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- W2891777339 endingPage "168" @default.
- W2891777339 startingPage "155" @default.
- W2891777339 abstract "Mitochondrial dysfunction characterized by impaired bioenergetics, oxidative stress and aldehydic load is a hallmark of heart failure. Recently, different research groups have provided evidence that selective activation of mitochondrial detoxifying systems that counteract excessive accumulation of ROS, RNS and reactive aldehydes is sufficient to stop cardiac degeneration upon chronic stress, such as heart failure. Therefore, pharmacological and non-pharmacological approaches targeting mitochondria detoxification may play a critical role in the prevention or treatment of heart failure. In this review we discuss the most recent findings on the central role of mitochondrial dysfunction, oxidative stress and aldehydic load in heart failure, highlighting the most recent preclinical and clinical studies using mitochondria-targeted molecules and exercise training as effective tools against heart failure." @default.
- W2891777339 created "2018-09-27" @default.
- W2891777339 creator A5021248493 @default.
- W2891777339 creator A5022534990 @default.
- W2891777339 creator A5039639608 @default.
- W2891777339 creator A5084030651 @default.
- W2891777339 creator A5091632362 @default.
- W2891777339 date "2018-12-01" @default.
- W2891777339 modified "2023-10-14" @default.
- W2891777339 title "Targeting mitochondrial dysfunction and oxidative stress in heart failure: Challenges and opportunities" @default.
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