 @default.
- W2891767248 creator A5032149753 @default.
- W2891767248 creator A5078630865 @default.
- W2891767248 creator A5090217181 @default.
- W2891767248 date "2018-09-14" @default.
- W2891767248 modified "2023-10-14" @default.
- W2891767248 title "Jack of many trades: Multifaceted role of neuropilins in pancreatic cancer" @default.
- W2891767248 cites W1732736480 @default.
- W2891767248 cites W1848910860 @default.
- W2891767248 cites W1848922996 @default.
- W2891767248 cites W1921756464 @default.
- W2891767248 cites W196210671 @default.
- W2891767248 cites W1972502482 @default.
- W2891767248 cites W1973515006 @default.
- W2891767248 cites W1973568716 @default.
- W2891767248 cites W1973955786 @default.
- W2891767248 cites W1974016804 @default.
- W2891767248 cites W1977379410 @default.
- W2891767248 cites W1977748809 @default.
- W2891767248 cites W1989658253 @default.
- W2891767248 cites W1990983421 @default.
- W2891767248 cites W1991827918 @default.
- W2891767248 cites W1995168398 @default.
- W2891767248 cites W1997307365 @default.
- W2891767248 cites W2001439261 @default.
- W2891767248 cites W2004541252 @default.
- W2891767248 cites W2005467912 @default.
- W2891767248 cites W2008161734 @default.
- W2891767248 cites W2010092400 @default.
- W2891767248 cites W2012485042 @default.
- W2891767248 cites W2012922302 @default.
- W2891767248 cites W2014356856 @default.
- W2891767248 cites W2019662547 @default.
- W2891767248 cites W2021376182 @default.
- W2891767248 cites W2022082057 @default.
- W2891767248 cites W2022728491 @default.
- W2891767248 cites W2023332571 @default.
- W2891767248 cites W2024233733 @default.
- W2891767248 cites W2024502310 @default.
- W2891767248 cites W2028037543 @default.
- W2891767248 cites W2029146376 @default.
- W2891767248 cites W2034391789 @default.
- W2891767248 cites W2040562146 @default.
- W2891767248 cites W2042349690 @default.
- W2891767248 cites W2042855108 @default.
- W2891767248 cites W2044494898 @default.
- W2891767248 cites W2049290799 @default.
- W2891767248 cites W2052705131 @default.
- W2891767248 cites W2059405490 @default.
- W2891767248 cites W2062809449 @default.
- W2891767248 cites W2064797051 @default.
- W2891767248 cites W2065850348 @default.
- W2891767248 cites W2067509468 @default.
- W2891767248 cites W2067817921 @default.
- W2891767248 cites W2070985372 @default.
- W2891767248 cites W2072583908 @default.
- W2891767248 cites W2075078693 @default.
- W2891767248 cites W2075465677 @default.
- W2891767248 cites W2076350188 @default.
- W2891767248 cites W2077569461 @default.
- W2891767248 cites W2082138591 @default.
- W2891767248 cites W2083629752 @default.
- W2891767248 cites W2084228496 @default.
- W2891767248 cites W2088252322 @default.
- W2891767248 cites W2088667001 @default.
- W2891767248 cites W2099135679 @default.
- W2891767248 cites W2100314344 @default.
- W2891767248 cites W2101739661 @default.
- W2891767248 cites W2102322990 @default.
- W2891767248 cites W2103328690 @default.
- W2891767248 cites W2107441200 @default.
- W2891767248 cites W2112633723 @default.
- W2891767248 cites W2117692326 @default.
- W2891767248 cites W2119690971 @default.
- W2891767248 cites W2123647020 @default.
- W2891767248 cites W2125227867 @default.
- W2891767248 cites W2130464657 @default.
- W2891767248 cites W2131070390 @default.
- W2891767248 cites W2134051610 @default.
- W2891767248 cites W2144025124 @default.
- W2891767248 cites W2151005088 @default.
- W2891767248 cites W2157923000 @default.
- W2891767248 cites W2158455898 @default.
- W2891767248 cites W2161918376 @default.
- W2891767248 cites W2163326536 @default.
- W2891767248 cites W2165424593 @default.
- W2891767248 cites W2171179595 @default.
- W2891767248 cites W2177732748 @default.
- W2891767248 cites W2262610975 @default.
- W2891767248 cites W2269017219 @default.
- W2891767248 cites W2301831168 @default.
- W2891767248 cites W2346221794 @default.
- W2891767248 cites W2509249166 @default.
- W2891767248 cites W2541304206 @default.