Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891780076> ?p ?o ?g. }
- W2891780076 endingPage "87" @default.
- W2891780076 startingPage "65" @default.
- W2891780076 abstract "Hippo signaling is an evolutionarily conserved network that has a central role in regulating cell proliferation and cell fate to control organ growth and regeneration. It promotes activation of the LATS kinases, which control gene expression by inhibiting the activity of the transcriptional coactivator proteins YAP and TAZ in mammals and Yorkie in Drosophila. Diverse upstream inputs, including both biochemical cues and biomechanical cues, regulate Hippo signaling and enable it to have a key role as a sensor of cells’ physical environment and an integrator of growth control signals. Several components of this pathway localize to cell–cell junctions and contribute to regulation of Hippo signaling by cell polarity, cell contacts, and the cytoskeleton. Downregulation of Hippo signaling promotes uncontrolled cell proliferation, impairs differentiation, and is associated with cancer. We review the current understanding of Hippo signaling and highlight progress in the elucidation of its regulatory mechanisms and biological functions." @default.
- W2891780076 created "2018-09-27" @default.
- W2891780076 creator A5004101565 @default.
- W2891780076 creator A5071660392 @default.
- W2891780076 date "2018-11-23" @default.
- W2891780076 modified "2023-10-16" @default.
- W2891780076 title "The Hippo Signaling Network and Its Biological Functions" @default.
- W2891780076 cites W1539804860 @default.
- W2891780076 cites W1578498192 @default.
- W2891780076 cites W1782202106 @default.
- W2891780076 cites W1790041644 @default.
- W2891780076 cites W1847717811 @default.
- W2891780076 cites W1866104439 @default.
- W2891780076 cites W1868480553 @default.
- W2891780076 cites W1870821474 @default.
- W2891780076 cites W1874667452 @default.
- W2891780076 cites W1907685758 @default.
- W2891780076 cites W1941703300 @default.
- W2891780076 cites W1944684136 @default.
- W2891780076 cites W1946514197 @default.
- W2891780076 cites W1963272969 @default.
- W2891780076 cites W1963587413 @default.
- W2891780076 cites W1964952370 @default.
- W2891780076 cites W1966228205 @default.
- W2891780076 cites W1968233108 @default.
- W2891780076 cites W1969104713 @default.
- W2891780076 cites W1969837969 @default.
- W2891780076 cites W1972095962 @default.
- W2891780076 cites W1972464781 @default.
- W2891780076 cites W1975489922 @default.
- W2891780076 cites W1976823719 @default.
- W2891780076 cites W1977291335 @default.
- W2891780076 cites W1978746441 @default.
- W2891780076 cites W1980472339 @default.
- W2891780076 cites W1981831836 @default.
- W2891780076 cites W1982498121 @default.
- W2891780076 cites W1984488853 @default.
- W2891780076 cites W1987648149 @default.
- W2891780076 cites W1988025240 @default.
- W2891780076 cites W1992845452 @default.
- W2891780076 cites W1993926535 @default.
- W2891780076 cites W1999661963 @default.
- W2891780076 cites W2002116477 @default.
- W2891780076 cites W2004102023 @default.
- W2891780076 cites W2005482521 @default.
- W2891780076 cites W2006778392 @default.
- W2891780076 cites W2007886911 @default.
- W2891780076 cites W2016672123 @default.
- W2891780076 cites W2018925318 @default.
- W2891780076 cites W2019621646 @default.
- W2891780076 cites W2020511240 @default.
- W2891780076 cites W2021617179 @default.
- W2891780076 cites W2022960511 @default.
- W2891780076 cites W2023066688 @default.
- W2891780076 cites W2023267153 @default.
- W2891780076 cites W2024424959 @default.
- W2891780076 cites W2031354391 @default.
- W2891780076 cites W2033482280 @default.
- W2891780076 cites W2034071612 @default.
- W2891780076 cites W2047862875 @default.
- W2891780076 cites W2056102163 @default.
- W2891780076 cites W2056182849 @default.
- W2891780076 cites W2058112316 @default.
- W2891780076 cites W2060020667 @default.
- W2891780076 cites W2061058076 @default.
- W2891780076 cites W2066505201 @default.
- W2891780076 cites W2071765960 @default.
- W2891780076 cites W2072304718 @default.
- W2891780076 cites W2075230979 @default.
- W2891780076 cites W2078273305 @default.
- W2891780076 cites W2078377283 @default.
- W2891780076 cites W2079015343 @default.
- W2891780076 cites W2079259838 @default.
- W2891780076 cites W2085197940 @default.
- W2891780076 cites W2086042935 @default.
- W2891780076 cites W2086332492 @default.
- W2891780076 cites W2087766778 @default.
- W2891780076 cites W2088593944 @default.
- W2891780076 cites W2090342940 @default.
- W2891780076 cites W2090698584 @default.
- W2891780076 cites W2091427349 @default.
- W2891780076 cites W2092128105 @default.
- W2891780076 cites W2092471274 @default.
- W2891780076 cites W2094562654 @default.
- W2891780076 cites W2095601153 @default.
- W2891780076 cites W2098692163 @default.
- W2891780076 cites W2099709490 @default.
- W2891780076 cites W2100641053 @default.
- W2891780076 cites W2104914327 @default.
- W2891780076 cites W2108260772 @default.
- W2891780076 cites W2109838283 @default.
- W2891780076 cites W2111900780 @default.
- W2891780076 cites W2112093227 @default.
- W2891780076 cites W2112933956 @default.
- W2891780076 cites W2121072573 @default.
- W2891780076 cites W2121761542 @default.
- W2891780076 cites W2129466238 @default.
- W2891780076 cites W2129480424 @default.